I'm taking Celexa at night before bed right now, and I do pretty well getting to sleep. The first three weeks it made me really tired in the morning, so I slept in late. Now after about 5 weeks I am finding I can get up easier, though still tired, so I may switch to the mornings soon. I'm sure you get more benefit if you take it in the morning. I really don't think the time of day matters with how much of a benifit you will get from the medication. You just need a steady level in your blood (basicly take them at the same time every day).