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  1. Hiya, I recently completed TMS which seemingly did nothing to improve my depressive symptoms. My psychiatrist has recently prescribed Paxil along with Wellbutrin (starting doses 20mg and 150mg respectively). Has anyone had success with this particular combination? Looking for some hope and of course any honest opinions, whether positive or negative. I read on another forum that this is a good combination but that you need to be careful to not have too high a dose of Wellbutrin, as Paxil inhibits its metabolism - can anyone shed any light on this matter? Surely if the paxil inhibits wellbutrin's metabolism then you would need a higher dose of the wellbutrin to counteract this problem? (or just not use the combo at all if they are incompatible). I am currently tapering off of my cymbalta and I will be starting this new combination on the 19th January. Thank you in advance for any help, sending lots of love and hugs to you all. Wishing you all the very best for 2020. Ryan x
  2. Hi guys, I hope I am able to share this here, I am currently raising funds for travel expenses so that I can undergo TMS treatment and I do not have friends that I can share this with. Here is the link to my page: gf.me/u/v9abpb I will also post my story here if you wish to read it. For many years now I have struggled with recurrent depression, ranging from mild episodes to severe episodes. I have exhausted many treatment options ranging from talking therapies to various medications, yet I still continue to struggle with this debilitating condition. My current depressive episode has lasted 7 months and I am reaching the end of the road in terms of available treatment options. Roughly two months ago I scoured the internet for clinical trials in the hopes that I would find new treatments which I could try. I stumbled upon a clinical trial for a relatively new depression treatment called 'Transcranial Magnetic Stimulation' (or TMS, for short), I read the description of the procedure and it sounded daunting, but I knew that something had to be done as I could not envisage myself continuing down this dark road for much longer. Here is a brief description of what transcranial magnetic stimulation is (from 'mayoclinic.org): 'Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. TMS is typically used when other depression treatments haven't been effective. This treatment for depression involves delivering repetitive magnetic pulses, so it's called repetitive TMS or rTMS.' I applied for the TMS trial and waited a month before I could undergo an assessment due to the waiting list. This week I attended my assessment and I have been accepted for the trial. However, I still desperately need help with travel expenses as I am required to travel from Kent to London on a daily basis for 4-6 weeks to undergo the procedure, and being currently off-sick from work I simply cannot afford to pay for the travel expenses and my family cannot help me with raising the money at this moment in time. My treatment is due to begin in 2 weeks time and if you can donate just a small amount of money then this would be so very much appreciated. You would be helping me on my journey to overcome this horrible condition which affects so many people in the world. Thank you for reading.
  3. Hiya! I'm really glad to hear that the Vraylar is having such a positive effect on you so far! Wishing you the very best with your treatment. Sadly I've felt no improvement in mood with the 150mg serequel XR so far (I realise it's still early days though!). You said that the serequel starts to inhibit the reuptake of norepinephrine at 150mg - is that the same for the other antidepressant mechanisms of action that you listed? Are the other mechanisms dose dependant too, and thus only begin working at 150mg? I'm just wondering because obviously my Cymbalta already inhibits norepinephrine too, so surely my only one of my two medications can inhibit the reuptake of norepinephrine? I hope I'm making sense. I'm just hoping that going up to the 150mg serequel will be a worthwhile move on my part and that there will be some antidepressant efficacy beginning soon. Thanks again for all of your help.
  4. Hi guys, I have seen a doctor (he was a trainee GP) and he reluctantly upped my dosage of serequel XR to 150mg. The increased dose made me feel weird when I took it last night and I started to become a little panicky, felt drunk when I woke up in the morning too but thankfully the dizziness has subsided a bit throughout today. I'm really hoping that this combo does the trick, if not then I might try Effexor in combination with the serequel instead. I'm just so sick of feeling rubbish, getting desperate now.
  5. I'm from the UK and over here it is seemingly very difficult to get a referral to a psychiatrist unless you are a danger to yourself or others. Very frustrating. I am going to ask again tomorrow when I see my GP if he is willing to refer me a psychiatrist but I am almost certain he is going to say no. Thank you so much for all of the very useful information about serequel's antidepressant mechanism of action. You explained it very well. I did have a high amount of anxiety when I was prescribed the serequel, yeah. I was also experiencing feelings of derealization but I personally believe that was due to withdrawing from mirtazapine at the time. I felt like I was in a dream world when I was on mirtazapine and then I crashed back to reality when I withdrew from it and I think it just confused the hell out of my brain and caused oodles of anxiety and panic. Can I just ask why you feel that Abilify or Vraylar may be better choices? Do you think they might work slightly better in terms of treating the depression?
  6. Thank you Tim! It's good to hear that you had decent results with Cymbalta for a number of years. I will be asking my questions to my GP tomorrow and if he says that he is unsure of any of the answers then I am going to ask if I can be treated with someone with more knowledge on the subject.
