Loxitane® (loxapine)

GENERIC NAME: LOXAPINE – ORAL (LOX-uh-peen)
BRAND NAME(S): Loxitane

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

USES: This medication is used to treat symptoms of certain types of mental conditions. It acts in the brain to block chemicals involved with nerve sensitivity and improves concentration and self control.

HOW TO USE: Take with food or milk if stomach upset occurs, unless directed otherwise by your doctor. The liquid concentrate must be measured carefully and diluted with 4 ounces or more of water, milk, juice, or carbonated beverage. It can be mixed into applesauce or pudding. Do not dilute with coffee, tea, or colas – the medication may lose effectiveness. Take immediately after diluting. Take this medication as prescribed. Do not stop taking this drug suddenly without consulting your doctor. Some conditions may worsen if the medication is suddenly stopped. It may take up to two weeks for the full effects of this medication to be noticed.

SIDE EFFECTS: May cause drowsiness, dizziness or blurred vision. Other side effects include stomach upset, loss of appetite, headache, drooling, dry mouth, sleep disturbances or restlessness. If these effects persist or worsen, notify your doctor promptly. Unlikely but notify your doctor promptly if you develop: chest pain, a rapid heart rate, difficult or fast breathing, aching muscles and joints, tremors, rash, involuntary movements (such as chewing, puckering or a twitching tongue). If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: epilepsy, Parkinson’s disease, depression, heart disease, glaucoma, prostate trouble or difficulty urinating, alcohol and substance abuse history. Use caution performing tasks that require alertness. This medication can increase sensitivity to sunlight. Avoid prolonged sun exposure and wear a sunscreen and protective clothing if needed. Limit alcohol intake, as it may intensify the drowsiness effect of this medication. This medication can reduce sweating making you more susceptible to heat stroke. Avoid strenuous work or exercise in hot weather. The oral concentrate form can cause redness and irritation of the skin. Be careful not to spill it on your skin or clothing. Loxapine should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if loxapine is excreted into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all medications you use (both prescription and nonprescription), including: methyldopa, guanadrel, reserpine, guanethidine, other drugs used for mental conditions, amoxapine, metoclopramide, pemoline, promethazine, antidepressants. Also report use of drugs that make you drowsy such as: sleeping pills, sedatives, tranquilizers, narcotic pain medications (e.g., codeine), muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine). Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include severe dizziness; muscle trembling, jerking, stiffness, or severe uncontrolled movements; unusual tiredness or severe weakness; distressed breathing; and loss of consciousness.

NOTES: Do not share this medication with others.

MISSED DOSE: If you miss a dose, take it as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not “double-up” the dose to catch up.

STORAGE: Store at room temperature away from sunlight and moisture. Avoid freezing.

Last Editorial Review: 3/2/2005

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