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SEROTONIN – THE KEY TO THE PSYCHEDELIC EXPERIENCE:


The brain chemical these drugs increase, serotonin, is the same brain chemical that LSD, PCP and other psychedelic drugs mimic in order to produce their hallucinogenic effects “. . . psychedelic agents mimic the effects of serotonin.” And remember that psychedelic agents are “a class of compounds with no demonstrated therapeutic use, a history of extensive abuse, and the ability to provoke psychosis. Yet many brain researchers value the psychedelic agents above any of the other psychoactive drugs” because “the research into psychedelic drugs has already enriched our understanding of how the brain regulates behavior.” (Dr. Solomon Snyder, DRUGS AND THE BRAIN) Just how much will these brain researchers learn from our experience with these drugs designed to specifically increase serotonin, the same brain chemical the psychedelic agents mimic to produce their effects?

We know that these drugs interfere with serotonin metabolism (demonstrated by levels of the serotonin metabolite 5HIAA). It is not serotonin that is low in these disorders, it is this by product 5HIAA, which indicates the level of serotonin metabolism, that is low in depression, suicide, etc. Yet as serotonin (5HT) goes up serotonin metabolism (5HIAA) generally comes down. We already have studies demonstrating at what percentage each of these drugs increase 5HT and decrease 5HIAA. Now learn the results first of elevated levels of serotonin (5HT) and secondly the results of decreased levels of serotonin metabolism (5HIAA):

Elevated 5HT (serotonin) levels:
#1 schizophrenia, psychosis, mania, etc.
#2 mood disorders (depression, anxiety, etc.)
#3 organic brain disease – especially mental retardation at a greater incident rate in children
#4 autism (a self-centered or self-focused mental state with no basis in reality)
#5 Alzheimer’s disease
#6 old age
#7 anorexia
#8 constriction of the blood vessels
#9 blood clotting
#10 constriction of bronchials and other physical effects

Lower 5HIAA (serotonin metabolism) levels:
#1 suicide (especially violent suicide)
#2 arson
#3 violent crime
#4 insomnia
#5 depression
#6 alcohol abuse
#7 impulsive acts with no concern for punishment
#8 reckless driving
#9 dependence upon various substances
#10 bulimia
#11 multiple suicide attempts
#12 hostility and more contact with police
#13 exhibitionism
#14 arguments with spouses, friends and relatives
#15 obsessive compulsive behavior
#16 impaired employment due to hostility, etc.

All are exactly what patients and their families have continued to report to be their experience on these drugs since Prozac was introduced! These individuals are frantically searching for answers while this research sits right under our noses. Although this is a totally different picture than pharmaceutical marketing departments would have us believe, marketing claims and reality rarely have much in common.

Researchers tell us that five, ten or twenty years later it is not uncommon to find we have another thalidomide on our hands. Raising 5HT (serotonin) and lowering 5HIAA (serotonin metabolism) in such a high number of people can produce very serious, extensive and long term problems for all of society. Even more frightening for the future of our society is the rapidly rising widespread accepted practice of prescribing these drugs to small children and adolescents. This crucial medical research must be addressed openly, without delay, rather than remain buried in seldom read medical research documents as has been the case in the past with other mind-altering medications, once thought to be safe, which were subsequently prohibited by law.

Some information included in the book (424 pgs):
…serious long-term adverse physical and psychiatric side effects produced by elevated levels of serotonin …reported after effects: withdrawal, memory loss, sleep disorders, panic and anxiety attacks (adrenalin rushes), impaired concentration, bi-polar, diabetes, MS symptoms, mania, chronic fatigue, severe rebound depression, symptoms of Cushings Syndrome – moon face, looking or feeling pregnant, inability to handle stress, mood swings, etc.
…learn the cause of depression, manic-depression, panic, anxiety, OCD, psychosis, schizophrenia, etc.- understand mental illness as never before. …why False Memory Syndrome is so often being induced by these drugs and breaking up relationships …reports of compulsions for alcohol, sweets, NutraSweet sweetened drinks, spending and sex

SOURCE:- Drugs and the Brain by Solomon H. Snyder (Palmgrave Publishers, 1996- The scientific American Library

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