I've been on duloxetine/cymbalta for anxiety and panic attacks caused by micromanaging at work (unfortunately this is acceptable at work, but that's life !) I could clearly remember the first time I took cymbalta 30mg, everything seems ok until 2 hrs later it struck me whilst I was shopping, I felt heavy chested almost choking sensation it was very difficult to breath, I had to rush home and curl up in bed, I was then extremely relaxed so much so I couldn't really move and soon fell a sleep in the afternoon. After 2 weeks my doctor up my medication to 60mg, I felt really good almost a sense of euphoria, a medical high and cymbalta was the best thing that happened to me. I started to take cymbalta in the mornings as it was affecting my sleep if I took it a night due to the electrical zaps i get bit different from brain zaps. A few months later (and a few more panic attacks) the panics attacks stopped or was not so severe, I missed my medication at work and this is when everything good about cymbalta ended. I missed a tablet 60 mg one day and my heart was beating so fast 130 bpm for 4 days non stop even when resting, although I didn't feel like I was unwell, I went to see my doctor and she quickly advise me to do a EGC scan and I nearly had to be admitted to hospital. I then was told to go down to 30mg which was torture for 1 month due the withdrawal symptoms, and then asked to go back to 60mg. Everything was ok, my emotions was very numb, I wasn't sad or happy just very dull. During this time i had been seeing a psychologist and I was very confused about my emotions I had a big personality and cymbalta kind of took away my personality and I felt not myself. I was sedated, feeling unintelligent, I wasn't speaking confidently, i would slur my words due to the mouth grinding side effect that comes with cymbalta. In fact I had a lot of side effects including blur vision, craving for lots of sugar, weight gain, mouth grinding, fatigue, diarrhea, stomach cramps, slight feeling like i'm about to faint, restless legs at night, brain zaps, thirsty, flu like symptoms, diabetes like symptoms, confusion, zoning out, rapid heart beats at times. I also had constipation and the toliet would be full of blood almost everyday for a few months (this may not be a symptom but constipation stopped after cymbalta) . These symptoms stuck with me through out the rest of time with cymbalta. The only thing that got worst was fatigue, I would wake up every morning almost all the time at around 5am and I can easily get out of bed ok, but when I went back to sleep and my alarm went off at 9am I was so knocked out and drowsy that I couldn't move at all almost felt like I was tranquilized, I never felt so fatigue, and if I tried to wake up I couldn't stand up properly and most of the time I had to call work to take a day off. This was happening to me about twice a week. If I gave in and slept, I would sleep upto 15 to 17 hours and on weekends I would sleep most of the afternoon and I would also have no trouble sleeping at night as well. When I do manage to drag myself to work I must confess that I need coffee, and I would have 1 to 2 cups a day which didn't effect my sleep at all. I do have weird dreams, and have excessive sweats when i wake up in the morning, my bed sheets would be soaking wet, and I'm not sure if my excessive sugary diet was playing a factor in the amount of sweats. Fatigue got so bad that I would take alot of time off work as I was so knocked out, this is very different to being sleepy and can't wake up, this was seriously like being knocked out when your knocked out from bringe drinking without the spinning and nausea, I felt like i didn't want to move and if I did wake up I couldn't stand up straight and I couldn't really walk. This led to HR question me at work for taking too much sick leave without certificate and it was so hard to explain and even though I have explained my condition already. Work was pressuring me to come in on time and each time I had to explain that I was very fatigue and I believe this had to do with my medication. I decided to withdraw from cymbalta, due to all the side effects directly or indirectly caused by cymbalta, I went cold turkey against my GP's orders to withdraw slowly and took time off. To be honest it wasn't too bad in comparison to all the symptoms i had, there was alot of brain zaps and this continued for a month after the withdraw process. During my withdrawal of Cymbalta/cold turkey, I had anxiety symptoms, felt grumpy, felt like i haven't slept properly, 1 or 2 weeks after my withdraw, during my shopping I would walk around the shopping with no clear direction of where I'm going, I would sweat alot suddenly my heart beat would be around 120 bpm or higher, my legs would suddenly feel wobbly and a sense of feeling unwell needing to lie down. My emotions was like a rollercoaster, almost split personalities, I would feel very confident, feel like spending money and shopping then I would feel flat but defensive and assert myself strongly, then later there is another kind side of me which I spoke softly and very kind. Slowly these polar sides of my personality is slowly balancing out, but it's a scary thought to think that what started out with panic attacks and anxiety end up like this. I'm not sure if anyone had a similar situation as myself with cymbalta ?