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  1. FDA approves first generic Abilify to treat mental illnesses For Immediate Release April 28, 2015 The U.S. Food and Drug Administration today approved the first generic versions of Abilify (aripiprazole). Generic aripiprazole is an atypical antipsychotic drug approved to treat schizophrenia and bipolar disorder. Alembic Pharmaceuticals Ltd., Hetero Labs Ltd., Teva Pharmaceuticals and Torrent Pharmaceuticals Ltd. have received FDA approval to market generic aripiprazole in multiple strengths and dosage forms. “Having access to treatments is important for patients with long-term health conditions,” said John Peters, M.D., acting director of the Office of Generic Drugs in the FDA’s Center for Drug Evaluation and Research. “Health care professionals and consumers can be assured that FDA-approved generic drugs have met the same rigorous standards as the brand-name drug.” Schizophrenia is a chronic, severe and disabling brain disorder. About one percent of Americans have this illness. Typically, symptoms are first seen in adults younger than 30 years of age. Symptoms of schizophrenia include hearing voices, believing other people are reading their minds or controlling thoughts and being suspicious or withdrawn. Bipolar disorder, also known as manic-depressive illness, is another brain disorder that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. The symptoms of bipolar disorder include alternating periods of depression and high or irritable mood, increased activity and restlessness, racing thoughts, talking fast, impulsive behavior and a decreased need for sleep. All atypical antipsychotics contain a Boxed Warning alerting health care professionals about an increased risk of death associated with the off-label use of these drugs to treat behavioral problems in older people with dementia-related psychosis. No drug in this class is approved to treat patients with dementia-related psychosis. Aripiprazole’s Boxed Warning also warns about an increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants. Patients should be monitored for worsening and emergence of suicidal thoughts and behaviors. Aripiprazole must be dispensed with a patient Medication Guide that describes important information about the drug’s uses and risks. In the clinical trials for Abilify, the most common side effects reported by adults taking Abilify were nausea, vomiting, constipation, headache, dizziness, uncontrollable limb and body movements (akathisia), anxiety, insomnia, and restlessness. Generic prescription drugs approved by the FDA have the same high quality and strength as brand-name drugs. Generic prescription drug manufacturing and packaging sites must pass the same quality standards as those of brand-name drugs. The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.
  2. Hi, I'm taking 20mg of Cipralex and I'm not sure if I'm still experiencing symptoms of depression. My doctor told me to add Abilify within a week if I don't feel better. I haven't done this yet. I feel like I'm experiencing side affects from Cipralex. I'm tired all the time. Even though I feel better relatively I don't feel that motivated to do things. However, life feels 'normal' now and I'm wondering if it's the drug, a lingering depression or just my personality that's keeping me from being more active. I want to take Abilify as an easy solution. But I don't want to take it if I don't actually need to and it's not going to make a difference. I'm also scared that there will be other side-effects. Anyway I really don't know what to do.
  3. Hi, do you know if these two can be taken together? Abilify is metabolized by CYP 2D6, while Wellbutrin inhibits that enzyme. Thanks.
  4. Brief history: though I thought it was your run-of-the-mill MDD, I now have a doctor who is super on-point who has brought me around to his way of thinking, which is that I'm on the bipolar spectrum somewhere. I've tried SSRI's in the past. Looking back with what I know now, I was having a hypomanic reaction on Effexor years ago, and have always had problems like overspending and speeding periodically. My hypomania just tends more frequently to be of the anxious, irritable, dysphoric type. So I'm realizing that I have always been bipolar, and that I'm lucky I didn't have worse reactions to all the depression meds I've tried in the past. In January, I was at my wit's end and my doctor put me on Abilify 2mg to augment bupropion xl 300mg and citalopram 20mg. After a week, I titrated bupropion down to 150mg, then to nothing. We added mirtazapine for insomnia and increased Abilify to 5mg. Soon after, I started having issues with overspending, compulsive and intrusive thoughts, ultra-high anxiety level... and the next thing I know, I'm at my pdoc's office being told that I'm bipolar. He says I'm "a little bipolar" and explains that he means I may be type ii or sub-clinical bipolar (that is bipolar disorder - NOS). So after hearing all of that, I've had to quit citalopram and mirtazapine, and was given an emergency prescription for Zyprexa. This, he informed me, was to prevent my needing hospitalization because I was having serious suicidal ideation and anger control problems. He told me the best evidence for controlling acute dysphoric (hypo)mania was Depakote and Zyprexa in combination. No doubt in his mind, I've never seen a doctor more positive about something. So I said yes to both. Now I see why. Zyprexa had me feeling calmer within hours of taking it. Depakote, after 4 days, has made me dizzy and lightheaded but other than that, no complaints. He explained that both of these will be short term meds for me, until I'm more stable. He wants to keep me at 10mg of Abilify alone for a week, and then he said he's leaning towards adding Trileptal before going back to the route of antidepressants. That brings me to a whole world of questions.... Abilify 10mg and Trileptal doesn't sound too bad, I'm not concerned about that. But what I am cocncerned about are the depressive symptoms, anxiety, and attention deficit. Abilify already makes me Abili-dazed, as I've come to call it. Depakote is just dizzy, and I expect Trileptal to be the same. But I am in a more or less unwavering, desperate pit of depression at all times, and I don't think Abilify 10mg + Trileptal is going to fix that! And now I'm spooked off going on another SSRI, because I don't want to be the panicky, enraged person I become in those hypomanic episodes. So, since we want to keep SSRI's and most other AD's out of the picture for a while, what do I do about depression? I suggested Lamictal, the doctor said I need a heavy-hitter, so he wants Trileptal instead of Lamictal, at least at first. I found some interesting articles on pubmed about modafinil/armodafinil (Provigil/Nuvigil) for bipolar ii and depressive symptoms. I do have ADHD-I, and was taking Adderall 15mg bid before...and when I took Adderall, I was very high functioning and successful! I've been out of work on disability for over a month now dealing with the rapid med changes, and the idea that Nuvigil might get me going again is so very appealing. Has anyone tried Abilify in combination with Trileptal? Your results? Has anyone tried modafinil/armodafinil (Provigil/Nuvigil) to help with the cognitive side effects of your meds? Even better, to help with comorbid ADHD-I?
