My whole Regimen was changed recently. I was on remeron, zoloft 50 mg and klonopin. Now I'm on pristiq 50 mg, trazodone(for sleep) and klonopin. Anyways, let me get back to the topic. I'm noticing some mild antidepressant effect on pristiq after only 1.5 week and as far as the sexual sides go, my main dilema with all the ssri's and snri's that I been on, (which has been all of them) has been not being able to orgasm on them and decrease libido second. I'm happy to say that so far on 50 mg of pristiq, I only have mild delayed ejaculation and compare to a low dosage of 50 mg of zoloft, the difference is alot. I'm so happy about this because my main reason for switching from ssri's and snri's has been because of the sexual side effect and now I can live with pristiq as far as the sexual side goes. Hopefully after sometime things are going to even get better as far as my sexual life on pristiq. I just hope that now pristiq antidepressant and anxiety effect will be just as good.