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    GeorgeR got a reaction from Troydg in 2 weeks so far on Wellbutrin ... moody   
    Hi- hopefully it'll get better for you soon. I can share my experience since it's fresh- I've been taking Welbutrin for about 14 weeks. I didn't get much out of it for quite a while, aside from sleepiness you got. I called the doctor after 3 weeks of no real improvement and he said give it at least a month and it could be as much as 8 weeks to see results. He said for most of his patients on Welbutrin it's more like 4 weeks. Since everyone's different there's no pat answer. I started on 100mg and ramped up to 300mg (200 in the morning and 100 in the afternoon).
    Anyhow- in my case I got nothing until 8 weeks and then bam- I was relaxed and no more semi-constant angry and lazy. Then 2 weeks later I got some energy back- quite a bit in fact. I know that's a long time... really I know 😄 but since I'm not working because of Covid I agreed to the long wait my doc suggested. Happy I did. Hope this helps.
  2. Like
    GeorgeR got a reaction from Troydg in Difficulty sleeping   
    I'm a major lightweight when it comes to medications these days. Funny thing is the opposite was true back in my rambunctious college days 😄 
    After laying awake so many nights I was a daytime zombie-- add to that 50mg of Trazodone, which works for sleep but leaves me dizzy, weak and seeing stars during the day so I decide to switch gears; I'm weaning off the Wellbutrin now. That's a real shame because it work well for depression plus I get the energy boost too. Insomnia just isn't worth it though 😞  In case you're just tuning in-- I tried 4 other sleep aids and they pretty much did nothing. 
    Starting first 5 days ago I lowered my 200mg morning dose to 100mg and continued taking 100mg more in the afternoon. The first night I took only 25mg of Trazodone but added 5mg of Melatonin. Right off the bat I got a great night's sleep but by day 3 I was back to being up for 3 hours in the middle of the night. Yesterday I dropped down to 50mg Wellbutrin in the morning, still 100mg more in the afternoon. And at night 25mg Trazodone and 7.5mg melatonin-- had the best night of sleep in months! I hope for a repeat tonight. Gonna continue the 5 week titration and then decide what to do at that point. Thanks everyone for your support.
  3. Like
    GeorgeR got a reaction from sober4life in Difficulty sleeping   
    50g of Trazodone is wiping me out so I'm gonna halve that and supplement with 2.5mg of Melatonin and see if that's any better. On the bright side-- I've had 2 good nights of sleep in a row. The saga continues 🙂
  4. Like
    GeorgeR got a reaction from violeteyes in Difficulty sleeping   
    Thanks for the info folks. 25mg doesn't work at all and last night I took 50mg and still only got 3 hours of sleep. I'm not giving up on it yet though. This morning the hangover feeling wasn't bad, which was nice. Regarding the rash, aka SJS syndrome-- the doctor did warn me in no uncertain terms and told me to look it up online. Yikes! Thanks for mentioning it. 
  5. Like
    GeorgeR got a reaction from Troydg in Difficulty sleeping   
    Good news bad news: the good is that 50mg makes me sleep well. Bad news is 25mg doesn't. Slightly not good news is I'm pretty hazy in the morning after that 50g dose. Hopefully I can get used to that and not let it slow me down.
    Yesterday I asked the doctor about staying on the Wellbutrin/Trazodone regimen. He and I were both ready to begin making the (really really long) switch to Lamictal but between the good sleep and stuff I heard from you guys here I felt it's definitely worth at least staying the course for a while. I'm a little worried that I'll need to take Trazodone every night though because Wellbutrin obliterates my ability to fall asleep. Before about 10 days ago I always fell asleep easily but got up after a couple hours and had trouble going back to sleep. Actually the first several weeks on Wellbutrin I was able to sleep just fine. Now it just keeps me up all night. Thank you Trazodone 🙂
    Maybe this will help someone-- my titration instructions (slow because all these medications hit me really hard). This is the plan if I change from Wellbutrin to another AD. Now I take 200mg in the morning and 100mg in the afternoon. Goes like this: first week 100mg each morning and afternoon. Second week reduce one or the other [am/pm] by 50mg. Week three reduce the opposite time by 50mg. When I get to 50/50mg I'd start up on the Lamictal. This slow titration is partly because I had a headache and was angry for fully 3 months the last time I weened off an AD medication. Also it's to be clearer on what the new medication is doing. Switching right over makes it hard to know if the changes are from the old med or new. 
  6. Thanks
    GeorgeR reacted to Troydg in Difficulty sleeping   
    I'm sorry to hear you had another rough night. I hope you respond well to Trazadone; or are able to find the outcome you are looking for. I'm still trying to find a bedtime routine (ritual) that will help with my sleep hygiene on top of the trazodone. Keep on trying and keep us posted. Good luck. 
  7. Thanks
    GeorgeR reacted to Troydg in Difficulty sleeping   
    I started taking Wellbutrin (Bupropion) about 5 weeks ago (like it very much and effect still seems to be growing).  I had pretty significant insomnia prior to taking Wellbutrin, so my Doctor prescribe Trazadone out of the gate. I had an amazing night of sleep at the first dose. Initial RX was for 25 mg, can go up to 50 mg - but I've been able to keep it at 25 (only take 50 if I have a particularly "busy mind" at bedtime. Easier to fall asleep - and if I do wake up it's brief and I go right back to sleep. (Dreaming for the first time in years!!)
    Now, the important stuff - while I try to get a full 7 - 8 hours a night and waking up well rested, if I have a short night of 6 hours or so - I might be a little groggy, but nothing a quick shower can't wash away.  It is not habit forming, and I can easily skip a night if I need to. In fact, I feel like it has improved my overall sleep hygiene that my sleep has gotten better rather "organically".  With my Doctor's okay, I continued taking 3 - 6 mg of melatonin, also. 
