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Switchng From Cymbalta To Pristiq

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I have been taking Pristiq for about 9 months and love it except for some side effects. It makes me grind my teeth all the time so bad and I now have cholesterol issues. I will actually be switching from Pristiq to Cymbalta next week. That is too bad about the weight gain. I am really worried about that. I heard that it decreases appetite though. Pristiq doesn't really affect your appetite at all. For me anyway. I didn't gain or lose weight. It took awhile for it to work (about 6 weeks to feel normal) but it really helped my anxiety alot. I wouldn't say that I was on top of the world happy but it definitly took the edge off of life.

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I have gained TONS of weight on Cymbalta and went to the Doctor today and he gave me samples of Pristiq. Who all has tried this? I will be taking it with Lamitical because of Bipolar? Any advice will be appreciated! I had been cutting back on my cymbalta for the past 2 weeks.

Tina,

i was on Cymbalta for over 5 years...over the last year it has decreased in working for me so my dr decreased me from 60 mg to 30 mg and then changed me to 50 mg of Pristiq...this is day 4 on Pristiq and i am still having withdrawal side effects from the Cymbalta...last night, i thought i was going nuts...the "brain zaps" and the "eye twitches" have drove me insane...can you share any withdraw symptoms that you may of had?

Thanks...

Cingqueen

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I was given Pristiq after taking Effexor XR 150mg for about 12 years. The Effexor had begun to cause headaches. Pristiq did nothing for me at all. I gave it a good try, about 6 months or so and nothing. Just blah. I will tell you that the switch from Effexor to Pristiq was seamless, no side effects. I am now taking Cymbalta and I am plumper than ever, thank you Cymbalta!

Edited by annamac

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I was given Pristiq after taking Effexor XR 150mg for about 12 years. The Effexor had begun to cause headaches. Pristiq did nothing for me at all. I gave it a good try, about 6 months or so and nothing. Just blah. I will tell you that the switch from Effexor to Pristiq was seamless, no side effects. I am now taking Cymbalta and I am plumper than ever, thank you Cymbalta!

I would seriously rethink the Cymbalta.....i have now been off of it almost 2 weeks and i am still having the "brain zaps"....they are getting better with each day but they actually make you think you are going crazy...made me really wanna pull my hair out...i have been a nurse for many years and seen many patients come through the ER that was having withdraws from illegal drugs and the Cymbalta made me feel like i was going through the same thing...let me know how you do....

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I started taking anti-depressants one year ago after years of struggling and trying to hide this disease...clinical depression. I just found out I was vitamin D deficient - more than the average person who lives in a place where seeing the sun is a rarity. I recently started taking 2000mg of vit D as directed by my doctor. This has helped my overall mood tremendously. My craving for certain foods has diminished. As for the meds:

1-From Cylexa - which left me with zero libido but it was incredible to start feeling back to my old self (it'd been a LONG time).

2-To Lexapro - the weight gain began and I felt like Lexapro stopped working after 4 months and felt those old familiar feelings again.

3-My family doctor then added Wellbutrin to Lexapro. The weight seemed to slide off over the first couple weeks, then I started to feel jittery and anxious...literally jumping out of my skin. I was constantly having heart palpatations and for the first time in my life (I'm in my early 30s) I had high blood pressure. I finally went to a psychiatry office, where I saw a physician's assistant. I highly recommend going straight to a highly respected professional if you are going to need medication. When I first went to the Psychiatry office the PA said the dose was too high.

4-So we tried Prozak. Talk about brain zaps. It was like being plugged into an electrical outlet. I cried - a lot.

5-So we tried Cymbalta. It worked! I felt amazing! Completely right. Except....the weight. I have weighed about 130 lbs my whole life. Now I weigh 150. That scale won't budge. I finally started counting calories which helps. But my metabolism is slow and I don't even recognize myself in pictures. Nothing busted more than a pound or two from the scale. My clothes are tight. And I now have cellulite on my arms and my belly. It's like a nightmare...anyone who has been fit their whole life with tight abs and arms who wakes up heavier each day would feel like a different person. This isn't me! It's so uncomfortable. I asked what my options are.

6-So we are trying Pristiq starting tomorrow. Anyone who has recently gone through this please let me know how you are making out.

I wasn't going to post but this site has helped me so much that I wanted to contribute. I don't feel as alone. Many people still think clinical depression is not real. I've heard people say they think it is a weakness. And you know what? Let them talk. I don't ever want anyone to know what it's like. I'd rather hear them criticize me for being on medication, seeing a therapist and being sensitive and overreacting than have them experience this. It's that bad for me...the struggling...the abuse of our bodies - whatever your indulgent pleasure may be - alcohol, smoking, drinking excessive caffeinated/energy drinks everyday or extreme exercising/dieting...it is a lonely, self-loathing, stuck in the past place to be. I am so thankful for these medications and my therapist. You can change. I did.

