Jump to content

Recommended Posts

I've done some searching on the forum and see a lot of posts with some crazy side-effects. From nausea and vomiting, weight loss, brain fog, etc.

Has anyone taken or is taking this and not had any serious side effects?

Share this post


Link to post
Share on other sites
16 minutes ago, ItsNeverEnough said:

I've done some searching on the forum and see a lot of posts with some crazy side-effects. From nausea and vomiting, weight loss, brain fog, etc.

Has anyone taken or is taking this and not had any serious side effects?

I can not recall having any real bad side affects on Trintellix.  My insurance quit paying for it and I could

no longer afford to take it, is why I quit taking it.  Best of luck my friend

 

Share this post


Link to post
Share on other sites

So I've been taking it for almost 2 weeks now. No side effects yet. I've done some research that suggests increased cognitive function after 8 weeks or so, but slightly flawed as to whether it is any different from any other anti-depressant relieving the impairment caused by the disease itself. 

That is appealing to me, as the main reason I visited the doctor recently was due to my lack of focus, but it appears he tends to focus on my depression and anxiety symptoms (and maybe he had the above mind? probably not, anxiety which only reappeared upon taking new medications). Focus has become the most important thing for me to treat because I can see it literally making my life fall-apart (and I can't imagine how that wouldn't trigger depression). I know that concentration and motivation issues are symptoms of depression, but if treatment is working shouldn't those symptoms go away? Why would they get worse?

Have either of you noticed any increase in concentration and focus on it? 

As for the cost, I signed up for a saver program (not the coupon as that is only temporary) on their website that may be worth looking into. With it, you pay only $10. I had to work with my pharmacist to get the discount to work (they ended up making phone calls). 

Edited by ItsNeverEnough

Share this post


Link to post
Share on other sites

I had intense, consistent vomiting on Trintellix about one hour after I'd take it, every time. Too much vomiting, couldn't tell if it was affecting mood haha. Discontinued pretty fast.

Share this post


Link to post
Share on other sites

i started Trintellix 6 weeks ago after reducing off an 18 year run with Effexor.  I had no noticeable side effects whatsoever from the Trintellix which was really surprising from me because i am quite sensitive to meds.

I was feeling really well until about 10 days ago when i felt like i was plummeting - I am unsure if it's delayed reaction to effexor w/d or the trintellix is just not cutting it - i was on 10mg for one week, then 15 mg for 4 weeks and 20 mg the last week.  3 days ago my doc added in Valdoxan - I am still up and down, feeling some side effects from Valdoxan - mainly fatigue  - but a different type of fatigue i was feeling when i was plummeting.

Share this post


Link to post
Share on other sites

I have another update on this. Still taking 10mg. Anxiety has been gone for sometime and my focus returned shortly after my last update. 
I feel normal except my mood has been horrible. I don't think Trintellix is completely helping me with my depression like Sertraline was.

I am now being bumped up to 20mg. I haven't had any side-effects, and I'm hoping an increase doesn't show any new ones. 

@supergirl How is it going so far, are you still taking Trintellix?

Share this post


Link to post
Share on other sites
8 hours ago, ItsNeverEnough said:

I have another update on this. Still taking 10mg. Anxiety has been gone for sometime and my focus returned shortly after my last update. 
I feel normal except my mood has been horrible. I don't think Trintellix is completely helping me with my depression like Sertraline was.

I am now being bumped up to 20mg. I haven't had any side-effects, and I'm hoping an increase doesn't show any new ones. 

@supergirl How is it going so far, are you still taking Trintellix?

trintellix turned out not to be the drug for me - i came off over a couple of weeks at the same time cross tapering onto lexapro.  Have kept me on the valodoxan as it apparently augments it nicely..

have been on lexapro 10mg for 2 weeks, but think it probably needs to go - seeing my dr tomorrow but i think she wants to give it 4 weeks before increasing - given that i am also on valdoxan

Share this post


Link to post
Share on other sites

I've been on 20mg of Lexapro for about a year, felt like its starting to poop out, so the doc recommended Trintellix. For me it was awful. I actually stopped taking it tonight after about 13 days. I took 5mg for 8 days, then 10 mg for 5 days, while tapering down the Lexapro. I felt like I was going to crawl out of my skin. Could not relax, could not focus, could not work. Thought I might be able to get over the hump of the transition, but could not. I swear I feel better tonight after stopping. I know everyone gets different results, but I could not handle this one. 

