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Agomelatine (Valdoxin, Melitor, Thymanax) Posts

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Hi Sinine,

Thanks for your post, nice to hear from someone for whom it's worked. I've stopped Valdoxan (after 4 weeks), I wasn't getting any better on it. I'm thinking I'll try Sertraline (zoloft) next.

Clip

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Just starting Valdoxan as used in the priory clinic, have been on cipralex for 3 years but as with all ssri meds the weight gain was just to much, and it increased my blood pressure , as I work out a lot this was a shock!! So I went to see my physiatrist at the priory and he said to try this new med Valdoxan 25 mg , so lets see what happens, it's not ment to increase weight or have the usual side affects of ssri drugs.

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Hi Chloe and Gaze,

I've been searching this forum for answers. Sadly, I don't read any major improvements with Valdoxan.

It's my 3rd week on Valdoxan. I can't emphasise enough how hard it has been switching from my previous anti-depressant (cipralex) to this one. Emotionally it's been absolute hell. I was in a very deep depression for the first 2 weeks and couldn't stop crying. As this is the 3rd week, I am "out" of that deep depression state, but I am not happy. Not at all. I have got no motivation for the day and I feel that I am only breathing, and not living. Im very irretable, snap really quickly, simple things can really irretate and annoy the crap out of me, I'm not aggressive though. The thing that really bothers me is that I'm not feeling happy, I feel that I'm not living. Things that made me smile just doesn't do it for me anymore.

Some days I feel I can just cry, but many times are unable to. (not because I'm not allowed). Or that I really need to see a therapist. But don't have the strength.

At this stage I hope it gets better. I really do. Living like this is absolute hell, and there are so many thing within life to enjoy. But mentally, I just don't enjoy it.

I would very much like to know your experience as you've been longer on the drug than me. Hope to hear from both of you soon.

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Hey Kevvie,

Well I have hit my 4th week and I just don't feel like its working as well as a previous medication I was on which was lexapro it helped a lot more with my anxiety which is my major problem.

I've been having panic attacks which are debilitating and have been sick most of the time. I do feel like I am better than I was when I first started but haven't noticed any more improvements.

I too have days where I just feel like crying all day long and my mum seems to think I am always in a cranky mood (although I don't notice that lol).

I am not sure whether to continue the medication for 6 weeks or pack it in because I'm not sure how long I can handle it my whole life is consumed with anxiety

Hope to hear from you soon :)

Chloe

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Hi, I have mild depression and have been put on valdoxan for 6 months. Has anyone had any success on this? I don't want to take mess for the rest of my life... Looking for something that will help me get back to normal - I lack feelings, tired a lot, don't feel like doing anything, memory loss, stay away from friends sort of thing... Will 6 m on valdoxan cure this? Totally new. Cipralex for a year helped me a good many years ago. Thanks x

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In general if you've had multiple episodes of depression there's a good chance you will need to be on meds permanently, or at least keep starting and stopping them which can be a pain as the same med doesn't always work a second time. There's at least one person on here who has had success with Valdoxan who can chime in though.

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Hi there,

I started Valdoxan 24 days ago. I have had depression for almost 10 years with more than a year of psychotherapy and only 6 months with antidepressants. I tried 5 antidepressants in 6 months, from SSRI to SNRI. The last one was Effexor, which made me decide to leave the treatment and the psychiatrist since, along the 6 months of medical treatment, I felt worse than when I had to struggle only with depression. Since I began the medical treatment, I began to suffer of anxiety, which had never been an issue for me, but the worst was arrived when I took Effexor. Despite of that all the psychiatrists I have asked have answered me that the withdrawal effects are time limited, I have to say that anxiety is an effect of those antidepressants in me, since I was never an anxious person before starting the medical treatment, even during the 5 years I faced depression without taking any drug.

The last week I felt very anxious again and I wonder if Valdoxan has something to do (anyway it happens to me often since 2008 when I was taking antidepressants)... and if I should expect to feel anxious often with this treatment. Where can I found reliable information about secondary effects and how much time they are supposed to last? I ask for this since I think that it is a right of the patient to know which are the undesirable effects of any treatments in short, mean and long term. Often, the information only refers to the short term effects. In this order of ideas I want to ask: Is there any foundation or movement which lead any campaign to force the labs to publish information about the real long of the secondary effects of their antidepressants?