    Bottomline, I am extremely pleased with my combo of Wellbutrin and Trazadone. 
  8. Like
    GeorgeR reacted to Epictetus in Difficulty sleeping   
    Hi GeorgeR,
    I'm sorry this is happening to you.  Unfortunately I have no experience at all with Wellbutrin.  I am on Celexa now and was prescribed Trazadone for SSRI insomnia.  Some nights are very difficult though so my heart goes out to you.  Hopefully people with experience taking Wellbutrin will see your post and respond to it with something really helpful.  I sure you hope you find something that can help with sleep/wakefulness problems!
  9. Like
    GeorgeR got a reaction from Troydg in Difficulty sleeping   
    Thanks for the support. Wow- last night I took the whole 50mg like I said and I slept like a log straight thru the night- 9 solid hours😁  Haven't done that in months. It's a fair assumption that the giant sleep debt I built up had something to do with that heavenly night but maybe all I need is to take the whole 50mg to sleep. However that experiment turns out-- after I talk to the doctor today there's gonna be an alternative on deck in case Trazadone doesn't continue to help me sleep. Lamictal maybe- that looks like a good candidate and doesn't have any big conflicts with my health situation.
  10. Like
    GeorgeR got a reaction from Troydg in Difficulty sleeping   
    Last night was worse than the night before. I hope to report that Trazadone works. I have the same 50mg pills that need to be cut in half. Apparently the risk of QT prolongation is not a problem with small doses.
  11. Like
    GeorgeR reacted to mikl_pls in Trazadone   
    200 mg is the max dose for sleep, because after that, the blood levels of the active metabolite, mCPP, raise to a level where the medication actually becomes stimulating rather than sedating. 300-400 mg, as @ladysmurf said, are for depression outpatients, and 600 mg is the maximum dose used for depression inpatients. That's a lot of trazodone! 😮
    If you have developed a "tolerance" to this med, which often happens to many people, including myself, you may wish to discuss a different sleeping med with your doctor... Something like low-dose Seroquel (25-50 mg), low-dose doxepin (10 mg)/Silenor (3-6 mg), low-dose Remeron (7.5-15 mg), Belsomra, Rozerem, Atarax/Vistaril, Saphris (if your insurance will let you get it without step therapy), Ambien/Ambien CR/Zolpimist/Edluar, Lunesta, ProSom, Halcion, Restoril, Ativan, Serax, Dalmane, Doral, gabapentin, etc. Heck, even low-dose Thorazine will definitely get the job done! (25-100 mg) Just watch for acute dystonic reaction to Thorazine... it happened to me my first time taking it (I took half a 100 mg tablet), but never again thereafter.
    Seroquel and Saphris are atypical antipsychotic, newer than the typical antipsychotic Thorazine. A word about Saphris, it is sublingual only, and tastes awful. They try to add some cherry flavoring in there, so it tastes like a disappointing cherry liquor... lol
    Doxepin (Sinequan) is a tricyclic antidepressant, but at low doses and even microdoses (Silenor), it acts as one of the most potent antihistamines and puts you to sleep. Remeron is a NaSSA (Noradrenergic and specific serotonergic antidepressant) and is, I believe, the most potent antihistamine on the market, but it will definitely put some weight on you and increase your appetite--some people need that, some don't.
    Rozerem is a melatonin receptor agonist at MT1 and MT2 receptors, but one could arguably just take melatonin (low dose) and get the same effect.
    Belsomra is an orexin receptor antagonist. Orexin is responsible for wakefulness, vigilance, feeding behavior, and energy expenditure. Antagonizing the receptors (blocking them) keeps orexin from making us want to stay awake more. It's a pretty good medicine, I must admit (when it works, it's a little hit or miss for me). You have to titrate up to your dose though, whereas some doctors and pdocs just prescribe the max dose of 20 mg right off the bat.
    Atarax and Vistaril are the same medicine (hydroxyzine), except the Atarax is "hydrochloride" and VIstaril is "pamoate," the latter of which permeates the central nervous system more easily and can thus help you with anxiety and insomnia, however you take it. The pamoate is a capsule though (Vistaril), so it can't be split if you discover 25 mg or 50 mg is too high a dose for you.
    Ambien is zolpidem, a nonbenzodiazepine or "Z-drug." It has some variations out there, including Ambien CR (controlled release), Zolpimist (oral spray, tastes worse than Saphris!), and Edluar (orally disintegrating tablets). Lunesta is another Z-drug, but it lasts a little longer than Ambien and probably even Ambien CR. Definitely lasts longer than Sonata (which I didn't include because it only works for sleep induction, not sleep maintenance, but if that's all you need, I'd recommend Sonata actually. It worked far better for me than Ambien.)
    Halcion and Serax are short-acting benzodiazepines; ProSom, Restoril, and Ativan are intermediate-acting benzodiazepines; and Doral and Dalmane are long-acting benzodiazepines. You could throw Klonopin in there too for a long-acting one. It's generally better to stay away from the long-acting ones for sleep as you may likely experience next-day sedation (hangover).
    Gabapentin (Neurontin) is an anticonvulsant that has pro-sleep properties. It doesn't necessarily make you go to sleep, it kind of "lets" you fall asleep. It may be good as an adjunct medicine to your sleep medicine. It promotes slow wave sleep if I recall correctly.
    I hope this list is of some help to you, and if not you, then somebody! lol 🙂
  12. Like
    GeorgeR got a reaction from Oscar K in A cry for help   
    Please please get to a doctor. Explain the situation or simply read what you just posted to the doctor. 
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