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  1. PLEASE KEEP IN MIND THAT I'M TALKING ABOUT MYSELF. I'M NOT A DOCTOR AND THIS IS NOT TO BE CONSIDERED MEDICAL ADVICE. From the threads about Remeron I've read, I may have everyone beat in the length of time I've been on it. I was first prescribed it at 25 years ago and have been on it ever since. I started at 15mg and ended up at 45mg. The irony is, that I never really felt it helped me, but I just kept doing what my doctors advised. It was Wellbutrin that actually pulled me out of a severe, major depression back in the 90s. About 5 years ago, I decided to try to get off of Remeron. I had successfully tapered off of other drugs and wanted very much to get off of Remeron. I had tapered off of tranquilizers before that, and discovered that Remeron was causing me a bad case of restless legs which the tranquilizers had masked. Since I was on such a high dose of Remeron at the time, I started taking it in the morning. I knew that at 45mg it was not helping me sleep. Taking it in the morning worked, because I would be up and moving around and the restless legs weren't a problem. I had read some real horror stories about coming off of Remeron, and after so many years, I decided to do it VERY slowly. The traditional advice for tapering psychotropic drugs is NO MORE than 10% at a time - and no more often than every 2 weeks. I started at less than 4% a month. I'm skilled at pill splitting, so I cut the 45mg pill into 4ths and one day a week I would only take 33.75mg. Once a month, I would lower my dose, always keeping below or around a 5% drop. Eventually I got to a 30mg pill which I also began to split into 4 quarters. I didn't begin to run into problems until I tried to go below 15mg a day. I experienced a sharp increase in tinnitus (ear ringing) when I tried to drop to 7.5mg once a week (a 7% drop). I immediately reinstated (went back up) to 15mg a day while I figured out what to do. After about a month, when I felt stable, I got 15mg tablets which I split into quarters and went down to 11.25mg one day a week (initially a 3% drop). As you can imagine, this took a long, long time. I did begin to experience some withdrawal symptoms - mostly sporadic, mild itching when I got below 15mg. You may or may not know that Remeron is a type of antihistamine (Boy, the things I've learned on this journey!). I would wait until the itching stopped before I tried another drop. This meant getting down to 11.25mg daily took me about a year. When nurses ask me about my medications, they won't accept that I take 11.25mg of Remeron, so I just tell them 15. They seem to get angry about it when I'm truthful. Sigh. I became quite ill for awhile from other things. First I was unable to get the generic bupropion that I had been taking for years (Mylan) and all the others I tried had awful side effects and/or didn't work. This went of for months and months. My doctor finally got my insurance company to spring for the brand name Wellbutrin which works great. But I was having other physical problems as well, and it didn't seem like a good time to try to taper Remeron when I was already sick. Now, 2 years since my last Remeron taper, I decided to try to get down to 7.5mg a day - again, by dropping 3.75mg once a week. I know Remeron has a half life of 20-40 hours, so I was alert to withdrawal symptoms after 2-4 days. Yesterday was day 4. I had a difficult night, didn't sleep well, and had a whopping nightmare this morning. I don't have nightmares. But I know that Remeron can cause nightmares and withdrawal from Remeron can cause them. I was also headachy yesterday and nauseated this morning. I don't know if either of these had anything to do with Remeron withdrawal, but I wouldn't be surprised. Titrating Remeron (rather than dropping once a week) is preferable, but it's a hassle to crush the pills and mix them with a solution and to get a prescription solution from a pharmacy is expensive. I'd also have to convince my doctor that I need to withdraw slowly and get him to prescribe the compound. In my experience, very few doctors have any idea how slowly one must taper off of psychotropic drugs. For some people withdrawal is easier than for others, but you have to listen to what your own body is telling you. Stopping abruptly or too quickly (I've done both) can prolong withdrawal symptoms. In my experience, it's better to reinstate to your last dose if you've withdrawn to fast and withdrawal is too painful or problematic. Slow down and regroup. Give your body time to adjust. You don't have to suffer. Take your time. I know how desperately some of us (me included) want to get off of these meds as quickly as possible, but it just ain't always that easy. I'm sorry this is so long, but 25 years is a long time, and my Remeron withdrawal journey started 5 years ago, so it's kind of a long story. It may sound like I'm only trying to give advice based on my own experience, but I'm really looking for advice and encouragement from others who have successfully tapered off of Remeron or the experience of others that are trying to. Thanks if you've managed to read through all of this, and I appreciate any comments.
