Well, now that I think about it, a lot!!! I am only on a crumb of Zoloft now, but in the past... SERZONE~About 8 years ago for about 9 months. It helped the anxiety but made me a little numb. BUSPAR~For a few months after the Serzone. Worked well for anxiety, but made me lazy. I realize now, my dosage was too high. CELEXA~Two weeks. Hated it. Felt in a total fog and couldn't think straight. Maybe I didn't give it enough time? PROZAC~For two weeks. Gave me severe migraines. Had to stop even though I liked it otherwise. Sexual side effects too. ST. JOHN'S WORT~For a few months. Helped a little with depression. Made my eyes very sensitive to light. Helped decrease appetite a little. Don't remember why I stopped it. 5-HTP~For a few months. Worked a little. Don't remember why I stopped it. NATURE'S SUNSHINE MOOD ELEVATOR/Chinese Herbs~Slowly helped me feel pretty good, decreased depression and anxiety. Then I moved away from store I was getting it from, and stopped. Then wanted to get pregnant and felt decent enough to stop everything. So, nothing for about 5 years and just dealt with irritability and anxiety as it came. Then major depression came... WELLBUTRIN~For about 9 months helped depression immediately and totally. The first 2 weeks was H E L L!!! Then it was great. Decreased appetite, too, and increased libido, more energy!!! However, due to life changing events, I could not handle the anxiety from it anymore and had to go off since I could not split the pills and take less. Also, major word loss. LEXAPRO~About 1 month. Made me angry and some sexual side effects. PROZAC~For about a month. No migraines, but felt a little foggy and had major sexual side effects. ZOLOFT~For about a year now, found a decent low dosage. It helps with anxiety a lot and depression a little. Decreased anger. too. Some sexual side effects, lowered libido and more difficult to O. However, not bad enough to stop the Z. Also, slowly gained 15 lbs over 6 months. Not good. Staying on small amount. Tried to go off but found out I needed my "crumb." Also, XANAX or VALIUM when absolutely necessary which is rare, like once every three months. So, that's where I am now. I still may try Straterra also to see if can help with focus and motivation and energy. However, my insurance won't cover it since I am not diagnosed ADD (even though I am slightly ADD), and it's $4 per pill!!! That was kind of fun and interesting to do. When you have time, do the same. It makes you remember the journey you took to get here even though some of it was very difficult. Hopefully you will all find something that works and helps.