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mikl_pls

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About mikl_pls

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  • Birthday 09/11/1987

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  1. I don't know much at all about EMDR, but I would say it's probably okay to take Xanax before and after. If in doubt, speak with the therapist who is doing the EMDR for you or your pdoc. Yeah, BuSpar, if it works, will take a couple to a few weeks to start working.
  2. My pdoc has me to take half to a whole pill as needed three times a day. In my experience, taking half a dose three times a day regularly, around the clock, instead of as needed is all I need, and I don't even need it all every day. If I take an as needed dose, I do take a whole one, but I'm very benzo resistant, so it takes much more Xanax to make me experience side effects. Sorry, I don't think all this answers your question... lol I think you have a good idea there. If not, you could ask your pdoc if you can take half a tablet around the clock like two or three times a day, which might benefit your anxiety when it reaches steady state levels in your body without side effects. Not trying to tell you how to take your medicine or anything, but just thought I might make a suggestion to consider with your pdoc. 🙂
  3. I believe so. I think you might do better for depression with 300 mg XR though. 150 mg isn't quite enough to affect depression.
  4. Thank you kindly! I wouldn't say Latuda and Parnate counteract each other in regards to dopamine, but I'm not an expert on this. Also, I had no intentions of telling you how to take your meds when I was talking about your insomnia meds. I was just making an observation and possible suggestions to bring up with your pdoc. 🙂
  5. Hope it works better for you on the higher dosage! That's a very common side effect of Parnate--when I was on it, I literally couldn't sleep hardly at all, like maybe 1-4 hours at the most. IMO, that combination of meds you take for sleep (Ambien and Klonopin) seem a little redundant because they both work via the same mechanism of action. It might be better to combine one of either Ambien or Klonopin with something like trazodone, low-dose doxepin, or low-dose Seroquel. That way you'd have two pro-sleep mechanisms of action going on simultaneously. But I'm not telling you how to take your medicine by any means! I'm not a professional. Yes, technically it is as dopamine receptor blocker (Latuda and most other atypical antipsychotics), but it also has very potent 5-HT2A antagonism, which disinhibits release of dopamine and norepinephrine (similar to 5-HT2C blockade). It's also a 5-HT1A partial agonist, which causes downstream dopamine release in certain parts of the brain. It also has 5-HT7 antagonism, which is believed to help with depression, circadian rhythm, and cognition (and I think causes disinhibition of serotonin release). So while you are having some dopamine blockade (in the mesolimbin pathway, where there are more D2 receptors), it has serotonin receptor antagonism at 5-HT2A in the mesocortical pathway (where there are more 5-HT2A receptors than D2 receptors). So it releases dopamine where it is needed, and keeps dopamine in control where it's needed too (preventing hypomania, psychosis, etc.) Very glad to hear that! I felt the same way about it myself. That's great! I hope it keeps up for you! Keep us posted on how you're doing! 🙂
  6. Good luck! 🙂 Hope your doc is able to give you something that helps.
  7. 200 mg is the max dose for sleep, because after that, the blood levels of the active metabolite, mCPP, raise to a level where the medication actually becomes stimulating rather than sedating. 300-400 mg, as @ladysmurf said, are for depression outpatients, and 600 mg is the maximum dose used for depression inpatients. That's a lot of trazodone! 😮 If you have developed a "tolerance" to this med, which often happens to many people, including myself, you may wish to discuss a different sleeping med with your doctor... Something like low-dose Seroquel (25-50 mg), low-dose doxepin (10 mg)/Silenor (3-6 mg), low-dose Remeron (7.5-15 mg), Belsomra, Rozerem, Atarax/Vistaril, Saphris (if your insurance will let you get it without step therapy), Ambien/Ambien CR/Zolpimist/Edluar, Lunesta, ProSom, Halcion, Restoril, Ativan, Serax, Dalmane, Doral, gabapentin, etc. Heck, even low-dose Thorazine will definitely get the job done! (25-100 mg) Just watch for acute dystonic reaction to Thorazine... it happened to me my first time taking it (I took half a 100 mg tablet), but never again thereafter. Seroquel and Saphris are atypical antipsychotic, newer than the typical antipsychotic Thorazine. A word about Saphris, it is sublingual only, and tastes awful. They try to add some cherry flavoring in there, so it tastes like a disappointing cherry liquor... lol Doxepin (Sinequan) is a tricyclic antidepressant, but at low doses and even microdoses (Silenor), it acts as one of the most potent antihistamines and puts you to sleep. Remeron is a NaSSA (Noradrenergic and specific serotonergic antidepressant) and is, I believe, the most potent antihistamine on the market, but it will definitely put some weight on you and increase your appetite--some people need that, some don't. Rozerem is a melatonin receptor agonist at MT1 and MT2 receptors, but one could arguably just take melatonin (low dose) and get the same effect. Belsomra is an orexin receptor antagonist. Orexin is responsible for wakefulness, vigilance, feeding behavior, and energy expenditure. Antagonizing the receptors (blocking them) keeps orexin from making us want to stay awake more. It's a pretty good medicine, I must admit (when it works, it's a little hit or miss for me). You have to titrate up to your dose though, whereas some doctors and pdocs just prescribe the max dose of 20 mg right off the bat. Atarax and Vistaril are the same medicine (hydroxyzine), except the Atarax is "hydrochloride" and VIstaril is "pamoate," the latter of which permeates the central nervous system more easily and can thus help you with anxiety and insomnia, however you take it. The pamoate is a capsule though (Vistaril), so it can't be split if you discover 25 mg or 50 mg is too high a dose for you. Ambien is zolpidem, a nonbenzodiazepine or "Z-drug." It has some variations out there, including Ambien CR (controlled release), Zolpimist (oral spray, tastes worse than Saphris!), and Edluar (orally disintegrating tablets). Lunesta is another