  2. I finally screwed up by courage and tried the Wellbutrin 300XL. For a while, I took an extra 100mg of Mylan SR bupropion, since I have been taking 400mg total of Mylan bupropion daily (200 twice a day). None of the terrible side effects I feared (like the horrible constipation from the Sandoz generic bupropion) materialized. The brand name Wellbutrin was a dream compared to any of the generics. For the FDA to say that the generics are bio-equivalent is a joke. The 300mg XL worked so well, that I stopped taking the extra 100mg SR. I was worried that the XL would interfere with sleep, but it hasn't been a problem. As a precaution, though, I take the 300mg XL when I wake in the middle of the night. I have no problem going back to sleep or with it causing me to wake early. I know that by taking it at 3am, by the next evening I'll be coming down enough to sleep. It may be a purely psychological effect, but it's working for me. I was lucky in that my doctor was able to get my insurance company to pay for the brand name Wellbutrin. I guess is wasn't that hard for him, because he had a record of all the different generics I had tried (and I really tried them!) and the terrible side effects I had with all of them. I just have to hope that my insurance company will continue to cover the brand name Wellbutrin and that the company will continue to make it. It's the only antidepressant that has ever worked for me. I thought that anyone that happened across this thread might like to know how this story ended. I still take 20mg of Saffron daily (sometimes 40mg) and that helps boost my spirits, especially during stressful times. I've had no trouble stopping Saffron (I tried to see if I would experience withdrawal - I didn't). Good luck to all of you. I've been where you are. I may be there again. I just try to keep putting one foot in front of the other.
  3. Hi JaySueKay, You didn't say when you stopped taking the Wellbutrin. If I understand correctly, you took it for 4 days and then stopped, but you don't say how long ago it's been since you stopped. I "get" your sense of panic over your situation (been there), and that feeling of hopelessness that nothing seems to be helping. Sometimes you have to grit your teeth and hang on, which probably isn't helpful for you to hear right now. But you've only been on Prozac for 3 days and it takes 3 weeks or more for most antidepressants to kick in and start working. I'm sorry that the Xanax doesn't help either. I'm pretty old (let's just say over 60) and I've been dealing with these things for 50 years. What I've found out is that, however bad I feel at the moment, it will eventually get better. But the anxiety and awful things we're feeling don't help us to believe that. And anxiety feeds on itself. A good book that helped me was "Don't Panic." I managed to dig myself out of agoraphobia with that book. It helps to have someone to talk to (counselor, therapist) to tell them how you're feeling. If possible, try to see if you can reschedule some of your exams (your doctor ought to be able to give you something indicating that you are really ill). That feeling of "I have to do it!" and "I can't do it!" makes everything worse. Try to find yourself some wiggle room. Find someone to talk to who can advise you. I know what you're feeling, and I'm so sorry. I hope things get better soon.
  4. Withdrawal from any drug can sometimes be difficult. Particularly for antidepressants and tranquilizers. Most legit websites that know what they're talking about suggest tapering NO MORE THAN 10% every 2 to 4 weeks. Of course, this gets harder as you get to lower doses, but there are ways of making it work, because I've done it with a number of drugs. It's also suggested that you don't try to taper when you've got stressful events going on. I would taper once a month (we'll use tranquilizers as one example) and if I had a stressful month coming up, I'd skip the taper that month and wait until the next month. Most of us are in a hurry to get off of these darned drugs (I know only too well), but the faster you try to go, the more you suffer. They've also found that people are more likely to "relapse" and go back on a drug when they try to taper too fast. I've been there, too. I learned my lesson. Don't be afraid to taper a drug, but do it slowly. Take note of what withdrawal symptoms you're having, when they start and when they start to get better. Knowing what to expect each time you taper helps a lot with the anxiety. With benzodiazepines, I knew I'd get nauseated around day 8. I'd stay somewhat nauseated for a couple of weeks. You need to give your body time to adjust. Be kind to yourself, and take it slow. Suffering doesn't help. If you're having really terrible side effects from a drug, I can understand needing to get off of it more quickly. If you aren't, you can take it slow. It took me 2 years to get off of tranquilizers. It took me a year to get off of Aciphex, which is just for acid stomach! But a too quick withdrawal from that would've sent me into a tailspin of gastrointestinal agony. I'm working to get off of as many drugs as I can, but do yourself a favor - do them one at a time if you're taking a lot of them, and taper each one slowly if you can.
