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Medication For Anhedonia


iamnumb

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Secondary question:

has anyone successfully added a serotonin 5ht2c antagonist (which leads to dopamine inhibition) like nortriptaline or miterazapine to reverse SSRI anhedonia/apathy? Seen mixed success online.

also, I refuse to add low dose anti-psychotics like olanazipime to block those receptors.

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7 hours ago, CF900 said:

all nortriptyline ended up doing for me was sexual anhedonia, granted i was only on bupropion along side it.

I found the SSRI to be a critical part of the combo, there's something interesting about the synergy of the two.

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  • 4 weeks later...

 

 

 

 

 

The process of recovery from anhedonia is primarily austerities.
It was nice to take a tablet of happiness and quickly and painlessly return to the world of the living. UNFORTUNATELY EASY SOLUTIONS OUT OF anhedonia NO!

It should be avoided until a satisfactory well-being:


Alcohol-alcohol destabilizes the opioid system in the brain.
Nicotine Nicotine -nadużywanie destabilizes the flow of acetylcholine and dopamine in the brain.
Pornography, compulsive ************* / sexual addiction extremely harmful compulsion, reduces the levels of dopamine and endorphins in the reward system in the brain also leads to dysfunction cycle of serotonin in the hippocampus. konsekwencje- deep depression with anhedonia, neurotic states running with a very strong anxiety, fear, insomnia, high risk of suicide. If left untreated, often leads to impotence.
Kawa in excess causes severe anxiety reaction rebound is impaired concentration, headaches, sleep disorders.

The drugs I will not even mention - they are determined by one słowem- death!



When we will feel as we expected we do not need to return to bad habits.
Well, unless you want to experience again hell of anhedonia.

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  • 1 month later...

back on these forums since a long time... i think of all the meds ive tried fluoxetine is the one that made me feel the most "real". in the sense of being there, immersed, enjoying going to the cinema or stupid stuff like that which i had never understood before. probably stimulated arousal. i ahve been trying a lot of other stuff and stimulants (reboxetine, bupoprion, moclobemide, tianeptine, modafinil, methylphenidate), and while they all did their thing, none of them (maybe with the exception of high dose, constant moclobemide at his peak) has given me anything similar.

 

now the problem is fluoxetine is a plague on the genitals. i still suffer (7years later) from genital anaesthesia.

 

tlddr: what is a good adjunction to fluoxetine to counter the sexual side effects?

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  • 5 months later...
  • 1 year later...

I strongly suggest anyone suffering Anhedonia get tested for Lyme, as well as CIRS (mold exposure).. Anhedonia is a result of  HP axis dysregulation caused by inflammatory cytokines. Adding psych meds is just perpetuating the disaster!  Everyone always wants the "magic pill" solution. Sorry to tell you it doesn't exist! 

Edited by jarmenti
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  • 1 year later...

Hi all! I will have to take the time to read through the various posts when I have time (currently busy with college courses). I remember when the Anhedonia forum was first created so glad to see it still going. I had severe anhedonia from around 2012 through 2016. I remember I told my psych that I felt like it I had reached an end, as far as getting any worse around the end of 2016. Then, from 2017-2019 is has slowly been fading. Unless you have a really good psychiatrist (like I presently have) I think it's something that is not easily fixed with medicine. There are 3 meds have shown to help me, from least to greatest of help: Abilify, Modafinil and stimulants. The issue with stimulants is that most doctors will not prescribe them unless you've been suffering from it for many years and then they still might not. They've help me better than anything else. Note, I found at low doses to be effective, only if it's a light stimulant effect. At higher doses and stronger stimulant effect, it seems to make matters worse, so the dosage is sort of an art, you have to play with it......That and time is the only thing that has seems **** the anhedonia. It's a horrible symptom of depression, that you all are suffering from so I definitely hope you all get some relief soon. At this point, my interest level has slowly started coming back.  I spend sometime hours in my studies where that would have been impossible just a year or so ago. One thing though, and it's just my opinion but I think I'm right about this. The anhedonia will not won't last forever. It might be almost a decade lost like in my case  (or god forbid longer), but it will eventually start to fade and go away. It just takes a long time for many. But again, those 3 meds all helped me so if you take meds, definitely give them all a try and play with the dosage as much possible before moving on. Hopefully this info helps somebody!

Edited by james555
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  • 1 month later...