Edited by psfws11

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I started taking anti-depressants one year ago after years of struggling and trying to hide this disease...clinical depression. I just found out I was vitamin D deficient - more than the average person who lives in a place where seeing the sun is a rarity. I recently started taking 2000mg of vit D as directed by my doctor. This has helped my overall mood tremendously. My craving for certain foods has diminished. As for the meds:

1-From Cylexa - which left me with zero libido but it was incredible to start feeling back to my old self (it'd been a LONG time).

2-To Lexapro - the weight gain began and I felt like Lexapro stopped working after 4 months and felt those old familiar feelings again.

3-My family doctor then added Wellbutrin to Lexapro. The weight seemed to slide off over the first couple weeks, then I started to feel jittery and anxious...literally jumping out of my skin. I was constantly having heart palpatations and for the first time in my life (I'm in my early 30s) I had high blood pressure. I finally went to a psychiatry office, where I saw a physician's assistant. I highly recommend going straight to a highly respected professional if you are going to need medication. When I first went to the Psychiatry office the PA said the dose was too high.

4-So we tried Prozak. Talk about brain zaps. It was like being plugged into an electrical outlet. I cried - a lot.

5-So we tried Cymbalta. It worked! I felt amazing! Completely right. Except....the weight. I have weighed about 130 lbs my whole life. Now I weigh 150. That scale won't budge. I finally started counting calories which helps. But my metabolism is slow and I don't even recognize myself in pictures. Nothing busted more than a pound or two from the scale. My clothes are tight. And I now have cellulite on my arms and my belly. It's like a nightmare...anyone who has been fit their whole life with tight abs and arms who wakes up heavier each day would feel like a different person. This isn't me! It's so uncomfortable. I asked what my options are.

6-So we are trying Pristiq starting tomorrow. Anyone who has recently gone through this please let me know how you are making out.

I wasn't going to post but this site has helped me so much that I wanted to contribute. I don't feel as alone. Many people still think clinical depression is not real. I've heard people say they think it is a weakness. And you know what? Let them talk. I don't ever want anyone to know what it's like. I'd rather hear them criticize me for being on medication, seeing a therapist and being sensitive and overreacting than have them experience this. It's that bad for me...the struggling...the abuse of our bodies - whatever your indulgent pleasure may be - alcohol, smoking, drinking excessive caffeinated/energy drinks everyday or extreme exercising/dieting...it is a lonely, self-loathing, stuck in the past place to be. I am so thankful for these medications and my therapist. You can change. I did.

Your post is very informative and I hope you will post how you're doing with the Pristiq. I'm on Celexa and have been for well over a year. Its not helping at all anymore and I think it actually increases my anxiety. I have a lot of agitation. When I first started AD's I was put on Prozac and it was wonderful but over the years it stopped working. I gained 40 lbs taking Prozac and its taken me 10 yrs to get rid of it. I don't want to put it all back on so I understand completely how you feel.

Thanks

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I have never posted to a forum like this before. To give you some background on myself, I am 32 years old, single mom (divorced three years ago), full time college student (majoring in special education). I graduated HS in 97, and decided not to go to school right away, ended up married, then had my daughter, and thought I would wait to go to school until she was older and in school, the year she was to start K my son was born, so I made the same decision. Finally last October I enrolled in online classes, full time, while also working 50+ hours per week, and maintaining my children's schedules because I refuse to do anything that takes away from their childhood. This was very stressful and created the problem of no sleep for me, because I would only work on my school work when they were sleeping at night. I maintained perfect grades and all that. I should also include that upon moving back to my home state of Arkansas after my divorce I soon began datiing my best friend's younger brother, we have been together for a little over two years. Obviously having known his family my entire life I have always been very close with them. His father passed away March 2010 of pancreatic cancer, which devasted not only him and his family, but also my children and I (as they had gotten very attatched to him). Then December of 2010, his grandmother also passed away, which further depressed me, then February of this year my grandmother passed away, I assisted in her care during her final days at home... as if all of that wasn't enough, I lost my job in April, had to move into a tiny apartment, and figure out how to make it with very little income. The first week of June my children left to spend the summer with their father who lives in another state. I had never been away from them longer than Christmas Break and sank further into depression. My daughter had a very hard time being away from me, and decided at the end of July to come home. My son (who is 6) told me after she came home that he wanted to live with his dad. I had always promised both of them that if they ever decided that is what they wanted to do, that I would let them. I never wanted them to feel that they were "stuck" with me, or that they were caught in the middle. My son had no memories of his father since he was so young when we separated, and didn't have a "real" bond with him. I was totally destroyed by his decision, but I did not let him know that, I didn't want to make him feel bad, so I told him that if that's what he wanted, then I would let him, that I wanted him to be where he felt he would be happiest, and that I would love him the same no matter where he lived. I pushed everyone away, except my daughter (11) whom I clung to, I didn't want to be away from her for a second. I would go days without leaving the house, or speaking to anyone other than her (not even my boyfriend). I would make up excuses to not have people come to my house, I didn't eat, didn't sleep, didn't do anything, I just wanted to stay in my bedroom and hide from the world. I cried nonstop, I couldn't sleep for all of the anxiety over things that might happen if I weren't with my son. I was consumed by my depression and by my anxiety. I finally realized that it was time to see the doctor.