 

Share this post


Link to post
Share on other sites
9 hours ago, jeffreyd said:

I've been on 20mg of Lexapro for about a year, felt like its starting to poop out, so the doc recommended Trintellix. For me it was awful. I actually stopped taking it tonight after about 13 days. I took 5mg for 8 days, then 10 mg for 5 days, while tapering down the Lexapro. I felt like I was going to crawl out of my skin. Could not relax, could not focus, could not work. Thought I might be able to get over the hump of the transition, but could not. I swear I feel better tonight after stopping. I know everyone gets different results, but I could not handle this one. 

 

Sorry to hear that. It is a shame when the effectiveness of a medication fades. Sometimes I wonder if a medication is doing anything for me except serving as a placebo. I would have stayed on Sertraline if it weren't for the issues I was having focusing.

Share this post


Link to post
Share on other sites
On 1/15/2019 at 1:47 PM, ItsNeverEnough said:

I've done some searching on the forum and see a lot of posts with some crazy side-effects. From nausea and vomiting, weight loss, brain fog, etc.

Has anyone taken or is taking this and not had any serious side effects?

I'm new here and saw this post. I have been in Trintillex for 6 weeks and have had issues with nausea, vomiting, and weight loss. I have not had brain fog - in fact, until recently, this episode of depression was largely an issue with cognitive functioning/executive functioning skills and my doctor said that this medication was especially good with this. I will share that during the first 2-3 weeks of taking the medication, I did not notice any nausea, vomiting, or generally unsettled tummy issues. Along about week 4 I did - though the stomach flu was going around. I was taking my medication in the AM and no amount of eating to try and reduce the side effects helped. I finally started taking it at night and it has reduced the nausea/unsettled tummy but I'm not having other issues (lots of crying and emotions - more of what previous episodes of depression have been like) and don't think this medication is for me. Finally, I have had a complete loss of appitite. It may be the Straterra I am taking (a known side-effect) but again, the combination of side-effects and new emotional issues has me thinking this is not the medication for me.

Prior to Trintillex, I was on Cymbalta for over 10 years and it was so dependable...I wish it still worked. I hate it when my meds are off.

Share this post


Link to post
Share on other sites

Welcome @AKGrown!

Thanks for sharing your experience with it. My doctor seemed to believe it would also help me with my cognitive function in regards to focusing. Lately, I am starting to notice nausea sometimes shortly after taking the medication. It is bearable but hard to ignore. 2 times however it was much worse, and napping was the only thing that helped. I don't have an idea of what's different day to day, but taking it after a solid meal and limiting caffeine seems to help. While I didn't see any interactions with caffeine in the paper work, I've noticed an increased sensitivity to caffeine now. Drinking coffee will worsen the nausea when I get it, and do exactly the opposite of what it normally does, destroying my focus.

I haven't had any loss in appetite (I wish). I seem to eat more and give into cravings easier. I've read around that doctor's will sometimes prescribe Zofran along with it to control vomiting, but if you feel its not for you, it might not be worth pursuing.

For me, if the nausea gets worse, or this doesn't work out, I am considering dropping anti-depressants all together and just fighting through the old way.

Share this post


Link to post
Share on other sites

I"m a new person on here, but came looking for some thoughts on Trintellex.  Glad I found the question, even though it is older.  I'll post a couple comments here hoping not to hijack the thread.  Maybe a new post is in order? 

Brief background - middle aged professional male, 15 lbs overweight, not actively exercising and not eating well at the moment.  Last year, was active and lighter so I'm not stacking the cards in my favour at the moment.  

I'm in the middle of prepping for the CFA Level 2 exam for this coming June.  History of depression and GAD which I was treated for then through therapy and medication, have not been on medication for either condition for about 5 years.  3 years ago my psych doc and I began addressing my ADHD so I take 40mg (in 10mg increments) per day of methylphenidate along with seeing a CBT therapist (The Happiness Trap is a good example of the intent of my therapy). 