  5. Hi Empath, I feel your pain. I couldn't tolerate the constipation caused when I was taking Sandoz Bupropion SR (400mg daily). It reached the point that I no longer wanted to eat. I've read about people with chronic constipation becoming anorexic. I ran across other posts on the web, not necessarily from people taking bupropion, but from people with chronic, horrible constipation. Some had lived with it for years. One was a nutritionist! She discovered that the things she had been taught and was teaching others was wrong - at least for some of them. I ended up being directed to a book called "The Fiber Menace." Yes, the author is not a doctor, but a Russian pharmacist and the book is translated from Russian to English. It's not the best written book in the world but it sure helped me. I already knew from past experience that whole wheat bread tended to make me constipated. So when I began to read more and more about people having trouble with fiber, it began to make sense. A quote from the book: "according to the American College of Gastroenterology Functional Gastrointestinal Disorders Task Force: all legitimate clinical trials demonstrated no “improvement in stool frequency or consistency when compared with placebo." And yet, the same old line is always dragged out in response to constipation: eat more fiber. So I went on a low fiber diet, making sure to supplement it with vitamins, etc. Things began to improve. This was before Sandoz! I had been told to take Aleve for pleurisy and was on it for quite a while. That was the beginning of my problems. After I stopped Aleve and went on a low fiber diet, my gastro system was in pretty good shape until I began the Sandoz. Then, even the low fiber diet wasn't enough. I was trying all sorts of different laxatives - which I didn't want to do. It even took a while after I went off of Sandoz Bupropion and went back on Mylan for things to get back to (more or less) normal. I still eat a low fiber diet, but I've begun trying a few new things (see articles on transitioning from low fiber diets back to more fiber). I find that Magnesium Glycinate is helpful, as is Vitamin C - especially in the buffered form of Magnesium Ascorbate Vitamin C (I take the powdered form). Now Mylan is refusing to give even a prospective date that their bupropion will be available. I don't know what will happen if I can't get it when I run out. I tried taking one of the brand name Wellbutrin XL yesterday (the only thing they make now is XL). I ended up with the worst headache I've ever had. With the Sandoz Bupropion SR, it took a month before the constipation really hit, and it could be the same with the Wellbutrin - or it might not happen at all. But I can't live with daily excruciating headaches. I suddenly had a lot of sympathy for people who experience migraines. Any kind of pain reliever - even Tylenol - can slow down your system. Look at what other drugs you're taking, including OTC. Vitamin D - even a glass of milk with Vitamin D causes me constipation. Look up what drugs (including vitamins and supplements) cause constipation and see if you're taking any of them. Today I'm feeling really depressed, because if the headaches continue with brand name Wellbutrin, I don't know where to turn next. About the only generic I haven't tried is Heritage Bupropion, which seems to be readily available at most pharmacies, but some things I've read have made me wonder if it has a lot more bupropion in it than others (one woman said she had cut it in half). The FDA says bioequivalence of generic drugs is okay as long as it's anywhere from 80% to 120%! That's crazy! This is way more than you asked for, and it's rambling - so sorry for that. I hope some of this information helps you.
