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Answers To Curing Anhedonia/numbness/apathy, No. 2


Lioninwinter

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So im doing the Ketamine treatment. This thing is the real deal for depression. The fog is gone, music is enjoyable again, and the big kicker is, im not on any regular medication now.

Im only on day 2 of 5 sessions of ketamine, which only take an hour or two of feeling intoxicated, but then the next day my depression is just gone.

Time will tell if its lasting, but going by the research its very promising.

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So im doing the Ketamine treatment. This thing is the real deal for depression. The fog is gone, music is enjoyable again, and the big kicker is, im not on any regular medication now.

Im only on day 2 of 5 sessions of ketamine, which only take an hour or two of feeling intoxicated, but then the next day my depression is just gone.

Time will tell if its lasting, but going by the research its very promising.

That is good news man. I really hope it it continues and more importantly is lasting. How much is it costing you? I checked the closest city to me and it was "out of pocket" only and out of my price range. I might have to reconsider it at some time though. Over the course of the next couple of month let us know if it helps you. Good luck!

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  • 4 weeks later...

Yes Jaiho how is the treament going? Has anyone read a post for itstrevor? I'm curious if he's still improving. If he is still improving he's the only one that I know of so far (I could be dead wrong though). The med that was helping me stopped working for some reason. I'm on Abilify (5mg) and Wellbutrin XL (300mg) and it's giving me some relief from the anhedonia but it's got to get better before I say anything anymore. LOL Maybe in 3 months I'll say something....but again, it's made the anhedonia fade a little and I"m engaged in activities now so maybe something is working...to early to tell at this point....would like to hear from itstrevor though...

Edited by james555
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Ketamine doesn't seem to bring emotions back but it lifts the depression fog nicely. My mood is good, it brings back pleasure for things, smells, music.

For emotions though the only success i've had for that is freebase NSI-189 or abstaining from porn

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I posted here a long time ago, and am coming back for a little advice on what to try next.

I'm doing a little better...my life situation is less stressful and I've made friends who I actually enjoy being around, so perhaps I'm not 100% anhedonic like I thought.

Here's my regime:

1. Decreased meds: now taking cymbalta 30 mg and lamictal at 150 mg

2. Eating a gluten free diet

3. Taking supplements:

-iodine

-selenium

-vitamin b2 (I discovered this helps with my chronic chapped lips)

-vitamin D

-omega 3 from fish oil

-St. John's wort

-I also take an over-the-counter antihistamine but that's for allergies

4. I'm working on packing healthy snacks so I don't go out and buy junk food during the work day, and cooking at home more.

So my dillemna is between adding in Berberine (wikipedia it, the stuff has a lot of possible uses one of which is for mental health) or Sam-E. What do you guys think would be most helpful for anhedonia?

Edited by anne_of_green_gables
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I posted here a long time ago, and am coming back for a little advice on what to try next.

I'm doing a little better...my life situation is less stressful and I've made friends who I actually enjoy being around, so perhaps I'm not 100% anhedonic like I thought.

Here's my regime:

1. Decreased meds: now taking cymbalta 30 mg and lamictal at 150 mg

2. Eating a gluten free diet

3. Taking supplements:

-iodine

-selenium

-vitamin b2 (I discovered this helps with my chronic chapped lips)

-vitamin D

-omega 3 from fish oil

-St. John's wort

-I also take an over-the-counter antihistamine but that's for allergies

4. I'm working on packing healthy snacks so I don't go out and buy junk food during the work day, and cooking at home more.

So my dillemna is between adding in Berberine (wikipedia it, the stuff has a lot of possible uses one of which is for mental health) or Sam-E. What do you guys think would be most helpful for anhedonia?

Haven't tried either one of those so not sure. But, another good resource to ask about this is at Crazymeds, some over there have decades of experience taking all types of meds.

Ketamine doesn't seem to bring emotions back but it lifts the depression fog nicely. My mood is good, it brings back pleasure for things, smells, music.

For emotions though the only success i've had for that is freebase NSI-189 or abstaining from porn

In my opinion, if it brings back pleasure in things it's working for you, not much out there at worked at all for me..I'd say, stick with it if you can.

Is NSI-189 is like Nootropcis? My current meds are causing high blood pressure so even though I'm getting some relief (believe it or not I am) it's causing a side-effect I'm uncomfortable with so I'm all for trying that Nootropcis. I'm not about to start trying TCA's and MAOI's at this point. But I have no idea how to obtain Nootropics. I've already searched and nothing....so that might not even be an options...***...

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  • 2 weeks later...

