I, too, had severe anxiety (as I have had for the previous three months) when I began taking Cymbalta for the first time today. Within one-half hour of my first dosage, I have almost no symptoms of anxiety, maybe zero. I am shocked that my panicky anxiety virtually disappeared with one dose. A sick feeling has overcome me, however, which I hope will subside (nauseousness, sleepy, stomach ache, clamminess, no energy).