Dear DF, As there are so few posts on this forum that indicate much success with Prozac, I'd like to add one. At least, I hope it can provide some inspiration for those going through the start-up side-effects that can be disheartening to say the least. I've been taking Prozac for 5 weeks and 3 days. I started at 10mg for 5 days then stepped the dose up to 20mg. The side-effects at the beginning were the same as shared by a plurality of people new to the medication: daytime fatigue, insomnia, loss of appetite, feelings of depersonalization and hopelessness, anxiety. Essentially, an increase of all of the symptoms that one would start taking Prozac for in the first place! This is not new information. You can find any number of posts on this forum with identical complaints, and I can commiserate with them all. When you're trying to recover from a depressive episode, this intermediary stage, a depression purgatory, can seem endless and hopeless. We think, "how long do I have to wait, to bear these horrible feelings before I feel an improvement? Will I ever feel an improvement?" And rightly so. Not all medications work for all people. However, for me, things started to look up after 5 weeks. After the initial feelings of fatigue (the first couple of weeks), all I felt was a steady bluntness, a mental neutrality with neither the ability to feel happiness of sadness. This sensation is disturbing to say the least, even for those of us looking for respite from negative thoughts. I wondered if this was it, if this was what Prozac "does." It numbs you permanently so you don't have to feel the wildly undulating sea of emotions that life brings. But I'm starting to feel that sensation lift slightly more each day. I'm also feeling my body adapt to the decrease in sadness. At first, it manifested itself as increased anxiety, which caused me to essentially isolate myself for the last month, just barely getting through work and coming home each day numb and exhausted. Ativan would calm the panicky feeling, but it turned me into even more of a zombie. I've been taking the Ativan later and later in the day, and at decreased doses. Within the last week, I've been able to get through the entire day and evening without taking it. I take .5mg at night before bed, but I'm planning to reduce and eliminate the benzo altogether. I'm now adapting and embracing the new energy, and I'm learning how to channel it away from anxiety and towards happiness. For example, there's an organization I belong to and feel very strongly about. However, I had missed the last two weekly meetings as stress from work and feelings of sadness and anxiety prevented me from attending these highly charged and often mentally exhausting political debates. This week's meeting was last night, and I thought of the myriad ways in which to cop out of going. But I told myself to stop running from these engagements, that it's time to embrace being more social again. So I went. And you know what? I had a great time and was not too anxious either, and this was without Ativan. I was talkative and glad to hang around after the meeting to chat with people and make future plans. I almost could not believe it! This was not possible for me to do even a week ago. I see this as extreme progress, and I'm sure the Prozac is helping. Or at least it's no longer hindering. Perhaps this feeling won't last forever, and I know it will change over the next few weeks as the medication settles in my system. But for those of you going through the startup process of Prozac, I hope this can provide some hope that things will get better. -S Frye P.S. - In addition to the Prozac, I've been doing Astanga yoga most every day for about an hour, and 2 mile runs 3 times a week. I think the yoga has been as important, if not more so, than the Prozac. It's allowed me to focus on myself through breathing and meditation, and my breath is at least twice as long now as it was a month ago. The length of the breath creates such a calm in me. Once you start paying attention to your breath, you realize how shallow you breathe when stressed or anxious, and that you can use your breathing to calm you down anytime, anywhere. Be well.