Thanks for your response! I've been on Wellbutrin for over 3 years. I started the Lexapro because work stress was becoming too much and I lost all motivation and was very apathetic. Wellbutrin was the best antidepressant I had tried (Effexor, Celexa, Prozac). I'm going to ask about weening off on my next appointment next week. The school year is almost over and the cons are outweighing the pros for me. Although I've gotten my motivation back, I cannot lose weight despite hitting my 10K step goal 6 out of 7 days a week and staying under my calorie goal. I've used MyFitnessPal for over a year and lost 25 lbs, then got lazy/lost motivation, and put 10 lbs back on. I use a food scale to weigh, so I know I'm being accurate. In the last month I've managed to lose 0.4 lbs. Although I don't have a lot of weight to lose, losing it is still a big deal to me.