I think that I will continue taking Valdoxan since this is the first antidepressant I feel is working on what it has to do. Anyway, I want to know all the possible effects I would face in the future (the only I know is the one related to liver issues).

Thanks for your answers!

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I have started Valdoxan around 24 days ago. I took SSRI and SNRI for 6 months without any success more than 4 years ago. I left psychiatrist and medication as I felt worse and worse because of the secondary effects than only with depression.

Since I got worse of depression recently I decided to go back to the psychiatrist and this time I have been put on Valdoxan. I have had no secondary effects and I feel that this antidepressant is working for me by the first time. As Velthir says, my psychiatrist has told me and I have read too that any antidepressant has to be kept by 6 months after symptoms remit. And people with long and/or several depressive episodes (my case) has to keep medication for 1 to 2 years, or permanently.

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I've been on Valdoxan for a week.

Also very unsure of the side affects and the success.

I have mild depression - typical exhaustion and don't feel like anything...

From what I know though, these meds take a while to work / to kick in. Sometimes up to 2 months before you see any improvement.

Apparently Valdoxan works faster though and I should feel better in as much as 2 weeks.

I wonder though if we don't all get a little too paranoid by searching the net for answers - reading about the side affects - searching for the quick fix.

I realise we are desperate, but maybe we should chill out and give the meds a decent amount of time to work without over analysing every thought and feeling?

Just a thought.

Basically all I want is to hear from someone who has been on this med for 6m - 1y and how they function now???

Thanks,

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Hi everyone,

I'm brand new to this site...

Sigh ...where to start...

Well I have been given valdoxan for anxiety which is so horrible I feel horrible in my head, jitters, if I nap I wake up and have terrible anxiety that make me almost vomit, heart beat strange etc etc. I have started to get a bit of the blues of late as nothing has gotten rid of it.

My anxiety steams from PTSD which I have sorted with weekly therapy.....soooo

I have built the courage to fill the script and will start valdoxan tonight. I'm am sooo nervous I had a bad reaction of SSRI Zoloft 4 years ago when I lost my parents. Adding that it did work and got off it 9 months later with no anxiety or anything for year until my PTSD from a work event.

That's a little back ground of me...I guess my point is that I hope valdoxan won't give me mania (lie Zoloft) or jitters of the wired feeling. I really want it to work.

Has anyone got anything positive with anxiety or depression with the use if valdoxan? I would love to hear good news about the drug rather than a heap of bad.

I'd prefer only people on valdoxan ONLY.

Thanks peeps :-))

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Hi all,

I'm looking for answer as we all are...

Started Valdoxan (Agomelatine) 10 days ago. I have a lot of sleep problems and just moved on a busy streetside bedroom :( So until I move out I need to survive somehow...I was one year on mirtazapine and would sleep great on weekends but during working days I'd wake up at 6 am many times. I really want to change my job but don't know to what. I'm 29 yo.

I've changed projects, my new project is not stressfull at all but my sleep is still light and if I hear any noise before falling asleep I have a hard time falling asleep. My neurologist thinks I'm depressed. The psychologist said that my dep was secondary to insomnia..

4 days on 12,5mg, -> good mood but extremely tired because couldn't sleep, sleep was fragmented, had difficulty falling asleep and would wake up early in the morning. around 4 hours sleep per night!

Increased to 25mg -> first day a good sleep, although i woke up twice. then it started detiorating. Today I woke up at 3.30 am.... Had to take clonazepam 0.25mg to fall asleep again. but even this small dose makes my sleep less restful and makes me feel like crap next day.

Question is:

- Is it too early to judge this drug?

- Should I increase to 50mg now or wait one week?

Thanks a lot!

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I began to take Valdoxan 25mg as Rx'd by my psychiatrist for depression and anxiety around 10 months ago.

It has worked well in stabilising my feelings of anxiety, depression and general feelings of "I wish i didn't exist".

But I did notice that I became very preoccupied with sexual thoughts and pornography, including things of a sexual nature I hadn't been interested in before - much more than I have ever been used to - and this increased the frequency and urgency of my *************. Up until then I had quite a normal sex drive and didn't feel an 'urgency' for sexual contact that I then began to experience.