Over the past two weeks, I've been seeing improvements in anhedonia, emotional amnesia, brain fog, and the like by a dramatic increase in REM sleep. That's right, REM sleep, the stage of sleep, which ordinarilly occupies about 20% of an adult's time asleep, that is vilified in the pathology of depression as a scourge of rumination, anxiety, guilt, and just happening way too much. The fact is, REM sleep happens way too little in my baseline, probably about 5% on most nights. I'm doubtful I have also increased non-REM deep sleep, but hypothesize I've swapped stage N2 and N1 sleep for REM.

Antidepressant drugs, especially irreversible MAOIs, squash REM sleep. Lots of other things, like alcohol, cannibas, and many other supplements squash REM sleep as well. All of these drugs have been disasterous and inefficacious for my sleep quality and, not surprisingly, my anhedonic symptoms as well.

There seems to be little to no scientific evidence for the importance of REM sleep. Humans deprived of REM sleep don't drown themselves in a forced-swim test like rodents do - but that's probably because it's unethical to do forced-swim tests on human participants. I would wager that there is a subest of depressed people that do benefit from REM suppression, but I can say with certainty, as a person with pure anhedonic symptoms and nothing in common with depression or depressed persons beyond the vagueness of the diagnostic criteria, that I need REM sleep badly and I might just get better if I can keep up with the dreaming.

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Hello there,

This is my first post in this forum. I've suffered from anhedonia for about a year and a half now, since november 2013. I've read alot about this issue on different websites etc. and it seems indeed that the individual cases differ in a lot of ways. For example, I can remember exactly which day it was that my anhedonia manifested itself, it just showed up over night, between the 14th and 15th november 2013. I was out partying the night before, nothing out of the usual, and just woke up feeling completely empty in my head. I just guessed that I was madly hungover and didn't put much thought into it. A week passed, then a month. Still no improvement. Christmas arrived and I felt no emotional connection to it whatsoever. This is where I started accepting the fact that this emotional numbness would stick with me for the long haul. I spoke to a therapist in may 2014, about half a year after the anhedonia had showed up. She told me that I didn't have to worry about it, since it's probably a syndrome of posttraumatic stress disorder which will soon dissolve. (A close relative passed away a year before my anhedonia started).

I also wanted to ask if anyone has smoked maja and gotten anhedonic symptoms from it. Some years ago, after several occasions of smoking maja, my emotions got blunted, and I just felt completely unmotivated to do anything with my life. Just waking up was a huge challenge. This only lasted for about 4 months though, and about a year later (november 2013) my brain decided to jump back into this state of mind. I'm not sure whether my current state of numbness has anything to do with the pan smoking (neuro-transmittal damages in the brain?) or if it is rather the unconscious emotional withdrawal that probably occurred after my relative died.

What is most frustrating, for most of us I guess, is that we actually do want, and do try everything we can to get back into our normal states. Most doctors think that we're filled with anger/sadness/jealousy, but just bury it in ourselves intentionally. This is not the case. I've tried, several times over, to cry, to release some kind of suppressed emotions which I'm supposed to have. I've actually managed to cry, but there is still not enough emotion connected to it to make it feel genuine. The times when I've tried real hard to feel anything, I've actually felt a weird kind of pressure in my frontal lobe, as if my brain was fighting against whatever I was trying to do. I could physically feel the blockage of emotions in my brain, which was very unsettling.

Another thing I've thought about is the impact of this neutral state of mind in our lives. Since we do not feel anything, we never really feel urged to do anything about it. Meanwhile, our lives are passing by, friends are going in and out of our lives, everything out there keeps moving on in its normal pace, while we're stuck in this mental prison. What I'm trying to say is that even if I get fully recovered from this terrible, numb state, I can never relive the time it has consumed. I have been travelling alot, been making alot of memories which just hasn't emotionally stuck inside me, and that is another frustrating factor. I could go skydiving, skiing or anything, but in the end, the memory of it would be vague as there would be hardly any feeling attached to it to remember. Sitting in my room would give just as much pleasure.

I certainly hope that it will dissolve though, and I keep being optimistic. For you males, I can recommend totally cutting out pornography, since it messes with the brain more than you'd think. There is alot to read about it on the net. I'm also going to try taking excercise more seriously and focusing on keeping myself in shape, both mentally and physically. I hope you're all doing well, I want to urge you to fight on, because I'm sure that there is a relief for everyone. Talk to you soon!

Edited by Levander
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Hello there,

This is my first post in this forum. I've suffered from anhedonia for about a year and a half now, since november 2013. I've read alot about this issue on different websites etc. and it seems indeed that the individual cases differ in a lot of ways. For example, I can remember exactly which day it was that my anhedonia manifested itself, it just showed up over night, between the 14th and 15th november 2013. I was out partying the night before, nothing out of the usual, and just woke up feeling completely empty in my head. I just guessed that I was madly hungover and didn't put much thought into it. A week passed, then a month. Still no improvement. Christmas arrived and I felt no emotional connection to it whatsoever. This is where I started accepting the fact that this emotional numbness would stick with me for the long haul. I spoke to a therapist in may 2014, about half a year after the anhedonia had showed up. She told me that I didn't have to worry about it, since it's probably a syndrome of posttraumatic stress disorder which will soon dissolve. (A close relative passed away a year before my anhedonia started).

