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Lioninwinter

Answers To Curing Anhedonia/numbness/apathy, No. 2

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This is a new board created solely for the discussion of topics relating to anhedonia, "zombieness," apathy, etc. The previous topic is very long, which is why this is new topic has been created. Please feel free to continue posting here, and the topic will be maintained at a maximum of ten pages simply so that it's easier to read and digest. Please feel free to continue the discussion from No. 1. here and to create your own topics within this board.

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Hello everyone,

As lioninwinter said, this is the continuation of the original thread: answer to curing anhedonia/apathy/zombieness etc... which has now been locked and has 3195 replies.

We also now have our own subforum thanks to lioninwinter. New general topics related to anhedonia should be pinned soon such as medication or recovery threads. All of this will make it much easier for everyone and especially new members to gather information about anhedonia.

Good luck everyone

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Hi everyone. I'm trying some type of product (GHRP-6) supposed to increase growth hormone.. not expecting much but someone on another site said that along with a few other peptides and mifepristone helped him feel normal again.

Still trying to find a legit site with reasonably priced mifepristone but seems like that's hard to come across.

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Hi. I had a sudden onset of impotence anhedonia, and reduced pleasure sensation over my body five years ago and its never went away. I didn't do any drugs or anything crazy. Its like I'm 1/20 less sensitive to touch. I am having MRI on the 18th of brain and pelvis. I suspect pelvis will be negative but I have to rule it out. I have whole genomic testing and am analyzing the results. If we could get more people to have whole genomic testing (6k a person), we could possibly isolate the gene or genes that are mutated and causing the condition. It may help SSRI damaged people as well as the pathway could be identified and a drug developed or applied if it already exists. Please don't give up. I won't if yall won't! Fight on brothers! Normal prolactin level, slightly low testosterone supplemented with only minor improvement.

Tried, no/little help

Requip

arimedix

Will try

Peritol carboheptadine

Helps

coffee

alcohol

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Hey folks! I think i have found the cure for anhedonia. It is as follows:

1. Selank peptide (read up and do ur research)

2. Mucuna Pruriens (read up and do ur research)

3. Melanotan 2. Yes, the barbie drug. (read up and do ur research)

4. Work out and get fit so you start feeling good about ur body.

5. Eat healthy. but don't go full ****** on the diet thing.

6. My personal experience with Apple polyphenols has given me more energy. (optional)

And ofc. Make sure that the things i have written is legal in ur country before ordering. And try to stay away from benzo's for as much as you can.

U r welcome!

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Semax is more of a nootropic, nootropic kind if u know what i mean. It gives more energy but does not have the same effect on anhedonia as selank.

If you search each of them up and do some reasearch on them both i think you will know by urself. Try looking it up on pubmed.

I can throw out a link with some info: http://www.smarternootropics.com/selank/

As for my prior symptoms. I'll put it very simple, not having the ability to feel at all. Like being traped in a loop and i thought that nothing could ever bring back the old me.

In the worst part of it all i could not even cry, feel love to those who stood me nearest. It was like my mind did not allow me to feel any thing anymore.

It's all about getting back the chemistry of the brain back in check and if you find urself in some kind of bad habbit, break it.

If someone going to try this i wish them good luck! Sry if my english is not top notch (not my native language) Deal with it ;)

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Wow I am always surprised to see new stuff out there I didnt know about, gotta do more research!

Sedank and semax sound a lot like nsi 189 which can increase bdnf and growth factor.

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I've have had access to some Sativa. It has turned the lightbulb a bit dim however focus seems to have increased as I was able to fool around in Dark Souls 2 for 1.5 week or so. Also managed to fool around with charactercreation for 20 minutes or so. Would have been impossible with all the thoughts in the cranium otherwise. I probably got ADD but I wont get that because some sad excuse for a doc put me into a hospital for psychotic people and the only drugs they give out is those lowering dopamine with the exception for abilifry (partial dopamine D2 agonism). Asking for methylphenidate = drugseeking behavior anyway. It's probably not too uncommon but Ritalin had a calming effect the time I tried. This coupled with organizationissues and proneness to leave the bed while copulating due to being bored to grab a banana in the kitchen concludes that this organism is ADDafflicted.

Selegiline is down to 2.5 EOD. Those plans of starting up a business selling mead on the internet is gone. I've thrown away the empty bottles and has joined the proletat once again. As I've pointed out before Selegiline didn't help much if anything regarding anhedonia however I was having some fantasies about the best weapon in weaponsimulator Dark Souls 2. It's not bad getting a bit lofty through increased levels of dopamine though anxiety also increased. Tried to handle it by excersising 30 minutes each day and I still into that routine however if it helps more than just during that act it's not enough. At initial 5 mg ED coupled with some nicotine and one cup of coffe I almost had panicattack regulary.

It's not even good now at 2.5mg EOD despite (or possibly because) of me doing away with nicotine. Adding benzodiazepine (which I won't get prescribed, despite no abuse, by my doc due to being sadist or something) would probably only counteract the increased levels of dopamine anyway. Opiates may help.

