Zoloft worked wonders for me at 50mg and 100 mg, for both depression and anxiety. I upped the dose to 100 mg when I was going through a life changing situation and it did help. Zoloft made me tired about 4 hours after taking it, so I started taking it in the evening and that worked. By taking it in the evening it also seem to help with the occasional insomnia, one of the possible side effects of Zoloft. After many years, it didn't feel like it was working, but probably was. I switched to Celaxa anyway, which seemed to work for depression but didn't work as well with anxiety. I stuck with it because I did not want to keep switching medicine, but I am going back on Zoloft or trying Lexapro. I've had anxiety and social anxiety since I was young, and Zoloft helped 100% with socal anxiety. A side note, I did succesfully ween off of Celexa for two years without any issues, so some people can go off anti-depressants. When I started a new job, which was stressful in itself, and had to drive through my old stomping grounds, it brought back memories. This sent me into a mild depression, where I would cry over everything with bad anxiety, so I went back on.