I also wanted to ask if anyone has smoked maja and gotten anhedonic symptoms from it. Some years ago, after several occasions of smoking maja, my emotions got blunted, and I just felt completely unmotivated to do anything with my life. Just waking up was a huge challenge. This only lasted for about 4 months though, and about a year later (november 2013) my brain decided to jump back into this state of mind. I'm not sure whether my current state of numbness has anything to do with the pan smoking (neuro-transmittal damages in the brain?) or if it is rather the unconscious emotional withdrawal that probably occurred after my relative died.

What is most frustrating, for most of us I guess, is that we actually do want, and do try everything we can to get back into our normal states. Most doctors think that we're filled with anger/sadness/jealousy, but just bury it in ourselves intentionally. This is not the case. I've tried, several times over, to cry, to release some kind of suppressed emotions which I'm supposed to have. I've actually managed to cry, but there is still not enough emotion connected to it to make it feel genuine. The times when I've tried real hard to feel anything, I've actually felt a weird kind of pressure in my frontal lobe, as if my brain was fighting against whatever I was trying to do. I could physically feel the blockage of emotions in my brain, which was very unsettling.

Another thing I've thought about is the impact of this neutral state of mind in our lives. Since we do not feel anything, we never really feel urged to do anything about it. Meanwhile, our lives are passing by, friends are going in and out of our lives, everything out there keeps moving on in its normal pace, while we're stuck in this mental prison. What I'm trying to say is that even if I get fully recovered from this terrible, numb state, I can never relive the time it has consumed. I have been travelling alot, been making alot of memories which just hasn't emotionally stuck inside me, and that is another frustrating factor. I could go skydiving, skiing or anything, but in the end, the memory of it would be vague as there would be hardly any feeling attached to it to remember. Sitting in my room would give just as much pleasure.

I certainly hope that it will dissolve though, and I keep being optimistic. For you males, I can recommend totally cutting out pornography, since it messes with the brain more than you'd think. There is alot to read about it on the net. I'm also going to try taking excercise more seriously and focusing on keeping myself in shape, both mentally and physically. I hope you're all doing well, I want to urge you to fight on, because I'm sure that there is a relief for everyone. Talk to you soon!

Thank you so much for sharing. I feel like I can relate to your story very, very much. I have been going, and still am, through very similar things as you. I am going to be starting a new antidepressant soon, hopefully it might help somewhat.

Anyways, thanks again for sharing! All the best

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  • 4 weeks later...
  • 3 weeks later...

I guess itstrevor moved on something...he's been the only one that might have gotten out of this? I am still suffering, been about 4 years now...this has definitely taken years off of my life. I'm currently  looking for a new doctor as the one I have is way too conservative and will not try something new. And I'm not going to take anymore of these generic "med solutions" any longer, I'm done with that. With or without meds I'm screwed at the moment though, this is horrible.

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  • 2 weeks later...
  • 2 weeks later...

So my dillemna is between adding in Berberine (wikipedia it, the stuff has a lot of possible uses one of which is for mental health) or Sam-E. What do you guys think would be most helpful for anhedonia?

"Other studies have shown berberine to increase noradrenaline and serotonin levels in the brain (rats) while inhibiting dopaminergic activity."  https://en.wikipedia.org/wiki/Berberine

If Berberine inhibits dopaminergic activity it might make the symptoms of anhedonia worse.

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  • 3 weeks later...

Anyone have anything that seems to help longterm? I know for me just eating healthy, avoiding foods I'm sensitive too helps and I sleep better. I regularly taking a variety of b vitamins and magnesium. Man there's been so many things I've tried that didn't help me... But I do think everyone is different and what one drug might work for someone might not work for another. 

 

I've been quite interested in the methylation cycle. I've been taking some supplements to help with that. Basically I have a gene defect (I found out through DNA testing, site is called 23andme if anyone is interested, costs 100 dollars gives you a plethora of information though) that basically makes it more difficult for my body to detoxify and repair DNA. So I've been taking methylated folate, b6, and b12. I do notice a difference if I haven't been taking it for a few days... but if I take too much it also seems to affect me negatively. Stress reduction seems to be a huge part of feeling well too. 

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No offence to anyone here but I normally feel worse after visiting the anhedonia forum

I fell into a deep depression 6 weeks ago. Given up on anhedonia, I'll probably die that way.. doctors have got me on venlafaxine after having bad suicidal thoughts. It's early days, it may be helping. The thoughts have lessened.

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