I mentioned it to my psychiatrist if this could be caused by Valdoxan - he just chuckled and said 'no'.

I have discovered that I am not the only person to experience this 'side-effect'

Has anyone also experienced this with Valdoxan?

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Hi guys anyone heard of this?, I dislike starting new medication i find it painful, and thoughts are like OCD on every side effects it's draining. I tried one dose got Insomnia and was like I'm done, I keep hoping that the Dep may lift itself and go away in time, since Anxiety seems to be my Major issue. The Doc wants me to keep going not stop at 1 tablet, I givein to easily i think when will i get a rough idea......thanks.

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Hi PPB,

One dose of any antidepressant medication is not going to be helpful and it's not going to give you any kind of indication of whether its going to be the right med for you or not. You have to give the med some time to give it a chance to work.

I have taken Valdoxan for a few years and I find it helpful in treating my depression. Let me know if you have any specific questions about Valdoxan and I'll try my best to answer them for you.

Best wishes,

Sare :-)

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Honestly you need to give it 4-6 weeks before quitting, as with every other antidepressant. You might even find the insomnia was just because of worrying about it so much, since Valdoxan often helps improve sleep.

Good luck, it's a good drug for a lot of people and doesn't normally result in bad side effects.

Edited by Velthir

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I just wanted to share my experience with Valdoxan. This was one of the threads I read before I started.


Summary: I can't believe how great an effect it has! I am so happy and surprised with how well it is working. :smile:


I had actually sworn to never try antidepressants again - when I had major depression previously I tried escitalopram (did nothing), Effexor (gave me crazy anxiety, hour-long yawning fits, dizziness, sexual side effects, no noticeable benefits for months), and Avanza mirtazipine (made me gain weight, sexual side effects, dizziness, no noticeable benefits for months). I gave up on antidepressants and recovered very slowly through the removal of stressors from my life, better self-awareness, time and a lot of patience and looking after myself.


Although I now no longer consider myself as having depression, I regularly feel it creeping back for no apparent reason (real difficulty in waking up in the morning, foggy head, impaired spatial awareness etc.). I was also feeling very wound up / anxious due to feeling on the edge of depression. So my doctor convinced me to try Valdoxan (agomelatine) based on the fact it was different from all the others. I was sceptical but thought I'd give it a shot.


And wow! Nothing much on the first or second days, but I felt GREAT by the third! I know this was not placebo effect as I would hardly have been able to wake up normally, but this day I felt like a cheerful, energetic morning person (something I haven't felt any morning for the last 2 years now), I was noticeable more social, relaxed etc. I even felt buzzed during the middle of the day, like I was super alert - definitely not a 'normal' feeling. This extremely stimulated effect lessened the next day and has not reoccured since then, but suffice to say it is still stimulating enough for me to feel like a normal person again, every day. If I am tired, I am just tired - not a zombie. I feel capable and in control of things again. I am more social and more relaxed. I can only put it down to the fact my sleep wasn't 'good' before, or I needed more dopamine-receptor-stuff, and the Valdoxan is what has changed it radically for the better.


The only side effects I have had are disrupted sleep the first 2 nights; a very mild headache everyday for the first 2.5 weeks; and possibly being more emotional than normal (i.e. getting a little more upset than normal). Definitely no sexual side effects (I am female). I have an inflammed stomach lining already, but Valdoxan didn't make it any worse at all (which surprised me, based on the amount of people complaining about stomach pain while on it). I haven't got my liver function test results back but I've no reason to think that that will be a problem.


I hope that this post encourages someone else to give Valdoxan a shot. Obviously it works differently for everyone, but I can certainly vouch for the fact it can be very effective.


P.S I have also been taking L-tyrosine every morning too. Alone, it only has a mildly stimulating effect for me (if anything). But I figure, the more dopamine available to my brain, the better, right? :smile:


Good luck to those trying it out.

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Hi all

I'm new on here so hello! Is anyone taking Valdoxan? I was on escitalopram for about 4 years and was perfectly fine. At a review with psyc she wanted to change me to this new wonder drug valdoxan. I felt fine for about 2 weeks and then it was like someone flipped a switch. I've become less tolerant to everything, i feel quite agressive at times, can't be bothered to do anything, am tearful and feel "depressed" which i haven't felt before.