  5. Hi everyone, This is my first post on these forums. I am a 24 year old female in the USA. Brief history: started suffering depression at age 14, started on AD's at 18. First one I tried was citalopram, which worked well but had bad sexual dysfunction (anorgasmia). I also took lorazepam for anxiety and insomnia at that time. After that, I tried trazodone for insomnia, to no avail. Switched to venlafaxine xr, but got brain zaps and jitters that prompted me to discontinue. Took Lunesta for a bit, but could not tolerate the disgusting metallic taste that was in my mouth 24/7. Finally got to a partial remission on bupropion, added the citalopram back in, and was mostly okay. All of my treatment up until this point, where I had comfortably settled into my bupropion/citalopram combo, was at the university I attended, where I also had access to free congitive-behavioral therapy. A couple years back, my doctor, a relic of the early 1960's (he was about 90 years old) started augmenting my bupropion/citalopram with amphetamine. My work ethic and attendance were much better, and I had reverted back to lorazepam for sleep. Since that cocktail, I had to switch doctors (3 times after my elderly doctor retired) and the current doctor reluctantly accepted that this cocktail worked for me, but expressed his reservations. He thinks I have some characteristics of bipolar II or bipolar NOS, because I can have periods of intense agitation that he believes may be a type of hypomania or mixed state. I don't necessarily agree with this, but I understand why he might think that. I personally feel that my depression is 100% unipolar. Where I started to go downhill is when I developed a tolerance to the lorazepam. I went from being able to sleep blissfully on a mere 0.5mg, to needing 3 or 4mg to even feel it, which obviously resulted in considerable next day sedation. So I was swapped over to zolpidem, which got me sleeping, but gave me vicious headaches that sometimes prevented me from working. Next up was zaleplon. One 10mg capsule would give me a fleeting, tiny window to get to sleep, and if I missed it, I had to take another. I also started to have nocturnal awakenings and was getting very light, uncomfortable, non-restorative sleep. This lack of sleep resulted in skyrocketing anxiety, and I completely isolated myself and was unable to work this week. Today, I had an appointment with my pdoc, and he acted like his initial suspicions had been completely validated, asserting that my insomnia was undoubtedly caused by the amphetamine and bupropion. (A fair point, but I did have insomnia before taking either of them...) He said that the best thing for me would be to discontinue EVERYTHING, detox my body, and then start over with a fresh course of medications. This suggestion sent me into a full-blown panic. I told him that I was afraid I would want to harm myself if I were not taking any antidepressants. He said I could come off them one at a time. At that point, he was agitated, and threw a laundry list of augmentation options at me (doxepin, lamotrigine, amongst others). I shut down. I told him to just do what he thought was best, and I would comply. He offered Abilify and gave me a sample pack. I took the first dose immediately after the appointment. I've spent the rest of the day doing my homework, and trying to figure out a plan of attack here. After finding that I could get the free trial/copay card from the manufacturer, I'm okay with taking an on-patent drug. So far, I feel a little dazed and groggy, and I have some nasal congestion, but I understand these will likely go away after the first week. I'm tapering off the amphetamine, which I'm not scared about, I would skip days all the time (in a vain attempt to get better sleep). Next up is to come off the bupropion. Question 1: That would leave me with Abilify and citalopram. Does anyone have any experience with that combination? Can I reliably refer to the clinical trials where Abilify was used to augment Lexapro, or has anyone noticed a difference? Question 2: With that combination, given their pharmacological properties, I'm imagining I will still have issues with insomnia. I hadn't considered doxepin before, but from what I've read, it sounds like it would mix in well with the Abilify/citalopram combination. Doxepin sounds like the perfect solution to add a wider range of effect on the depression and solve my insomnia problem. Yes/No? Thoughts? Question 3: In the next few weeks, as I titrate down my dosage of the bupropion, what can I expect as far as withdrawal? I'm coming down from Wellbutrin XL 300mg 1 q.am., will likely go down to XL 150mg 1q.am. then to SR 50mg b.i.d before stopping altogether. Any experiences? P.S. What time of day are you supposed to take the Abilify? I've read both morning and night. I'm thinking evening because of how groggy I feel on this first day, but I realize that might change.
  6. I am on Abilify and it has caused me to have Diabetes, type 2. Has this happened to anyone else? My psychiatrist knew it might cause diabetes but didn't mention it to me until I had already gotten it. This has caused more complications than I want right now.
  7. Hi all. I am new here. Stared a very low dose of Abilify. Initially, only 2mgs, but really started to gain weight and feel bloated. Cut back to 1 mg, but now I am experiencing Akathisia, or acathisia, (is a syndrome characterized by unpleasant sensations of inner restlessness that manifests itself with an inability to sit still or remain motionless). Anyone else have trouble with this? It's driving me crazy. I feel like I have ADD. I can't sit still to use the computer for very long, have a meal, read a book. I have to keep getting up. I'd love to hear what others have experienced and what solutions your doctors recommended. Thanks!
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