I've ordered and received Naltrexone however. I suppose when I am stable I might try out Low Dose Naltrexone. Would be nice if it potentiated the mu-opioid receptor but will probably at best end up with those just being slightly stimulated and possibly making the organism lazy again and it stops going to the gym. Maybe I also increase Selegiline to 2.5 ED as anxiety almost seems to be binary.

Also forgot, Selegiline has practically cured my socialphobia I've had since 1994. Never thought it had such an impact. But there's no mystery to it. Increased dopamine at wherever the "selfesteemcenter" is usually equals increased selfesteem. Could probably been helpful if I had got it around 1997 or so.

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I've have had access to some Sativa. It has turned the lightbulb a bit dim however focus seems to have increased as I was able to fool around in Dark Souls 2 for 1.5 week or so. Also managed to fool around with charactercreation for 20 minutes or so. Would have been impossible with all the thoughts in the cranium otherwise. I probably got ADD but I wont get that because some sad excuse for a doc put me into a hospital for psychotic people and the only drugs they give out is those lowering dopamine with the exception for abilifry (partial dopamine D2 agonism). Asking for methylphenidate = drugseeking behavior anyway. It's probably not too uncommon but Ritalin had a calming effect the time I tried. This coupled with organizationissues and proneness to leave the bed while copulating due to being bored to grab a banana in the kitchen concludes that this organism is ADDafflicted.

Low doses of medical Sativa and I get along much better than it's Indica cousin. There's a mild increase in curiousity and other "wanting" thoughts, a significant libido boost, and a hit-or-miss ability to slightly increase focus. On the other hand, it's tricky to only consume a low dose and too much is definitely not benefitial in any way, unless you need to eat everything in sight. I think low-doses of medical Sativa are useful as an adjunct to more useful treatment of anhedonia, but there's not much good evidence for efficacy in even the more common and intensively studied forms of depression as a primary treatment.

Edited by Dichotohmy

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Has anyone tried NAC? I've been taking it for a week with surprisingly good results. I feel like I'm waking up, and just hope it will last. Also started on MSM two days ago, and been taking TMG for about six months. Aside from my multivitamin and occasional omega 3s, that's all I'm ingesting.

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Thats cool NAC is helping, ive never tried it really but alqays heard mostly good things about it, it surely wont hurt.

I wish I could play video games like before but i just get way too bored now. I used to feel euphoria playing cool video games before and was addicted to it and I dont regret one second I spent playing. But that time is over and honestly if anhedonia was to lift suddenly, I still wouldnt play. I think I would have more important things to do than video games and I wouldnt waste my ability for pleasure on that, maybe im just older now.

I do like to play pool and chess tho for distraction, but anhedonia is a true buzz killer.

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how many of you guys play a lot of videogames?

Me. but i only started playing them more once i got depression.

When i was not depressed i rarely played games, i wanted to get out and live life. now i just want to sit in my room

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how many of you guys play a lot of videogames?

me, i have my whole life really... Kinda stopped my late teens though but started again once all this happened.

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Dont you guys get bored of video games? I dunno I cant seem to get really interested anymore no matter what the game is, maybe its just not for me anymore cuz i like other stuff.

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personally i play videogames a lot and compulsively, even if i dont get much real enjoyment out of it anymore, but because its kind of an addiction as a way to be entertained and not to think about anything... i think that this, combined with maybe pornography exposure, might contribute to the anhedonia

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Hello,

I as well have this.. anhedonia. It started at depression, now that I've been in therapy without meds for depression, i'm now left with the blank, emotionless 'feeling'. [i have tried citalopram 5mgs/1week to 10mg/3 days since it made me worse during depression, then tried the generic prozac for maybe a week and just felt too depersonalized.] So meds weren't something I wanted to continue to try.

I was really depersonalized for a long time, that did eventually improve and slowly continues to, so that's giving me some hope that being emotionless isn't forever either.

Really, this is probably a wierd question, but has anyone noticed if they -were- ticklish before the anhedonia and now aren't?

Maybe it's cause you don't actually feel the giddy feeling inside when you're tickled? I don't know >.<

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Aliixa I still can feel very tickly and always been like that even before anhedonia lol For me being tickled is neither pleasurable or painful, just slighly annoying.

Ssris will very rarely help anhedonia and most often make it worse. You are right to not take any ssris for anhedonia but it doesnt mean you should completely forget about meds.

I will start very soon a trial of nsi-189 which is a very experimental med that a member of this forum had some success with for anhedonia/lack of emotions. I would never touch a ssri for anhedonia, that is just silly, at least for me since i got anhedonia from a ssri.

