Currently one 75mg Effexor, had been on Celexa for many years then decided I needed a change. The Celexa just made me feel numb most of the time and tired. Started Therapy about 18 months ago, has helped in some issues, not in some others. Went to see a Psychiatrist to get new meds. First was Wellbutrin, had little effect, doubled to 150mg. Loads of energy, couldn't sleep, agitated state, ego out of control, blood pressure up, but sure did like the energy it gave me. Next was Prozac (had worked for me years ago) did not seem to feel anything, then on to Effexor 75mg. Feeling okay some of the time, then decline into a depressed state. I am feeling frustrated, how am I supposed to feel if I am on the right medication and the right dosage? Happy? Numb? Energized? Am seeing my Therapist tomorrow and am going to push for some answers.