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I am curently on 225mg XR Venlafaxine. The doctor wants me to go on 300mg so I am going to give this a try but I have a question which is puzzling me. 

Caffeine raises dopamine and blocks adenosine and is a stimulant

Venlafaxine / Effexor also raises dopamine

Is the effect the same ?

Does Venlafaxine have the same effect as caffeine at 300mg ?

Or does it feel different ?

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Hi Bliizard -- There's various issues with this situation.

Firstly, Venlafaxine is an SNRI anti depressant where caffeine isn't. Venlafaxine blocks the NE and 5 HT transporters in the brain with a half life of about 10 hours.

Caffeine has a half life of a few hours and the effects of caffeine start to reduce within an hour, hence why coffee drinkers drink regular cups of coffee, where Venlafaxine is one to two tablets a day.

Adenosine is an oxygen transporter and caffeine has no effect on the blockage or release of this transporter.

So, in answer to your question, caffeine will not have the same effects as Venlafaxine.


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In my experience, any SSRI or SNRI will actually reduce dopamine activity because of the overall percentage increase of serotonin and norepinephrine which then begin acting at the receptor sites normally occupied by dopamine.

Basically, dopamine gets drowned out / diluted.




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