  7. Hi all, 9 weeks ago I began Cymbalta and Serequel XR for depression and I have felt little improvement in my mood. 1 week ago I went from 60mg to 80mg duloxetine daily, but I have consistently been taking the serequel XR at a 50mg dose for the duration of my treatment. My GP seems reluctant to up the dosage of the serequel at this point and I am confused as to why, as from what I have read online serequel XR begins to be effective as an adjunct to antidepressants at a 150mg dose, at which point it begins to inhibit the reuptake of norepinephrine. However, from my understanding Cymbalta is already a potent inhibitor of norepinephrine, so what possible antidepressant benefit am I getting from this combo? Is there some antidepressant synergy with my current two medications or not? My doctor seems to know about as little as me about these things, which is why I've come online to ask you guys instead! Has anyone had success with a similar combo of meds as mine? And can anyone here possibly attempt to explain the antidepressant efficacy of this combination of meds? I'm contemplating coming off the serequel entirely as I worry that it is possibly negating the effect of my Cymbalta by blocking serotonin and dopamine (I assume that at a 50mg dose it is highly unlikely that the serequel is blocking much serotonin or dopamine, if any at all, but I still worry). The pharmacology of medications is so confusing! Would you guys suggest that I try coming off the serequel or possibly increasing it to 150 mg? (the alleged antidepressant dose). I'm also confused as to why my GP started me on BOTH medications at the same time, as it surely could have been possible that the Cymbalta might have worked on its own. Ugh. It's all so very confusing, If anyone can be of any help here at all then I'd appreciate any information and advice. By the way, my GP currently refuses to refer me to a psychiatrist at this point as he says that my depression is not severe enough. Thank you. Sending lots of love and hugs to you all. Ryan.
  8. Feeling absolutely terrible today. Starting to think I'd be better off in hospital than I am at home.
  9. Hi all! Thank you so much for all of the lovely words and support, it really does mean so much to me. Today is not a great day, but it is another day that I know I will survive. Just have to keep pushing on!!! I have a question regarding taking supplements along with an antidepressant. I have read a few articles online that state that taking some supplements along with your antidepressant can interfere with the effectiveness of the antidepressant? Some sources say that omega 3 fish oil and vitamin D3 supplements can boost the effect of the antidepressant, but I have read that too many B vitamins can hinder the antidepressant? I've also read that vitamin K and E can hinder the effect of the antidepressant too. This worries me, as I take a B complex supplement and my multivitamin contains vitamin E and K. Does anyone here know exactly what supplements are okay to take with an antidepressant? I don't want to continue my current regime if it is preventing me from getting better. I hope you guys are doing well today. Sending all my love and hugs to you all.
  10. Hi there! Thank you about the drugs and alcohol, I'm really proud of it. I already take a B12 supplement along with my multivitamin, but I have just purchased some magnesium too. Thank you for the tips! I haven't had my thyroid checked, no. I have a doctors appointment next week and I am going to mention having my thyroid checked as I am really at my wit's end with depression, it really does feel like my brain wants to **** me. It is the most horrific and isolating darkness. I felt weird and flat on the mirtazapine, but at least I was able to function. Today has just been terrible. I feel hopeless, I have no energy and I'm just so tired of fighting this illness. I feel broken. I went for a walk earlier but I'm not sure how much it has helped. My doctors have been aware for some time of my alcohol and drug abuse and they also know that I have now completely cut out both of those substances.
  11. Hi all, my name's Ryan. Long-term sufferer (and survivor!!) of depression and anxiety. I'm 29 and from the UK. Well, long story short, I am currently unwell and in the midst of a depressive episode. 3 years ago I took sertraline for depression, social anxiety and GAD. I achieved remission after about 6 weeks with the sertraline, the medication helped me enormously for about 2 years and then seemed to 'poop out' (although I was also drinking at the time, so in hindsight it's difficult to say whether or not the alcohol was rendering the sertraline ineffective). I was also taking cocaine during that period, which was bound to be having a negative impact on my mental health too. The doctors have changed my sertraline to various other antidepressants since then. I have been on citalopram, venlafaxine and most recently mirtazapine. I was drinking whilst taking the citalopram and venlafaxine, so again it is difficult to say whether they would have worked if I hadn't been drinking. I took the mirtazapine for 5 months, it helped me sleep and enabled me to function but I felt persistently flat, I didn't really want to be around people, I was very anxious and everything felt SO surreal, like I was in a dream-world and everything around me had changed permanently (and not in a good way!). Anyway, 4 weeks ago I was prescribed Prozac and was told to take 15mg mirtazapine for two weeks before starting the Prozac at 20mg, I ignored this advice and convinced myself that Prozac and mirtazapine would be a good combination for me. The combination for those two weeks did not help, and I started having very bad panic attacks. I had some mirtazapine left over and continued to take the Prozac with the mirtazapine for a further week before deciding enough was enough as I felt unwell. 7 days ago I stopped the mirtazapine 15mg completely and it's been absolute hell for me since then. I woke up on Tuesday with such a sense of dread, I was due to go to the dentist at 11am and then to work at 1pm and I had to cancel the dentist and phone my boss to explain that I needed some time off due to depression. I feel that I have completely reverted to how depressed I was three years ago, if not more so. I have a partner and I do have some friends, but naturally I've been isolating myself because I just feel unable to function. I'm supposed to be going out to see my friend for her birthday drinks on Saturday, but lots of people will be there and I just know it is not a good idea right now. To clarify, I am no longer drinking or taking cocaine. I have not had a drink in 4 weeks and I haven't taken cocaine in many months. I'm taking a multivitamin along with my 20mg Prozac and I am just praying that I achieve remission soon. I've started to think all sorts of crazy stuff, like I'm resistant to medication now, or perhaps I have a thyroid problem which is causing my depression, etc etc. It is just so frustrating and such a scary time. Getting out of bed is the absolute worst. I'm having all sorts of symptoms since stopped the mirtazapine: deepening depression, terrible anxiety, nausea, no appetite, my blood feels like it's running cold. I was such a positive and outgoing person for such a long time on the sertraline, I am just praying that the Prozac kicks in soon and I have a similar recovery as I had with the sertraline. Should I remain hopeful with the Prozac? Everything feels so hard right now. Sorry for the extremely long and boring rant, I'm off for a long walk now as I know that staying in my room all day is not the answer. Sending all my love and hugs to everyone here, we're all in this together and we have to believe that we WILL recover!!!!!
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