  6. Hi Laura, I see, I got it backwards (a sudden bout of dyslexia). You HAD been taking the SRs and he switched you to XL. And, yes, if you don't like the XL, demand to be switched back - and you don't have to wait until the prescription runs out. Ah, the good ol' days, when I could take my second dose of SRs at bedtime and sleep like a baby. Not any more. Just talked to Mylan late yesterday and the latest word is they don't have a clue when either the Bupropion immediate release 100s or the 75s will be available, so I'm going to have to put on my big girl panties, be brave and try the brand name XL. I'm afraid that I'll have side effects from the XL. Like my dog, I don't like change. I think Sandoz is a good alternative, but I had side effects that I couldn't live with, unfortunately. But it's good for many people. You may be right about the Pfizer buyout being a reason for part of the problem. These drug companies are constantly buying each other out, which makes it hard to know which version of a particular drug you're getting - is it the formula you've been taking or is it the formula of the company that just bought them? But it's not just Mylan that has a shortage. I've been reading that there's a shortage of many drugs and not all from Mylan. Hospitals are frustrated because they can't get the drugs they need. I haven't read a coherent reason for so many drug companies having shortages. They point fingers at the distributors, the retailers and everyone else but themselves. Canada is having a real problem, too, and has for some time. One U.S. hospital administrator commented that he's never seen anything like this drug shortage and inability to get common drugs. I've also read that it's not profitable to make some generic drugs anymore, and let's face it, big pharma is all about profit. I also read that a group of hospitals along with other partners are going into the business of manufacturing generics themselves. That's how bad it is. For people whose psychological and emotional balance is already fragile, not having a drug you depend on is a crisis. I'm glad I have Saffron as a back up. I've read comments by some folks that they were able to get off of antidepressants altogether by taking Saffron. I'm not advocating that. Great if some were able to do it, though. As far as Saffron goes, I take a supplement called Macuguard for my eyes and it just happens to have 20mg of Saffron in it. It's from a company I trust. I usually take one a day, but if I'm having a particularly bad day, I might take a second (the recommended therapeutic daily dose of Saffron for depression is 30mg). The other ingredients in Macuguard are designed to prevent macular degeneration and are recommended by many optometrists and ophthalmologists. I hope the Sandoz continues to work well for you. And if you're fed up with the psychiatrist, ditch him. You can try another psychiatrist and it might be different, or just go back to a primary doc. Hang in there. One thing I've learned. When the depression is bad, if I just hold on, it will eventually get better, even though the depression tells me it never will. My rational brain tells me that it always HAS gotten better. Hugs to you as another on this journey..
  7. Hi Laura, I was on Wellbutrin SR then Mylan Bupropion SR for many years. The downside to SR is having to take it twice a day, which was never a problem for me. If for some reason it does turn out to be a problem, insist on being switched back to XL. Some people have more trouble sleeping with one or the other. I liked SR because I could take it 8 hours apart (They say 8 to 12) and be "coming down" enough to sleep at bedtime. I usually woke up around 6am and knocked back my first dose of Bupropion SR and went back to sleep. That way I could take the 2nd dose in the early afternoon. You peak sooner with SR than with XL, just as you peak sooner with Immediate Release than with SR or XL. It could be that your Pdoc just made a mistake. If I have a written Rx I will always check it before leaving the doctor's office, because sometimes they're just distracted and I've often found mistakes. I've found mistakes when I've picked up drugs at the pharmacy that had been called in. Doctors have too many patients and too little time. Some of this is the fault of the system in which they are obliged to work. I could get into the same rant myself. I just switched ophthalmologists because I felt the one I was seeing was dismissive, and I just didn't like the treatment or attitude I was getting. If you are unhappy with ANY doctor (this includes therapists and counselors) after giving them a fair try, find another one. I haven't seen a psychiatrist in years for prescribing psych meds. I didn't find them any better than any other doctors - and you're right, the time you spend with them is very short. I've fortunately found a primary care doc who actually LISTENS to me and gives me feedback. We don't always agree, but he will listen to my concerns. You have to be your own advocate when it comes to medicine. A good book to read is "Your Medical Mind." Know as much as you can about any meds you are taking and make decisions based on what you know about your own body and how they affect you. I hate switching doctors, but I've had to do it twice in the last few years. If you're not happy with the shrink, find one you're happy with. Some can be real jerks (as in any profession). Or simply find another primary care physician that listens. My experience tells me that very few doctors, psychiatrists or other medical professionals know much about the medications they are prescribing. They know even less about withdrawal from the medications they prescribe (don't start me on that one). To cut them some slack, there are just too many meds and too many side effects. Don't let them make decisions for you. All decisions about medications should be by mutual agreement. Good luck! I feel that all of us on this forum are in this together. We are struggling with many of the same issues. It's not an easy life living with mental illness. I've suffered from major depressive bouts for the last 50 years. That means I'm OLD! This forum has helped me through some tough times. There is always someone who knows what you are going through and how you feel.
