Jump to content


Junior Member
  • Content Count

  • Joined

  • Last visited

About MiaouMikse

  • Rank

Profile Information

  • Gender
  • Interests
    Not being depressed, arguing with medical professionals

Recent Profile Visitors

413 profile views
  1. ^that's why we have Modafinil. Little bit different mechanism of action, but some people compare it to classic stimulants.
  2. ^I'm in the US and interested in the Tianeptine. Can I get a local doctor to at least monitor me while on it it, or will it be "endorsing bad choices" on his part? I mean, if I was, say, abusing alcohol, the doctor would still see me but tell me to do it less often (but not zero...so it is a harm minimization thing).
  3. NoThisIsPatrick, I'm very liberal when it comes to medical used of otherwise "street" drugs, but MDMA will undoubtedly make it worse long term. You can expect negative brain changes from a single use. When you force a release of dopamine/serotonin, etc, your receptors will downregulate causing even more lowered activity of those transmitters. MDMA forces a release of neurotransmitters (plus inhibits reuptake) from even the intracellular stores (the emergency backup) so yes, the feedback effect would be disastrous. If you want more action at X receptor, you shouldn't hit the receptor directly. Chances are there is process Y that was inhibiting it, so you hit Y, thus freeing up X indirectly. A "street" drug that DOES show promise is Ketamine. A weekly treatment gives you long lasting improvement. Too bad
  4. Re options: Brandoonee, I checked and sadly, Tuaneptine does not seem to be available in the UK. It is not a scheduled drug though, so I imagine it wouldn't carry terrible penalties if caught. It should be available in France, since they invented the stuff. Memantine should be available anywhere, but since its is an "Alzhemier's drug" not an "antidepressant" I imagine you'd have trouble convincing a doctor, especially since your UK health system is so very uptight on these things (and I thought America was bad...) Selegiline is a standard (but older) antidepressant drug. Do get the transdermal version to minimize side effects and drug interactions though. I found a patient handout on your NHS UK site, so it looks like you're good. Ketamine is legal as an anesthetic. Not sure of its UK use in depression, I couldn't find a single government patient info page. Elsewhere, is seen as a "last resort" treatment (which is weird, given that it is really, really safe and effective) and so would be problematic. Don't try this on your own though! It really does need medical supervision as it is an inpatient treatment. They give you a weekly dose that makes you confused and disoriented for a short time. The benefit is from when it wears off, actually.
  5. ^I think so as it is more favored in Europe, but if it isn't, don't let that stop you if it is your last resort and you are suicidal or anything. Anhedonia is an excellent predictor of suicide. I know it is not available in the USA. Bummer, because it seems like an excellent drug. It is basically the opposite of an SSRI in that it LOWERS your serotonin. If you think it will cause anxiety, it won't; it is marketed especially against anxiety as well. There is about a zero chance of this causing anhedonia, unlike SSRIs. From some interesting downstream regulatory effects, you end up with UP regulated dopamine, neuroplasticity factors, and opioid signalling (opioid signaling is what gives you a mood boost from heavy exercise). It is not addictive, does not have withdrawal effects, and has minimal general side-effects. SSRIs probably only work (and only for some people) from their downregulatory effects on the biology of stress, not the "increasing serotonin". Tianeptine addresses HPA axis dysfunction just as well. Bonus points is it kicks in very quickly, in the first week or two. Option 2 is Selegiline, a special kind of MAOI that shouldn't have dietary restrictions (especially if taken transdermally). This is more symptomatic as I can't see how it would address any fundamental depression biology. I'm really not a fan of the monoamine hypothesis, as you can see. If that isn't an option, you might be able to get Memantine off-label. It is a NMDAr antagonist and should work vaguely like Ketamine (the nuclear bomb against anhedonia). It's downstream effect is also to upregulate dopamine and neuroplasticity which is why it is originally given for symptomatic treatment of Alzheimers. Speaking of Ketamine, do they do that in the UK? Good luck.
  6. Anhedonia is a VERY strong predictor of suicide. You can't really feel the seriousness of your actions since you don't feel anything. http://nadorff.psychology.msstate.edu/winer.etal.psy.res.inpress.pdf
  7. Try exercising VERY HARD. Heart rate 180+ for a few mins (if medically safe). You could give yourself a few-second long window of normalcy right there on the first trial. This information could then guide your treatment decisions. I'm personally wary of the SSRIs as they can worsen it (or help), but I'd rather try something that has almost zero chance of worsening it. It's really the worst feeling ever, I miss the days when I could have a bad thought. At least it is a reaction of some kind.
  8. (oh, and please don't stick your face in something highly scented! You need oxygen, too, not just flower particles) haha. I suppose getting high via inhalant abuse is NOT the goal of this.
  9. I sense a possible Proust effect here. I don't believe in the mystical stuff though. Smell is powerfully ingrained in emotional memories. If you can't access the happy memory of, say, Christmas time at your family home directly, then smelling something that would have been present (pine trees, cookies, etc) can bring up that memory (and it's emotion) out more vividly. Perhaps the essential oils simply remind you of nice things then (which doesn't mean it doesn't work as a therapy, just not via "ayurveda') I know for sure that the smell of lavender reminds me of my granny's home (she used it as some kind of insect repellant) which is the one place I was safe from my insane narcissist father. It makes me happy to smell it again.
  10. I force myself to watch MORE porn. I'll actually pause and rewind it if I thought I zoned out. Sometimes I can get vague traces of sexual feelings back this way. I can't image why an anhedonic person would further deny themselves something that can produce pleasure! Yes, porn can be (psychologically) addictive BECAUSE it provides pleasure. I doubt there is a biological addiction as with drugs. People turn to it in search of that pleasure when they have blunted pleasure elsewhere in life. They're kind of self-medicating and it's sure better than starting actually harmful drugs! They only pay in social isolation and distraction I guess, which beats, say, health effects of smoking crack. However, if joining the "no fap" bandwagon gets you outside your porn-computer and out interacting with humans and doing productive things, that can probably help the depression. However, you can see it is not because of the porn per se, just the isolation needed to watch it compulsively. It's probably part of a wider pattern of sensation-seeking, which, again, is a symptom of depression.
  11. My having imagined myself cured, fully functional, and pointing my finger in the face of all the "a pill will never help you, you need to not be lazy and stupid" types I seem so surrounded by! BWAHAHAHAHAH magic pills floating in my blood shall slay your doubts. Supermanwoman mode: engage
  12. How bad can your lack of concentration, working memory, spatial awareness, verbal reasoning, etc, get from the depression alone (not side effect of drug)? I'm not distracted by bad thoughts/ anxiety/ anything. My mind is just blank and nonfunctional. I have the anhedonia. I'm about halfway recovered and still need to print out 2 separate sets of directions for going and returning BY THE SAME ROUTE. I cannot mentally reverse the order of turns I made. I can read a whole 300pg book and then not remember the main character's name. Of course, usually I cannot finish the book because I can't concentrate. Does it get better? It's just so bad It seems like nothing outside of Alzheimer's can cause it (I don't actually think I have it...just metaphor) . The term "Mood disorder" seems so trivial of a name for something with such debilitating symptoms!
  • Create New...