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1. Switching from Pristiq to Effexor XR and 2. Withdrawal (No negative discontinuation stories please)

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Posted (edited)


After experiencing a MAJOR bout of depression I have made the switch (as of last Friday) from 100mg Pristiq to 75mg Effexor XR. (Under the supervision of a GP). 

I started taking Pristiq after MDD in 2016. Prior to that I was on Zoloft for many years however it was no longer effective. I had been on Effexor XR for a few years prior to having children and was very effective. It was suggested as an option in 2016 but I had such a horrendous time coming off it (pregnant so went cold turkey) that I was terrified of touching it again. (Nb: It was a cold turkey Effexor XR cessation met with cold turkey smoking cessation plus pregnancy hormones so was never going to be good.) Hence, in 2016, I made the decision to take Pristiq instead.

Fast forward 3 years and I've experienced a crippling bout of depression. Out of sheer desperation (remembering how well it worked previously) have switched back to Effexor XR. (Direct switch).

Felt no different for the first 3 days (I.e. No side effects). Day 4 (yesterday) felt absolutely horrendous and insane. Uncontrollable bout of crying at work. (Embarassing much.) Later today (Day 5) I felt pretty awesome. Still feel heavy in the body.

My questions in relation to this are:

1. Has anyone else made a direct switch from Pristiq to Effexor XR and did you have a similar experience in the first week? 

2. Is it possible to experience discontinuation symptoms even though they are both SNRI's?

2. Can anyone tell me a positive discontinuation story? (In case a) one day it stops working or b) I can one day go AD free.) It would be good to know a person doesn't have to go through Hell to come off it. (No negative tales of experiences please).


Edited by Sane19
Missed a sentence

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Pristiq 100mg to Effexor 75mg is crazy! You’re most likely having withdrawals. Pristiq is much stronger than Effexor. It’s like getting your dose cut in half!

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My guess is that if you have 10 responses you will learn 10 different  discontinuation stories.  I'm coming off Pristiq right now, it is day two so too early I feel to tell.  

Wishing you the best with the Effexor and the switch. 


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I swapped from Pristiq to Effexor XR. 

Didn't feel any withdrawals, but I went frrom Pristiq to 75mg of Effexor XR. What i noticed is that on Effexor, my anxiety attacks were much less, but depression was more noticeable. I gave that feedback to my psychiatrist, and they increased my dosage to 150mg. Been on that for about a week, and it seems to be working well for me, for now. 

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