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Found 5 results

  1. This is a new board created solely for the discussion of topics relating to anhedonia, "zombieness," apathy, etc. The previous topic is very long, which is why this is new topic has been created. Please feel free to continue posting here, and the topic will be maintained at a maximum of ten pages simply so that it's easier to read and digest. Please feel free to continue the discussion from No. 1. here and to create your own topics within this board.
  2. I've struggled with MDD and anhedonia for the past 6+ years. I am experiencing brain inflammation and a dysregulation in neuronal signaling due to chronic stress. Despite the fact that there are a host of studies that implicate glutamate (not serotonin or dopamine) in the pathophysiology of depression: [link removed] this type of depression is largely ignored by medicine. This youtube video does an excellent job of breaking this all down: [link removed] [link removed] This glutamatergic hyperactivity causes neuronal degeneration, compromising how glutamatergic cells excite the regions of your brain involved in emotion, reward, and pleasure: Hence, the emotional blunting, lack of energy, disinterest, amotivation, etc. I've read many studies that suggested NMDA (glutamate) receptor antagonists like ketamine, memantine, and MK-801 are highly effective in reversing the symptoms of depression. To test this theory, I bought an over the counter NMDA receptor antagonist, Agmatine. About an hour after taking it, I noticed a lift in my energy, mood, and mental clarity that no prescription drug (Wellbutrin, Remeron, Lexapro, etc) had given me. I had no response to these prescription drugs because they were all targeting the wrong mechanism. I now understand that my brain lacks the ingredients necessary to heal itself from chronic inflammation. You can read more about the effects of inflammation-induced depression here: [link removed] . Now, after doing some research into what molecules work best, I've developed a stack of supplements that are meant to eradicate this type of depression on a multimodal level: DHA-500 (500 mg, 2X per day): An omega-3 fatty acid that reverses inflammation and enhances neuronal communication. Acetyl L-Carnitine (1000 mg): An antioxidant that helps enhance cognition, reduce inflammation and elevates mood. Activated B-Complex (1 tablet) Vitamin complex that provides a sustained boost in mental and cellular energy. Agmatine (500 mg): Molecule that reverses glutamate-induced excitotoxicity. I haven't tried them all at once yet, but I'm too excited to wait until I do to share this. I know the title is a bit sensationalist because I haven't actually figured out if this will treat anhedonia, but my goal is to raise awareness of this mechanism that I feel is a very important piece of the puzzle. Modern treatment is heavily based on the monoamine hypothesis of depression, which although significant, is not all-encompassing. Feel free to share your experiences with these supplements and contact me if you have any questions and concerns. Best of luck.
  3. Would you please take our survey? We need more people to participate becasue a very relevant party has already taken an interest in its outcome. This is a glorious opportunity which we can not afford to waste and the data is already very interesting. We hope it will change psychiatry's attitude on medication induced anhedonia. We also want to make it clear that the current crop of meds are not fit for purpose in treating this illness. So however you got anhedonia/emotional numbing, please participate and help the community. We need as many of you as possible. So share it with every anhedonic across the land. Thanks https://docs.google.com/forms/d/1KQPXnrDeaoRPg9hsX_jsty7C6_KaOSC82MKyhKPUbWc/edit?fbclid=IwAR08Dx7rh8-N2L0oypUVTjsB1KiASw4KsygTIVchDKYAW14s6dZAYZJ6WpA
  4. A couple of weeks ago I went through an extreme period of anxiety and depression after a girlfriend broke up with me who I truly cared about. I have been depressed before and had much of my usual warning signs such as loss of appetite, trouble sleeping, dry mouth, racing thoughts ect. Then suddenly I felt the pain I was feeling begin to ease, which at first was a relief. But then I realized I couldnt feel much of anything, nor could I get any pleasure at all from usual activies I enjoy, even sex. You see right now I dont feel sad, angry, happy, I cant feel anything! My whole body just feels limp as I would say and I cant feel motivation. Im really scared my feelings and motivation are never going to come back, this is truly a frighteing experience, I want to feel love and compassion again so badly , but I can only muster the energy to get out of bed. Im afraid I have casued damage to my brain and will never be able to feel again. My sex drive is also zero which is also causing me concern. This is not medication induced, I have been on lexapro while this happened and had felt emotions and motivaton while on the meds. Has anyone had an experience like this before? I'm really lookiing for some positive support and maybe some tips for getting though this truly difficult period in my life. I have a wonderful pdoc who switched me over to effexor 75mg, but I have not felt much effect yet, Im thinking of asking him about wellbutrin. Again any support and personal stories of recovery from a similar place would be greatly appreciated! Love, Never Alone
  5. Okay, I'm am physicly healthy 20 year old male who never had bouts with depression/anhedonia before. However, I have always been considered a oversensitive person. About 2 months ago I was I was taking a 60 mg every day (for 2 weeks) of prednisone, along with an antibiotic to treat a spreading rash. During this time I was EXTREAMLY stressed about a girl whom I loved (really my first true love) who wanted nothing to do with me. One day I tried talking to another girl to get my mind off of the girl I loved and EVERYTHING STOPPED. As crazy as it sound I stopped having ANY emotion. No love, happieness, sadness, stress, nervoussness. Simply nothing. I must say that during the time I was stressed and on medication I did drink a little alcohol and smoke an illegal substance (stupid I know, but I was stressed at the time. However I am not a substance abuser). Over time, through exercise and trying to keep up with school and social life even though i had no interest I was SLOWLY getting my joy back. But then, stupid me decided to go out and party/ drink one night only. I FELL into a deep, deep hole of depression after this. I could feel sadness but still no feelings of stress, anger, happieness/joy. Just sadness. I planned out my suicide because of what happend to me. The worst part is knowing that I have such amazing family and friends around me and who love me and I can't love them back. I feel nothing but worthlessness in my life. I am screaming for help to get back to the old me. I just want to know what happend. I know I used to drink alcohol and smoke but that was only occasionaly. Im not abusing anymore substances. I just want to recover. I havent talked to any psychitrists yet but im not sure how well they can help. I am having trouble sleeping now also. I started taking SAM-e because I was told it can help bring back emotions, but its not really helping. WHAT HAPPEND TO ME ANYONE? WILL I STAY LIKE THIS FOREVER!? I JUST WANT MY LIFE BACK. I'M TRYING TO KEEP UP WITH IT BUT MY MIND IS SIMPLY NOT LETTING ME ANYMORE. I'M DEAD INSIDE.
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