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Farshad

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  1. So Mirtazapine and wellbutrin is a well known combo.. But I looked into the Pharmacology OF both Mianserin and mirtazapine and based on the Pharmacology the Mianserin seems better - I asked on another forum and a guy said this : ''Mianserin acts on alpha receptors but as an antagonist meaning it blocks the binding of NE to alpha-1 (and hence its "activation") and by blocking alpha-2 (a presynaptic autoreceptor) it increases the release of NE into the synapse by the presynaptic neuron. Inhibition of NET also prevents the reuptake of NE into the presynaptic neuron so the increased amounts of NE being released isn't being reabsorbed and is free to then act on the alpha-adrenergic receptors (that haven't already been occupied by the Mianserin) and on the beta-adrenergic receptors.Mirtazepine does not inhibit NET, therefore reuptake, so NE is free to be reabsorbed from the synapse into the presynaptic neuron. It also does not antagonise alpha-1 so NE is free to activate this receptor as it usually would. Antagonism at alpha-2 again increases the release of NE into the synapse.So in summary seems to me Mianserin would have the most net increase of adrenergic neurotransmission. There's many other mechanisms of action at play here though so it's hard to call one superior to the other - that is subjective.'' So basically mianserin is better even tho he wont admit it.. So I wonder why Mianserin + wellbutrin isnt well known? I believe they made mirtazapine just so the patent would last and they could make more money even tho its weaker than mianserin.. So I wanna Start Mianserin + wellbutrin soon? Anyone been on this combo or Mirtazapine + wellbutrin? since mianserin and mirtazapine are pretty similar but mianserin is better as explained above.. I also wanna add low dosage Abilify to the mix .. So any opinions are welcome . my dream combo would be Mianserin + wellbutrin + abilify and maybe I will try mirtazapine to see if I like it better than mianserin ...Anyhow.. Any experiences with Mirtazapine + wellbutrin or mianserin + wellbutrin ? :D I have a few questions about mianserin or mirtazapine? 1. do they make you tired? 2. do they make you gain weight? if yes how much? 3. what other side effects did you encounter?
  2. Farshad

    High Serotonin Levels

    Social anxiety disorder linked to high serotonin levelshttps://jamanetwork.com/journals/jam...stract/2319710higher serotonin means lower dopamine.Blood samples from infants who died of Sudden Infant Death Syndrome (SIDS) had high levels of serotonin.http://neurosciencenews.com/serotonin-sids-7023/http://www.parentherald.com/articles...m-disorder.htm"...Another thing the study found out is the relationship of serotonin to ASD. The results show that about 30 percent of the total number of the correspondents, which are children having the disorder, have hyperserotonemia. When they have undergone tests, their blood exam showed they are positive to have an above normal level of serotonin. With the information gathered, Cascio and her group became certain of how hyperserotonemia affects people with ASD. And to know more about it, she said that the group is currently working to prove their hypothesis, which she believes will be a stable ground for future research."There's a theory about serotonin being boosted when the body is under stress because of an increase in an enzyme that turns tryptophan into serotonin.Injection of serotonin to rats decreased brain ATP levels. https://www.ncbi.nlm.nih.gov/pubmed/7875554Of course I assume many of you have seen the articles on a few different sites about how high serotonin brain concentration have been linked to higher social anxiety.Antagonists of a certain serotonin receptor have been shown to reverse helpless behavior in mice. https://www.ncbi.nlm.nih.gov/pubmed/1532555https://www.ncbi.nlm.nih.gov/pubmed/7991722decrease serotonin in our brain and have less social anxiety (good), less "learned helplessness" (good), and less inhibition (let's face it, for most of us that's good).Tryptophan, serotonin, and aginghttp://raypeat.com/articles/aging/tr...in-aging.shtmlSerotonin, depression, and aggression: The problem of brain energyhttp://raypeat.com/articles/articles...gression.shtmlI came across this study https://www.ncbi.nlm.nih.gov/pubmed/5064914 If benzo work for anxiety by reducing serotonin why are we getting prescribed ssris?Serotonin may not be a major factor in depressionhttps://www.reddit.com/r/depression/...in_depression/Serotonin has a bunch of downstream effects in the brain. Serotonin decreases orexin.fenclonine & AGN-2979 are the only 2 drugs that deplet serotonin . Serotonin antagonists like cyproheptadine just block serotonin from having an effect it doesent actually reduce the levels of serotonin in the brain, so they dont work. So why do people still think serotonin is so good? why does everyone wanna raise it? I WANNA deplet mine... High serotonin is a curse.
  3. Farshad

    Effexor vs Cymbalta

    dunno but i tried a high dose of effexor over the max dose recomennded for over a week maybe 2 weeks didnt do anything for me .
  4. Hello has this combination worked for anyone? I am starting wellbutrin 300mg and 5mg abilify soon for depression and social anxiety,adhd and I was wondering if anyone has found relief from this combo?....
  5. Hello has this combination worked for anyone? I am starting wellbutrin 300mg and 5mg abilify soon for depression and social anxiety,adhd and I was wondering if anyone has found relief from this combo?
  6. hey im gonna ask for these on my next appointment. how was your experience with these? I need something for my depression and social anxiety. Some say wellbutrin is very good for depression and some say its bad for anxiety but other say its good for anxiety. And buspar some say it works for anxiety other say its a sugar pilll... How was ur experience? I wanna combine these.
  7. yeah try the regular one it acts faster if you're just gonna use for sleep.
  8. it might in the beginning but that can go away it also depends on the person and your dosage.
  9. bump so others can see .
  10. Hey... Anyone have experience with this TCA medication? Im looking to cure these problems of mines -OCD -Depression -Social Anxiety From Wikipedia, the free encyclopedia Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).[2] It is used for the treatment of obsessive compulsive disorder, panic disorder, major depressive disorder, and chronic pain. It may decrease the risk of suicide in those over the age of 65. It is taken by mouth.[2] Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. Serious side effects include an increased risk of suicidal behavior in those under the age of 25, seizures, mania, and liver problems. If stopped suddenly a withdrawal syndrome may occur with headaches, sweating, and dizziness. It is unclear if it is safe for use in pregnancy. Its mechanism of action is not entirely clear but is believed to involve increased levels of serotonin.[2] Clomipramine was discovered in 1964 by the Swiss drug manufacturer Ciba-Geigy.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[4] It is available as a generic medication.[2] The wholesale price in the developing world is between 0.11 and 0.21 per day as of 2014.[5] In the United States a typical dose costs about 1.20 USD per day.[2] It was made from imipramine.[3]
  11. did those that had luck with emsam also try nardil or parnate and it failed with them?
  12. nop nardil only. im gonna go trough all the maois eventually if i can. u should try nardil it might work for u who knows, anyway im trying parnate first than i guess emsam or any other maoi if i think there is a better option than emsam first.
  13. which one had better effect would u say? parnate or nardil? or were both sh1t. or did u only try nardil?
  14. if you got any questions feel free to ask.
  15. tell him to try an MAOI
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