Yeah, I have read about taking it on an empty stomach and not to take it with SJW due to that risk. What I've read, serotonin and dopamine don't readily cross the blood-brain barrier. So, a good amount of it that the body produces from these supplements stays in the blood stream. There are several co-factors involved in the synthesis of serotonin and dopamine from 5-HTP and Tyrosine that are necessary for optimal production. Co-factors are Vitamin C, Vitamin B6, Calcium, Cysteine, Selenium, and Folic Acid. However, I really don't want to be taking all those pills every day, so I will try to supply these co-factors with my diet. I'm a pescetarian, so the only animal products I eat are from sea foods, eggs, and dairy. I'm searching on Amazon for 5-HTP and Tyrosine. If I end up buying them I will post about how it's affecting me.