Began having clearly depression symptoms in January and after about 6 weeks decided I to see my psych doc about it.  Lethargy, sadness, hopelessness, sleeplessness, irritability.  Things I hadn't felt acutely for a few years and I just couldn't self-manage through them this time.  It was odd, but then again, clearly something wasn't right.  One other thing that gave it away was that my focus even following taking my methylphenidate was lacking...as if the depression was dampening the beneficial effects, like I was in a fog in a way I hadn't been in a long time.

Psych doc suggested trintellex as it was newer and had fewer side effects than the antidepressants I had used many years ago. 

5m for the first week then ramped up to 10mg where I stayed for a month.  Some of the benefits below;

  • very early improvement in "mood" - I "thought" I began to feel better after 4-5 days of taking it.
  • mood improvement helped sleeplessness - could get full 7-8 hours of sleep consistently and this began happening within the first week.
  • focused and engaged at work
  • Methylphenidate worked as expected
  • Sadness, hopelessness, etc faded away...they were present but "rolled off my back" more like they used to.

The couple of things that stuck as negatives were

  • Sour stomach about an hour after taking it.  Occurred about 60% of the time.  I could eat food and that helped but I had to figure out the timing on this as I usually didn't neat until 10am.  Having a yogurt or a protein drink helped this.
  • Slight sexual dysfunction.  Don't get me wrong here, these side effects were lightyears better than some of my prior experiences (wellbutrin) but it was present.  No ED but some challenges in "finishing the job".  Wife and I have a very active intimate life so both my wife and I noticed and this got in the way.
  • Cost - it's expensive.  With approval by insurance and with the coupon it was still over $200.  Not a deal breaker for me but I can see how it can be for others.

I'm sorry this is getting so long, but the reason I came here was because to address the sexual dysfunction, my doc and I opted to try 5mg again (instead of 10mg) and then have viagra as an option. 

I began only taking 5mg last Saturday (5 days ago), and while some of the "finishing the jobs" issues have gone away, it seems like my mood has gotten somewhat worse.

Is it too soon to feel the medication fade like that?  It seems to early but considering I felt the positive effects of trintellix pretty quickly, maybe the lower dosage can be felt quickly as well?

Share this post


Link to post
Share on other sites

@c4n4ry Hi and welcome to the forums!

So sorry to be seeing this post so late. I believe there must of been a notification issue.
I believe you are right about feeling it quickly, I felt the same way in the beginning. I'm a tad jealous it worked so well for you, save for the negatives. For me, the positive (if any) were barely noticeable.
Seeing as it is months later, if you see this post, let us know how you are doing now -- if you are still taking it or not.

I've stopped taking mine sometime in early May. In the beginning of taking it, it did feel like it was doing something, but just not enough. Then I kept getting bumped up in mgs, but nothing ever changed or felt different. I believe what I did feel in the beginning was actually just the distancing of previous anxiety caused by medications prior.

I didn't have any issues with sexual function, I did have the nausea though. To summarize for me, it wasn't worth it to suffer through nausea everyday (taking naps in the middle of the day, or being short with my wife or kids) for something that doesn't appear to be working well. And since my recent trails with anti-depressants have gone so poorly, I've just given up on them all together. So I haven't take any medications since I quit Trintillex. I was afraid to quit, because I read horror stories where people were basically stuck on it due to withdraw symptoms. Fortunately through some luck, I did not suffer from withdraws (probably because, well, it wasn't working for me). 

Share this post


Link to post
Share on other sites

c4n4y Did you find the nausea subsided any with the lower dose of 5 mg?  I quit taking 10 mg because it felt like my stomach was going to burn out of me.  Very uncomfortable.  I did find that was the only bad effect and the improvement in my MDD & Anxiety  was good.  I recently started taking it again because I was so bothered by the falling/dropping sensation from my anxiety.  I have tried anti nausea pills and Gaviscon antacid to help, but nothing really stops the stomach issue completely.  I find the sexual effects of Trintellex to be minimal, but not zero. I was also bothered by finishing the job. I must say that my falling/dropping sensation was gone in 2 days, maybe I could use a lower dose and avoid the side effects. I'll. talk to my doc about that soon.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

×
×
  • Create New...