  8. My doctor actually got my insurance company to spring for the brand name Wellbutrin XL, but I'm not taking it. I discovered that 75mg tablets of Mylan Bupropion Immediate Release were available and I've been taking that some of the time (paid for out of pocket) because I've done well on Mylan Bupropion Immediate Release 100s, which, as far as I know, are still not available. Brand name Wellbutrin only makes XL now, no sustained release or immediate release. I took one of the brand name XL pills one day and had a moderate headache in the afternoon - which may or may not have been related to the Wellbutrin XL. I did have some trouble sleeping that night. So as long as I can dig up the Mylan Immediate Release, I'll continue to take that, since they have discontinued the sustained release. I can tell little difference between the sustained release and the immediate release, which is what I found when I read some studies of people being switched from SR to IR. I like immediate release because I can take it earlier and get to sleep earlier. If I eventually run out of Mylan immediate release, I will fall back on the brand name Wellbutrin XL and we'll see what happens. The last I heard, Mylan was supposed to have the immediate release 100s available at the end of April. So we'll see... Thanks to all concerned. I know that generic bupropion has been big problem for a lot of people, especially when pharmacies switch generics without telling you. Many of the bupropion generics out there are really bad. If you find a generic that works for you, make sure the pharmacy knows the specific generic that you want or have your doctor specify on the prescription that it is to be that brand of generic bupropion only.
  9. Saffron is an expensive spice, but it's important to get the best quality if you are going to use it for cooking or tea. I don't know where you live, but it's best grown in a very hot, dry climate. The best quality saffron for cooking comes from Spain or Iran, as I understand it. There is plenty of bogus spice sold as saffron, so if you buy it for cooking or tea, be sure to check out the quality and the supplier. I am definitely NOT a gardener, so I prefer the pills, as long as I trust the supplier. With the pills, I know exactly how much I'm getting. Having said that, many people prefer using the spice for cooking or tea. I know how it feels to barely be able to get out of bed - or just doing anything by sheer force of will. SSRIs never helped me, while bupropion has. But there again, not all bupropion is created equal, as we know. Most of the generics did not help me at all and gave me awful side effects, as I've said. I wish you much luck. Keep me posted on how your saffron experience goes.
  10. If you'll look at some of the research (actual research studies) done comparing the effectiveness of saffron as an antidepressant to an Rx antidepressant (Prozac is one I remember), they found it to be as effective as Prozac without the side effects -and no unpleasant withdrawal (something drug companies don't like anyone to talk about when it comes to antidepressants). I am a strong believer in reading actual research studies, though I'm also aware that statistics can be skewed to suit the researchers and whatever drug company is subsidizing them. Getting to the truth can sometimes be very difficult. The difference in this case, to my mind, is that no one has anything to gain by promoting saffron. It's been around forever, no drug company has a anything to gain by people using it and it can be used for cooking or to make tea - some people prefer it that way. I'm starting to feel more stable, so I'm thinking about starting the Wellbutrin XL. Mylan still maintains that they are going to keep making the immediate release and the XL but no longer making the SR, but that the immediate release in on back order. We'll see... This is off topic, but as an aside, my stumbling upon saffron was in my search for a vision supplement. Optometrists had been pushing AREDS on me for several years, but I was skeptical about the research, subsidized by Bausch and Lomb. The more I read, the more skeptical I became. I just didn't think AREDS was that great (my opinion), but it did contain some elements that could be helpful as vision supplements. That's when I ran across research about saffron as a vision supplement, not knowing about its antidepressant qualities. Imagine my surprise the first time I took it (I was relatively stable at the time but with my usual dysthymia) and suddenly I felt actually happy. I wanted to do things. I didn't know why. Later I found out it was the saffron. Since I've been going through more depression recently because of a lot of stressors, the saffron has helped to keep me afloat, it motivates me to get out of bed, to do things. I can't say I'm happy at the moment, but I'm used to not being happy. As I told my husband, I'm just glad not to be miserable.
