Schizophrenia- A Story Meant to be Painted


This is a story about my Schizophrenia meant to be painted. The years after college   my father passed away on Jan. 2, 2007, due to natural causes and then my sister died the very next day in a car accident on her way to the funeral. I cannot express the pain and anguish that came over me.I suppose all people who are affected by mental illness have that moment when “it” happens—the moment when their condition makes itself known. My moment happened when I was an undergraduate in college. It was in the form of voices, hallucinations and paranoid thoughts that one of my professors was trying to kill me.

Continue reading “Schizophrenia- A Story Meant to be Painted”

Medication Helps Some With Mild Depression

Medication Helps Some With Mild Depression

  People with mild depression may benefit from antidepressants, suggests a new meta-analysis.

Some earlier reports had suggested that antidepressants generally only improve mood in people with severe depression. But that might be because those studies weren’t precise enough to pick up on smaller changes in symptoms that can still make a difference for people with milder forms of the disease, researchers on the new study said. Continue reading “Medication Helps Some With Mild Depression”


The State of Pharmacogenetics Customizing Treatments

By Anil K. Malhotra, MD | April 9, 2010
Dr Malhotra is the director of psychiatry research at the Zucker Hillside Hospital in Glen Oaks, NY, and professor of psychiatry at the Albert Einstein College of Medicine in the Bronx, NY. He is a consultant for PGX Health Inc.

There are limited data on clinical and biological predictors of antipsychotic drug response. The ability to identify those patients who will respond well to psychotropic drug treatment or who will be at a higher risk for adverse effects could help clinicians avoid lengthy ineffective drug trials and limit patients’ exposure to those effects. Moreover, better predictability of treatment response early in the course of a patient’s illness can result in enhanced medication adherence, a significant predictor of relapse prevention.1 Continue reading “NEUROPSYCHOPHARMACOLOGY”

The Effectiveness Of SSRI Antidepressants Reduced By Anti-Inflammatory Drugs

The Effectiveness Of SSRI Antidepressants Reduced By Anti-Inflammatory Drugs

Scientists at the Fisher Center for Alzheimer’s Disease Research at The Rockefeller University, led by Paul Greengard, Ph.D., and Jennifer Warner-Schmidt, Ph.D., have shown that anti-inflammatory drugs, which include ibuprofen, aspirin and naproxen, reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors, or SSRIs, taken for depression and obsessive-compulsive disorder and anxiety disorders. This surprising discovery, published online this week in the Proceedings of the National Academy of Sciences, may explain why so many depressed patients taking SSRIs do not respond to antidepressant treatment and suggests that this lack of effectiveness may be preventable. The study may be especially significant in the case of Alzheimer’s disease. Such patients commonly suffer from depression and unless this can be treated successfully, the course of the illness is likely to be more severe. Depression in the elderly is also a risk factor for developing Alzheimer’s Disease and researchers have suggested that treating depression in the elderly might reduce the risk of developing the disease. Continue reading “The Effectiveness Of SSRI Antidepressants Reduced By Anti-Inflammatory Drugs”

Fat Pharms: Antidepressants and Weight Gain

Up to 25% of people who take antidepressants gain weight. Is there anything you can do about it?

Seeking help for depression — and following through with antidepressant medication — is a courageous and important first step on the road to recovery. But too often, those who take that step find themselves faced with another troubling problem: weight gain.

Experts say that for up to 25% of people, most antidepressant medications — including the popular SSRI (selective serotonin reuptake inhibitor) drugs like Prozac, Lexapro, Paxil, and Zoloft — can cause a weight gain of 10 pounds or more.

“This is a phenomenon that I first noticed years ago when Prozac first came on the market. It didn’t initially show up in the clinical trials because most of them were eight to 12 weeks in length, and the weight gain generally occurs with longer use. But it’s definitely one of the side effects of this and other antidepressant medications,” says Norman Sussman, MD, a psychiatrist and associate dean for postgraduate medical programs at the NYU School of Medicine.
Continue reading “Fat Pharms: Antidepressants and Weight Gain”

Are Antipsychotics Overprescribed?

Editor’s note: Antipsychotics are now the top-selling class of medications in the United States, with prescription sales of $14.6 billion in 2009.[1] Many clinicians worry these agents are being overprescribed and used inappropriately. Medscape recently hosted an email discussion between Dr. Nassir Ghaemi, a psychiatrist, and Dr. Larry Culpepper, a primary care physician with expertise in psychiatry, exploring the question of whether antipsychotics are being used appropriately by prescribing clinicians.

Are Antipsychotics Overprescribed?

Nassir Ghaemi, MD, MPH: I think antipsychotics are overprescribed. Let’s first think about the most legitimate uses, and then we can identify how and why they’re overprescribed. These agents are most legitimately used, obviously, for schizophrenia in both the short term and long term.[2] They are also legitimately used in the short term (meaning a few months) for acute mania.[3] That’s about it, in my view.

Continue reading “Are Antipsychotics Overprescribed?”