@james555 can u  tell , some information/ experience u have it  with AGOMELATINE ......DOes it work? My anhedonia started with SSRI treatment , and remained same though my doc changed drugs to SNRI and Bupropion. I am going to try for agomelatine...is it effective ? ... I also heard that Pramipex is useful in this?

Is there any other dopamine agonist helps??

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  • 2 months later...
On 4/2/2020 at 11:17 AM, SSRI said:

@james555 can u  tell , some information/ experience u have it  with AGOMELATINE ......DOes it work? My anhedonia started with SSRI treatment , and remained same though my doc changed drugs to SNRI and Bupropion. I am going to try for agomelatine...is it effective ? ... I also heard that Pramipex is useful in this?

Is there any other dopamine agonist helps??

Hello! I apologize! I understand very well what you all are going through and feel like I should help and give any good info that might help you ASAP. So sorry! I need to change my email address on here so I get notifications of replies, will try that after I post this.

@SSRI I have no experience with Agomelatine. Sorry! My post was way back in February so lots has happened and I've learned more about my depression and what helps and what doesn't.

In my opinion, forget  those dopamine agonist. If you have treatment resistance depression w/ anhedonia (I can't speak for other types) you need a CNS stimulant and maybe take something like Wellbutrin along with it. But the CNS stimulant is key. There are a lot of bullshit articles on how stimulants are *bad*, mostly in the media. But, taken as prescribed, they are safer and 10x's more effective for people with TRD. If you feel as like it's more of a dopamine problem, then a CNS stimulant is probably as good as you get. Make sure you take the XR type though. Those work like any other add-on or AD like Abilify, etc... The IR Immediate Release type isn't consistent enough to fully do the job IMO. In my case, I am 100% sure it's low dopamine that's cause my TRD/anhedonia as well as some other symptoms like severe concentration issues and loss of all emotions. If those symptoms sound close to what you are experiencing you need to find a good psych that will listen to you and prescribe what works for you. 

That being said read this article, it's a decent article and has some good points: https://mentalhealthdaily.com/2014/03/13/taking-adderall-for-treatment-resistant-depression/ The article does makes a good point of how "not everyone should be on a stimulant for depression." so there are cases where it's not going to work. Nothing is perfect. But your odds are better with one if you have TRD w/ low dopamine/ahedonia. I know b/c I have suffered from it for 8+ years with hardly any help. It's not a coincidence that I just starting feeling well again almost as soon as I was prescribed one.

 

Just my opinion, but I do not think the type of CNS stimulant matters, as long as it's works similarly, so I wouldn't get hung up on finding the right stimulant. Finding the right dosage is important though so it'll be trail and error. Watch out for caffeine and drink very little, it will cause it not to work well...just my experience....

I wouldn't recommend Pramipex  as I don't know enough about it. But if you are looking for a med that will help with your dopamine issues / ahedonia then again, a stimulant is as good as it gets. It'll get you well in my opinion. It's eliminated my concentration issues, anhedonia and my loss of emotion within a a few weeks of finding the right dosage.  Even at low doses I saw an improvement. Hope that helps and you get well soon. Took me 8 years until a pysch decided to prescribe this type of med for me. I should have been sooner but happy I found something. For anhedonia, it's the only answer IMO. I stress my opinion. But two things or it won't work...take as prescribed (that's very important, never take more than prescribed) and be patient and find the highest dose that doesn't cause side effects. Hope this helps!

 

Edited by james555
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  • 1 year later...
On 5/20/2017 at 4:42 PM, CF900 said:

Has anybody tried nuedexta?

I have just started taking it.

It’s DMX with an added agent to keep DMX from quickly converting into its metabolite, which is very poorly crosses into the brain and does not have all the same properties as DMX.

DMX (and Nuedexa) is an NMDA antagonist and sigma1 agonist just like Ketamine, although this one does a bunch of additional things, which may be less prominent, but still.
 

I just wonder whether it’s dose indicated for PBA is sufficient enough for causing dendritic spines growth on neurons as what Ketamine does, because it is this very effect that very potently promotes neuroplasticity, i.e., speaking in the simple terms, what’s broke and causing Anhedonia could grow around and create new neural connections.

(Although Ketamine may also work by acting on NMDA and sigma1 receptors directly, or in some other ways, which are not yet discovered).

 

Have you tried Nuedexa?

Did it help any for you?

If so, what dose were you on?

 

Edited by Deter
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