My doctor put me on cymbalta for the depression and an anxiety medication to use at night so that I would sleep. The cymbalta gave me a headache for the first week or so, caused hot flashes, nausea, and all of those other nasty side effects. After two weeks I went back for my follow up, he decided to increase the dosage and since I still wasn't sleeping, he took out the anxiety medication and placed me on ambien, and told me to come back in a month. After the initial side effects from the cymbalta subsided, I did stop crying all of the time, and I lost about 15 pounds. However, I still wasn't me. I would go places if I were forced to, and talk if someone MADE me speak, otherwise, I still sat trapped inside my head with my thoughts, and instead of feeling sad, I just felt blank. I had no mood at all. I still made excuses to keep people from coming over, and still had to force myself to get up, take a shower, and still would generally just put pajamas back on. Finally it was time for another follow up, which was good because I was also sick.

Tuesday (the day after Labor Day) I went back to the doctor with a horrible sinus and ear infection (which I am very prone to) this was the worst ear infection I have ever had, the pain was off the charts. I told him about my mood, and that I still wasn't sleeping (even taking benadryl with ambien didn't allow more than 2-3 hours per night). He said it was time to try something different, that he WAS going to make me feel better, and that I WOULD be me again.

He gave me samples of Pristiq and of Lunesta (along with a Zpack for the infection). I started taking Pristiq that day (I had forgotten to take my cymbalta that morning). I took it around 1 PM that day. I got a horrible headache, my ears were ******* me (to the point that as I layed in bed I prayed for my ear drums to rupture just to get some relief) and I guess due to the combo of pain and taking the Pristiq that late in the day, even with nighttime cold medication, and the lunesta I did not sleep at all that night. The following day I still had the same problems with headache and ear pain, but I took the Pristiq at 6 AM when I got my daughter up for school. I was still in a great deal of pain that night, but took the Lunesta and only tylenol and motrin for the pain and was able to sleep, and I slept ALL night.

Yesterday was day 3 on Pristiq, and I felt much better, no headache, and the antibiotics were finally working their magic on the infection. I actually got up, took a shower, got dressed and went "window shopping" because I WANTED to be out of the house. I also had conversations with people, and had company over to my house.

Today, day 4... I must say I feel AMAZING! I woke up after a full nights sleep, went outside and talked to neighbors, I've talked to people more today than I have in months, and I feel... brace yourself.... HAPPY, and GOOD. I am so excited about how well this medication is working for me, I hope that it continues, I am ready to be ME again, and for the first time in a very long time, I can see that it is very possible.

I am hoping that the weight loss continues on Pristiq like with the cymbalta. But I am just so excited about all of this. Yes, there were side effects from coming off of cymbalta (I believe that's what the headache was from) but I am just thrilled with how I feel now. I am even going on vacation! I leave to go to the beach for 4 days tomorrow, and I'm excited! Not just that, I'm excited about being excited LOL.

I know that things can happen and medications stop working. I was misdiagnosed as being Bipolar when my son was an infant and was placed on lots of various medications, in reality I have ADHD, but the other medications (the wrong ones) that I had taken in the past killed my thyroid, so now my daily medications include Synthroid, Adderall, Pristiq, Lunesta, and Cingulair. I know that I will get better, I also know that there will still be bad days, but I finally feel like I can handle it.

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On 9/9/2011 at 10:01 AM, justme4689 said:

