The most important thing is to talk to your therapist first, he/she is the most competent person to help you switch to another medication. Plus, you will need guidance when it comes to switching since quitting Cymbalta can have some nasty withdrawal symptoms. I had the same issue as you, all of a sudden it was doing nothing for me, after years of taking it. I switched a month and a half ago and I'm seeing some improvement, still got a long way to go, but it's helping.