Hi there. I am not an amputee but I have taken care of my aunt who is recently a double amputee. She too feels helpless and depressed most days. After a long battle with diabetes she ended up losing her left leg due to an infection on her foot. 5 surgeries in 5 days resulting in an amputation just below the knee. Talk about a life changer. She is 54 yrs old. She moved in with me and I began the journey of nursing her back to health and fighting with insurance to get her a prosthetic. It took about a year but she did become mobile again. After about 6 months she developed a blister on her right foot. After 3 months of IV antibiotics (the strongest kind) at home she ultimately lost that leg as well. I thought for sure she would rapidly decline. Now her wheelchair is her only means of transportation. For the depression she takes a low dose of celexa and buspar for a booster. Although I am not sure how I would deal with it if I were in her shoes but she is doing aloy better. Lives on her own, cooks, cleans, watches her new grand baby, and enjoys life from a sitting down position. She still managers to except what she can not change and make the best of it. I will be praying for you friend and I hope you find peace. Always here to talk if you need a friend who can relate.