I have never posted to a forum like this before. To give you some background on myself, I am 32 years old, single mom (divorced three years ago), full time college student (majoring in special education). I graduated HS in 97, and decided not to go to school right away, ended up married, then had my daughter, and thought I would wait to go to school until she was older and in school, the year she was to start K my son was born, so I made the same decision. Finally last October I enrolled in online classes, full time, while also working 50+ hours per week, and maintaining my children's schedules because I refuse to do anything that takes away from their childhood. This was very stressful and created the problem of no sleep for me, because I would only work on my school work when they were sleeping at night. I maintained perfect grades and all that. I should also include that upon moving back to my home state of Arkansas after my divorce I soon began datiing my best friend's younger brother, we have been together for a little over two years. Obviously having known his family my entire life I have always been very close with them. His father passed away March 2010 of pancreatic cancer, which devasted not only him and his family, but also my children and I (as they had gotten very attatched to him). Then December of 2010, his grandmother also passed away, which further depressed me, then February of this year my grandmother passed away, I assisted in her care during her final days at home... as if all of that wasn't enough, I lost my job in April, had to move into a tiny apartment, and figure out how to make it with very little income. The first week of June my children left to spend the summer with their father who lives in another state. I had never been away from them longer than Christmas Break and sank further into depression. My daughter had a very hard time being away from me, and decided at the end of July to come home. My son (who is 6) told me after she came home that he wanted to live with his dad. I had always promised both of them that if they ever decided that is what they wanted to do, that I would let them. I never wanted them to feel that they were "stuck" with me, or that they were caught in the middle. My son had no memories of his father since he was so young when we separated, and didn't have a "real" bond with him. I was totally destroyed by his decision, but I did not let him know that, I didn't want to make him feel bad, so I told him that if that's what he wanted, then I would let him, that I wanted him to be where he felt he would be happiest, and that I would love him the same no matter where he lived. I pushed everyone away, except my daughter (11) whom I clung to, I didn't want to be away from her for a second. I would go days without leaving the house, or speaking to anyone other than her (not even my boyfriend). I would make up excuses to not have people come to my house, I didn't eat, didn't sleep, didn't do anything, I just wanted to stay in my bedroom and hide from the world. I cried nonstop, I couldn't sleep for all of the anxiety over things that might happen if I weren't with my son. I was consumed by my depression and by my anxiety. I finally realized that it was time to see the doctor.

My doctor put me on cymbalta for the depression and an anxiety medication to use at night so that I would sleep. The cymbalta gave me a headache for the first week or so, caused hot flashes, nausea, and all of those other nasty side effects. After two weeks I went back for my follow up, he decided to increase the dosage and since I still wasn't sleeping, he took out the anxiety medication and placed me on ambien, and told me to come back in a month. After the initial side effects from the cymbalta subsided, I did stop crying all of the time, and I lost about 15 pounds. However, I still wasn't me. I would go places if I were forced to, and talk if someone MADE me speak, otherwise, I still sat trapped inside my head with my thoughts, and instead of feeling sad, I just felt blank. I had no mood at all. I still made excuses to keep people from coming over, and still had to force myself to get up, take a shower, and still would generally just put pajamas back on. Finally it was time for another follow up, which was good because I was also sick.

Tuesday (the day after Labor Day) I went back to the doctor with a horrible sinus and ear infection (which I am very prone to) this was the worst ear infection I have ever had, the pain was off the charts. I told him about my mood, and that I still wasn't sleeping (even taking benadryl with ambien didn't allow more than 2-3 hours per night). He said it was time to try something different, that he WAS going to make me feel better, and that I WOULD be me again.

He gave me samples of Pristiq and of Lunesta (along with a Zpack for the infection). I started taking Pristiq that day (I had forgotten to take my cymbalta that morning). I took it around 1 PM that day. I got a horrible headache, my ears were ******* me (to the point that as I layed in bed I prayed for my ear drums to rupture just to get some relief) and I guess due to the combo of pain and taking the Pristiq that late in the day, even with nighttime cold medication, and the lunesta I did not sleep at all that night. The following day I still had the same problems with headache and ear pain, but I took the Pristiq at 6 AM when I got my daughter up for school. I was still in a great deal of pain that night, but took the Lunesta and only tylenol and motrin for the pain and was able to sleep, and I slept ALL night.

Yesterday was day 3 on Pristiq, and I felt much better, no headache, and the antibiotics were finally working their magic on the infection. I actually got up, took a shower, got dressed and went "window shopping" because I WANTED to be out of the house. I also had conversations with people, and had company over to my house.

Today, day 4... I must say I feel AMAZING! I woke up after a full nights sleep, went outside and talked to neighbors, I've talked to people more today than I have in months, and I feel... brace yourself.... HAPPY, and GOOD. I am so excited about how well this medication is working for me, I hope that it continues, I am ready to be ME again, and for the first time in a very long time, I can see that it is very possible.

I am hoping that the weight loss continues on Pristiq like with the cymbalta. But I am just so excited about all of this. Yes, there were side effects from coming off of cymbalta (I believe that's what the headache was from) but I am just thrilled with how I feel now. I am even going on vacation! I leave to go to the beach for 4 days tomorrow, and I'm excited! Not just that, I'm excited about being excited LOL.

I know that things can happen and medications stop working. I was misdiagnosed as being Bipolar when my son was an infant and was placed on lots of various medications, in reality I have ADHD, but the other medications (the wrong ones) that I had taken in the past killed my thyroid, so now my daily medications include Synthroid, Adderall, Pristiq, Lunesta, and Cingulair. I know that I will get better, I also know that there will still be bad days, but I finally feel like I can handle it.

You've given me new hope and I'm hoping that you've only gotten better since this post ❤️

-Sam

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