I went back and said i wanted to go back onto excitalopram. She said to give Valdoxan a few more months and up the dose from 25mg to 50mg. I feel like i might be being used as a guniea pig for this new drug and have made my own decision to go back onto excitalopram so am doing this myself.

Has anyone else any experiences with valdoxan?

clar123

I've tried lots of drugs to get the right one. I am not a doctor so I suggest you follow the doctors advice and give it a try. The unfortunate thing is that you may be a bit unsettled during the initial treatment. I can only think there must have been a valid reason for your doctor to try the new drug. Try asking point blank, why change? Is she getting paid by the drug company? Don't forget to be respectful with your doctor.... if you can. Let us know what happens. Take Care!

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Hi everyone, forgive me if I write something wrong, my mother tongue is not English. I have been taking Valdoxan for the past 2 months, first 25 mg, then 50 mg. Plus I have been taking Xanax for about half a year now (0,5 mg 3 times a day). My major problem is anxiety. I did not really feel side effects at first, but now I am anxious all the time, my chest aches, I feel really low. The strange thing is that my really bad headaches ceased, but now (at times when I used to have the headaches) my pulse really gets quick (although I cannot find this as a side effect in the patient information leaflet). Can anyone please advise? I have always been and still am very frightened of antidepressants and I do not really think I could continue with a new one.

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Hi there, have just been prescribed this instead of proxac. Couldn't believe it cost €70 instead of €20 for Prozac. Does anyone know if the generic is available in Ireland yet? Would love to hear other peoples experience on it. I have taken a months supply now and my emotions feel less dulled down and am starting to get contentment from the simple things in life. Will see if it lasts :-)

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As far as I'm aware it's not available as a legitimate generic anywhere, it's not available in the UK anyway and we normally jump on generics. Most drugs have 20-25 year patent protection/exclusivity in the EU. Used to be 20-25 in the US too but Obama shortened that to 12 recently. Not sure if the EU will follow suit. Either way I wouldn't expect a generic for a good few years yet (2026 maybe, can't figure out exactly when agomelatine was first patentented but there were lots around then).

Edited by Velthir

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I was on Valdoxan for a year. Initially, I had nightmares and kept waking up every 1-2 hrs overnight however this eventually settled and I just had vivid dreams (this seemed to coincide with increasing my dosage from 25mg to 50mg). Within the first week I felt happier and less anxious and I thought I had FINALLY found THE miracle drug. However, over the next few months I started to experience migraines regularly and didn't have 1 day where I was headache free. My liver enzymes went up and I felt very fatigued - I slept half the day away. I reduced from 50mg to 25mg but the migraines persisted so I have now discontinued the drug. This is the first drug (of many!) where I actually felt some positive changes to my mood and anxiety but due to the side effects I had to stop. The last few weeks since coming off have been awful :( My mood is low and i'm extremely irritable.

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Hello all!!!!

I hope everyone is doing at least ok...

Mental health issues are hell on earth.

Much love to everyone suffering *hugs*

I just have a question re: Valdoxan (agomelatine)

I have been on so very many different anti depressants, I mean almost the lot of them, seriously.

Been on Pristiq 100mg and Lamictal 100mg twice a day for years now.

I think every now and then my body needs to be shaken up and things changed because what may have been effective to begin with loses any positive effects after a while.

I'd never even heard of Valdoxan before, but my Dr suggested this to me yesterday as I'm just hitting rock bottom again and something has to happen because all other avenues, i.e. talking until my throat closes up is not helping right now.

I've been on the decline for maybe a year now, slowly.

I've read this med is at least as effective as Prozac, Pristiq etc, and with no worse side effects, but I would be so incredibly grateful if anyone has any personal experience with it.

We all know what a leap of faith it is to go ahead and change meds, so before I do this, I would be so thankful for any input and feedback.

Thanks so very much in advance.

Kristi.

xox

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It's worth searching for Valdoxan on the forum if you haven't already. I'm not sure how many people taking it are active at the moment, but there are quite a few older threads about it with opinions.

I believe I've seen a few people who have had positive results on here.

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