No, I haven't gained an ounce. Also, my p-doc didn't say anything about increase/decrease in appetite due to Emsam. My speculation is, that because I have slightly more energy, my body is demanding more "fuel" ... that's just a complete guess. I hear you. Xanax was the first thing to ever control my panic attacks and, what I call "anger attacks." It's hard to tell because I'm only on the 6mg now, which is the "starter dosage." On 6mg, Emsam only stimulates 1 enzyme responsible for mood. At the theraputic dose of 9mg, it begins to act on 2 enzymes... and that's when it's supposed to work full throttle. Some people need 12mgs. Anyway, I start the 9mg tomorrow. Here's what I've noticed so far, the good and the bad. Cons: Increased appetite, but again, this may pass or be due to having more energy. Pros: I'm using less Xanax.... down by about .5mgs a day. I'm clear headed and not in a "SSRI fog," which is what I'd felt previously on other meds. Haven't had any major crying spells. I did get teary twice this week... but hey, I was watching Oprah, so don't know if that counts, lol. Hasn't effected my sleep - no insomnia or drowsiness. Not as tired during the day. ------ So overall, I'm not ready to rave about mood and anxiety improvement, but I am impressed that the side effects are practically non-existant. My pdoc said I'd need to be on the 9mg patch for at least 12 weeks to ascertain how effacious it is for me. Btw, this is the last AD my pdoc is trying with me. If it doesn't work, he's suggesting ECT or VNS.