  11. I feel your pain, Laura. Solco is awful. Other generics I tried gave me awful side effects, too. IMHO, the FDA is pretty much of a joke. I began taking Mylan immediate release when they discontinued SR and that worked out fine for me. It kicks in a bit faster, but that wasn't a problem. I thought I was saved. But suddenly, it wasn't available. First Mylan told me it was on back order until February. The last thing I heard (several weeks ago) was that it was back ordered until May. I can't last that long on what I have left. I finally threw in the towel, went to my primary care physician, and asked him to jump through the hoops for my insurance company to pay for brand name Wellbutrin. After my phoning the company that makes brand name Wellbutrin (the company used to be called Valeant, now called Bausch - these companies are constantly buying each other up and changing their names), I found that they ONLY make 150 XL and 300 XL. I've been taking 400mg a day and didn't want to go up to 450mg or down to 300mg. I told my doc to go for the 300 XL and I'd add 100mg of the immediate release to total 400mg. I'm hoping that will enable me to last until May - and hoping that Mylan will come through. But there's no guarantee that Mylan will have the immediate release available even in May. I've learned the hard way that the dates they give us are a moving target. I haven't started taking the XL yet. Sandoz is a good alternative for most people, but I had problems with it. The Sandoz SR caused me horrible constipation that I hadn't experienced with any of the others. I had to stop taking it. I've never taken any form of XL before, and I'm afraid that I'll have some of the same constipation issues with it that I had with Sandoz. I've gotten into my head that there's something in the extended release formulas that causes constipation (only speculation on my part). I could be completely wrong about that. I've been going through an extremely stressful time lately, and this medication issue is just one more stressor. I now have a 3 months supply of the brand name Wellbutrin XL but I've been afraid to start it. I've been trying to stabilize physically and mentally enough to try it (I first started many years ago on Wellbutrin taking the brand name SR and it worked great. When Mylan came out with the generic SR, I switched to that and never had a problem. I took it for years. It never occurred to me that it would suddenly become unavailable). If I'm stable, I'll be able to recognize any negative side effects of the Wellbutrin XL. I've read that some people have tried the generic Heritage immediate release (I don't know if they make SR), but apparently, it's too strong for some people - and they've had to cut their dose in half to tolerate it. We shouldn't have to be guinea pigs for pharmaceutical companies and the FDA, but we are. I'll add a hopeful note. I recently started taking a vision supplement that has saffron in it. I had read a lot of good things about saffron and how it could help your vision, which is one of my problems right now. What I didn't know, was that saffron is also an antidepressant. I got an immediate lift from the saffron without knowing why I felt better. I started reading about its antidepressant qualities. The supplement I take has 20mg of saffron in it. The therapeutic dose of saffron for depression, according to studies, is 30mg a day, divided into two 15mg doses. It has a short half life, and I can feel it wearing off by afternoon. It does help get me up and motivated in the morning. But saffron is a supplement, and you have to be really careful about who you get it from and how much you are taking. If you look at the reviews of saffron on WebMD, you'll see that many people use it instead of antidepressants. But read the research yourself. If you decide to take saffron, be careful who manufactures it and how much you are taking. Like all supplements and drugs, some people have allergic or unpleasant reactions, but most seem to tolerate it well. It's definitely helping me. As for Wellbutrin XL, I'm trying to be brave enough to try it. I went through of year of trying various generics and been burned so many times that I'm afraid of anything new. Wish me luck.
  12. Just spoke with Mylan. Now the Mylan Immediate Release is backordered until APRIL 27th. I was first told November, then told February. Today, the end of April. So I have to find an alternative. Because I take 400mg a day, there is no XL version of that unless I go to 450mg, which I don't want to do. 400mg is already a lot! I'm afraid of the constipation that might come along with XL. I can't take Sandoz SR for that reason, though it works great for a lot of people. I've read of other people being "speedy" on Heritage, which is what my pharmacy is offering me now. Actavis made me speedy - almost euphoric - in the morning and if I didn't time my second (SR) dose exactly right, I'd be falling asleep mid-afternoon. I mean, literally, couldn't keep my eyes open, passing out. As someone who has insomnia at times, it was kind of a nice feeling, but not at 5 p.m. Then bedtime would roll around and I couldn't get to sleep. I guess I could give Heritage a try, but it's scary. And I already have fluctuating tinnitus, and worsening the ear ringing worries me. One woman said she was going out of her mind when she was switched to Heritage and had to cut the dosage in half. Then she was okay. I "stockpiled" Mylan bupropion while it was still available, but I'll run out before April, so I've got to think of something. I was thinking of trying Mylan in the morning and Heritage as my second dose (or something) to try to get me through. I've got so