Z-drug, but it lasts a little longer than Ambien and probably even Ambien CR. Definitely lasts longer than Sonata (which I didn't include because it only works for sleep induction, not sleep maintenance, but if that's all you need, I'd recommend Sonata actually. It worked far better for me than Ambien.) Halcion and Serax are short-acting benzodiazepines; ProSom, Restoril, and Ativan are intermediate-acting benzodiazepines; and Doral and Dalmane are long-acting benzodiazepines. You could throw Klonopin in there too for a long-acting one. It's generally better to stay away from the long-acting ones for sleep as you may likely experience next-day sedation (hangover). Gabapentin (Neurontin) is an anticonvulsant that has pro-sleep properties. It doesn't necessarily make you go to sleep, it kind of "lets" you fall asleep. It may be good as an adjunct medicine to your sleep medicine. It promotes slow wave sleep if I recall correctly. I hope this list is of some help to you, and if not you, then somebody! lol 🙂
  8. Parnate can take anywhere from just one day to several weeks to work depending on the person. It's really a miracle med for those for whom it works! Parnate pulled me out of a deep, bottomless void one winter a few years ago. I was also taking it with Adderall (which is classically contraindicated, but can be done under close supervision of your pdoc and with a blood pressure cuff to watch your blood pressure), Abilify (I think?), Mirapex, and some other stuff. The Mirapex made me eat compulsively so I stopped it, but remained on Parnate 20 mg and Adderall 30 mg for months and felt relief that didn't poop out like all the other meds had for me. The only problem with Parnate for me was that it made me gain 50 lb in 3 months which is very paradoxical because it's supposed to cause weight loss. My pdoc upped my Parnate to 40 mg and took away the Adderall and I completely crashed though... Not sure if it was stimulant withdrawal, too high a dose of Parnate, or both... But don't let my experience scare you though. Hang in there with the Parnate, it'll eventually get to working, I hope. You'll definitely know when it starts kicking in! However, some people just don't feel the effects of MAOIs, which is unfortunate. But let's hope you're not in that minority of population. Best of luck with the Parnate! Keep us updated! 🙂
  9. Oh, I see. Very sorry to here that. I didn't realize that's how things were in the UK regarding psychiatrists. That's definitely something to note if I chose to move to another country... lol. You're welcome, and thank you! Oh no, I'm sorry to hear that. 😞 Hopefully the seroquel is working in your favor. I just suggested those because they're more "metabolically friendly" medicines: less weight gain, less chance of diabetes, less increases in cholesterol, etc. In my personal experience, Abilify was my brain glue, but it unfortunately came with a nasty side effect of compulsive buying due to being a dopamine partial agonist. I'm currently in the process of switching to Vraylar, and I feel brighter, lighter, livelier, and feel like actually interacting with people. But I have to go down on the Abilify slowly because otherwise I'll lose my mind! lol They probably won't do too much for anxiety, but then again, everyone is different. Personally, Abilify in low doses was so stimulating it made me hypomanic, and high doses were physically stimulating, almost like taking a stimulant (which I do take, but it felt like it augmented the effects of them). No anxiety resulted from Abilify. Vraylar is kind of the same was as Abilify, but different in some ways. It's really hard to put my finger on it, but it's nice too.
  10. That's BS that your pdoc won't refer you to a pdoc. If he isn't treating you properly with medications, you have every right to have a recommendation to a pdoc. You're right in that Seroquel doesn't become an antidepressant until 150-300 mg, where it begins to robustly inhibit reuptake of norepinephrine. There's no real worry about it canceling out the effects of serotonin and dopamine. Its dopamine antagonism is very weak compared to other antipsychotics (800 mg is where it really blocks dopamine). The serotonin antagonism is actually a good thing. Blocking the 5-HT2A and 5-HT2C receptors causes increased dopamine and norepinephrine release--it "cuts the brake line" so to speak for the release of those neurotransmitters. Also, it has 5-HT1A partial agonism which helps with anxiety and depression, as well as helps negate EPS. The only things about Seroquel and its active metabolite are that they are a potent antihistamine and anticholinergic, the former of which can cause weight gain, the latter of which can increase chances of dementia (supposedly) as well as diabetes. Do you have a lot of anxiety? That may be why your doc put you on such a low dose and won't raise it, because he's probably trying to use it as a substitute for a benzo, which is ridiculous in my opinion. If you don't have a lot of baseline anxiety, I would recommend giving Abilify or even Vraylar a trial (if your insurance covers it) instead of Seroquel XR. Vraylar has a copay coupon that gives you the first fill for free and the rest for as little as $15 depending on how much your insurance wants to charge for it.
  11. Many apologies for saying that about your mother. She must have some idea of what the medicines do, but still, I would listen to your prescriber. I hate it when doctors just disappear off the face of the earth like that... It makes it very hard on both you and the new doctor to pick up where they left off. Hey, it's not stupid! It's your mental health. You need to do what you need to do about it. If that means admitting you've relapsed, well, I see no shame in that--it means you have insight into your illness and that you know what you need to fix it, which is not something many people can say about themselves.
  12. You need to take antidepressants until your doctor tells you to stop. If I'm guessing correctly, your mother is probably not a doctor. I would definitely start taking the Lexapro again before your episode goes to a full blown major depressive episode again.
  13. Abilify tends to be one of the more weight-neutral antipsychotics, but for some unlucky few people, they either experience weight gain and/or difficulty losing weight. If you continue to experience weight gain, you could probably ask to try one of the other atypical antipsychotics that are more weight-neutral, like Vraylar or Latuda.
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