Dr increased my dose of bupropion from 200 to 300 ir two weeks ago. The last 4 days I have experienced waves of heat about 1/2 hour after taking one but especially bad at night, even though I have taken it in late afternoon. Also extreme anxiety about going out, or to a restaurant, rage and insomnia as well as difficulty urinating Is this a sign of overdose? I was on this drug at 300 mg sr for 25 years, yes 25 years. But due to a stomach operation for Gerd I can no longer metabolize the Sr. Since this switch my life is hell. I am 73 years old been on most anti depressants some along with bupropion, and this one worked the best. Now I am so miserable. Has anyone had this happen? I am thinking the extra 100 is too much and that heat waves may be a sign of a seizure coming on. My quandry is to hang in or I am having an allergic reaction?