many other problems in my life right now, that I really didn't need this one. I've spent so much time trying to research alternatives to Mylan bupropion over the past 18 months, that I sometimes feel I do nothing else. I know Solco is pretty awful. I had problems with Sandoz, Actavis and others. It seems that on most generic bupropions, people have nasty side effects or they just don't work for depression. I'm feeling really beaten down by the number of things I'm trying to deal with. As they say where I live, "I'm up to my a** in alligators." Except it feels more like up to my neck. I can't solve one problem before 3 more crop up. I'll say this, I started taking Macuguard for my eyes, and it has Saffron (good for eyesight) in it. Studies have shown that Saffron works as well as many antidepressants (don't try it until you check out the research and with your doctor. The therapeutic dose is said to be 15mg twice a day. And not all brands of Saffron are good) . I feel like it's the Saffron in the Macuguard that is keeping me going. Otherwise, I don't know if I could get out of bed. This is too long and TMI, but I'm so weary of fighting battles on so many fronts. I thought the bupropion problem was solved (with the Mylan Immediate Release) after a year of trying different generics brands of bupropion. No other antidepressant but Wellbutrin/bupropion has worked for me and I've tried many. SSRI's just don't work for me. Now I'm back to square 1. I even called Valeant and was told that they're only making XL now. I've also been on Remeron for 25 years and never felt it did me any good at all. Finally, about 4 years ago, I started very gradually lowering my dose of Remeron, eventually getting from 45mg a day to 11.25 (I'm good at cutting pills). I had no problems lowering Remeron until I got down to about 15mg and then I suddenly had allergies that I'd never had before. Basically, dependence on Remeron (an antihistamine!) has messed up my body's normal histamine response. I don't know what to do anymore. I've always been a problem solver, solving my own problems and helping other people, too. Now I've got too many of my own and can no longer find solutions just for my own. Sorry this is so long, but for those of you who made it this far, thanks for letting me unload. I'm open to any suggestions!
  13. I know i'm replying to an old post, but the simple answer is that you were given a different generic of bupropion. From your description, it seems to be one made by Amneal Pharmaceuticals. I've had problems with different bupropion generics. So have al lot of people. Find the bupropion that works for you and ask your pharmacy to only give you that brand.
  14. I know this is an old post, but there may be someone wanting to taper off Wellbutrin who, like me, will find it. I've tapered off a number of drugs over the years - not all were psychotropic drugs, but I learned that almost any drug you've taken fro a while is best tapered gradually. The recommended taper for psychotropic drugs (antidepressants, anti-psychotics, tranquilizers, etc.) is no more than 10% a month. I've tapered too quickly a few times and had to reinstate (go back up to a higher dose - but not all the way back up to the original dose) because the withdrawal symptoms were too severe. I understand the impulse, "I want to stop taking this drug NOW!" I've learned that it's best to start off with a 5% or 10% drop a week once a month a,nd see how your body responds. With Librium, I would start getting nauseated about day 8 and would be nauseated for about 2 weeks. Then I'd have 2 pretty good weeks a month. The nausea was tolerable. What helped the most was knowing what was going to happen. It relieved the anxiety over tapering a lot. Months when I was in a stressful situation, I didn't taper. Listen to your body. Doctors know very little about withdrawal. In general, they think people should be able to taper in a few weeks or a couple of months. That might be okay for someone who has only taken a drug a few days or weeks, but not for someone who has taken it for years. With Remeron, I started at 45 mg a day and tapered to 15 mg. Then began a succession of extremely stressful events. For a year, I stopped at 15 mg. Disappointed? Yeah. But, hey, I'd gone from 45 mg to 15 mg! I'm getting ready to start lowering my dose of Wellbutrin. I plan to drop one 100 mg tablet a week. I currently take 400 mg a day and I have for many years. That's less than a 5% drop a week! I'll do that for a month and see how my body responds - to see how much and how often I can taper. Slow and steady wins the race. People who taper slowly like this have a better success rate than people who go cold turkey or too quickly. And they suffer a lot less! For anyone who reads this ... I wish you luck on your journey!
  15. And NOW the immediate release (or regular) Mylan 100 is on back-order - perhaps until February! I just got an email from my mail-order pharmacy saying, basically, "We don't got it. We can't get it." What they offer is Solco, which is awful from my perspective. I read somewhere on the forum that it's the inactive ingredients in SR & XL generics that cause people a lot of problems. He said, if you have to change generics, go to a regular release. If you look up Wellbutrin online, you can easily find the graphs that show the release times (peaks and valleys) of the immediate release, the sustained release and extended release. I'm going to try the Sandoz again, I guess, but I'm going to try the immediate release formula. My insurance company is like the Wizard of Oz, they won't pay for brand name Wellbutrin, "Not no how."
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