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I see playing videogames as a sign of being able to enjoy oneself somewhat (I am aware of it also may be in a compulsive way but being able to sit still and at least engage in something) however it's obviously it correlates with possibly high levels of GABA and possibly Serotonin rather than being "dopamine driven". I got off of Selegiline. As I stated it got rid of Social phobia, it increased selfesteem, it increased drive, I always had energy and libido got ridiculous high at doses of 5 mg each day and with 2.5 mg EOD was probably higher than adolescense (At least with fluoxetine). The thing I coulnd't stand is not being able to be still for a minute despite supposely just having a so called "mild depression" due to to be able to "enjoy something" or sit still. I've managed to play through Metro 2033 and Metro 2034 without urn (sativa). Sadly I just cant increase escitalopram from 5 mg to 10 due to anxiety and headache and Dr Psyche I say wont prescribe benzodiazepine even for getting rid of startingup anxiety so despite having ordered 100 Etifoxine (nonbenzodiazepine anxiolytic supposely comparable with lorazepam) from the interweb I decided to return to my old workhorse Fluoxetine 20 mg. This is just day 2 and I am singing in public without thinking about it. Sure, tired as hell and I am expecting shrinking testicles, limpdick and so on. Ironically I'll probably start to get along with girls at the pub after this as SSRI usually triggers semialcoholism here likely due to SSRI lowering dopaminelevels (there's a Dr Healy site where it's written about extensively).

Everything is a struggle after these 20mg. Whereas It was almost hard to not get to the gym earlier I have to push myself. Even taking a shower is a small struggle. It's worth it afterwards however which is more than I can say of my predopaminergic state. I think reboxetine could be helpful or switching to maybe venla****sin. Last time I got on reboxetine with reboxetine I drank a lot of coffe and started to write some code and stopped when Iand ex doc decided to try out if norepinephrineRI would be enough. It didn't, everything turned into dung. Retrospectively we should have put fluoxetine back but fooled around with other combos. Another funny thing with reboxetine was me sitting and waiting 50 minutes in the laundryroom to yell at people not picking out their laundry from the machines. NRI seems to turn people into friends of good order.

For those like me that can't stand being driven in the dopamine kind of way I am quite sure you have to choose between being able to sitt still with anxiety somewhat under controll and well sort of the opposite. Consummatoric anhedonia may be something else still likely have to do with endogenic opioidsystem. Maybe that was triggered somewhat indirectly by Methylphenidate and somewhat by Bupropion earlier possibly potentiated by a long period of understimulated dopaminereceptors due to SSRIdrug.

This is nothing new though as itstrevor wrote something about it earlier like 500 threads ago though it's interesting to have tried it out in practise. However this will turn out into apathy of course and as mentioned reboxetine is probably going to be necessary,, just have to see if I need to order that myself as well.

Yeah another thing about gaming which I've shown earlier.

"

Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction."

http://www.ncbi.nlm.nih.gov/pubmed/20695685

Also this classical one. low dopamineleves are implicated in low social status in apes.

http://www.ncbi.nlm.nih.gov/pubmed/11802171

Last time I tried to quit SSRI (lexapro) I didn't quite get the same overstimulating effects as from Selegilne but rather had better response to especially music. It was like everything started to sound good which is quite worrisome. Taken to extreme it would mean someone could start to eat feces or something. Of course anxiety/depression brutally returned after a while. It was like coldturkey anyway. You know like if people forget to take their SSRI with short halflife for a while they probably suddenly start to feel better.

I wonder what a partial low dose Dopamine D2 agonist like Abilifry would do. Probably increase anxiety as well. Probably having similar effect to Buspirone (low dose) which was prosocial as I also is doing something with D2receptor. So yeah I don't think I will be able to do better than Fluoxetine and possibly reboxetine (I notice L-tyrosine is like a milder version of reboxetine) at least in the long run. I tried Sarcosin with no results for at least 3 weeks. Still got some to try out to probably no avail. I also have some piracetam lefts which I found didn't do much either but messing with dopamine seems wrong despite everything of course pointing to it being low. Tiny doses of Fluoxetine <5 mg or something was definitely activating and if it wasn't for anxiety necessating Serotonin->GABA I think either that or Agomelatine could be beneficial. Also mentioned before, Agomelatine is the only drug I've seen with at least one study posing it helps for anhedonia (though not specified what kind, still think it's rather about depression lifting without having those serotinergic effects) which also points to HT-2c antagonism. But it's also a drug touted for having no sexual sideeffect where it caused a mild version of limpdick here.

Edited by General_Failure

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Personally i lost faith in SSRIs/SNRIs for our condition. I agree Fluoxetine is useful because its an atypical SSRI unlike the rest. It increases DE/NE in the prefrontal cortex, along with its not hugely selective SE reuptake inhibition.

It still blunts emotions, especially in high doses. Though it increases color and connection to the world again.
The tiredness sucks. I tried multiple ways to offset that via modafinil but that did not work well.

So i've turned to a reversible MAOI, along with potent neurogenesis drug called NSI-189 if you saw my thread. The cloud isnt as lifted as cleanly as Fluoxetine, but, emotions are returning and its still early days.

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I tried gym exercises for months and it's not working for me. You only get fake happiness for few hours at most after playing due to endrophins (and still it don't feel like the natural happiness and enjoyment). I want to know the relation between exercises and depression/anhedonia because I do almost daily exercises so its a bad thing or good?

edit: You can "faky enjoy" things in the endrophin hours but still it feels fake and not a real enjoyment. Its like your brain is accepting anything just because endrophins are released.

Edited by MegaBlaze

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