Hi, everyone I'm new to the anhedonia subject, but I'm fighting for more than 10 years against many of the symptoms that are listed in this thread as associated to this condition. To organize my first post, I'm separating it into topics, as follows. Here follows a brief historic of mine: When I was about to complete 18 years, I developed panic syndrome. Fortunately, after I found a good psychological treatment, the panic symptoms almost stopped, however many others emerged: 01. Emotional "flatness" or sense of feeling nothing. Rare of being happy or sad. 02. "Very low" sex drive 03. Inability to love, to fall in love or to feel passion. 04. Binge eating at bed time 05. Hard to laugh at funny things 06. Sense of no purpose in life 07. Constant irritability and bad mood 08. Very hard to focus when studing. 09. Difficulty in memorizing things 10. Porn addiction Those sensations and feelings are the very oposite of those I had in my so beloved adolescence. Thus, since my early twenties, I've reading about neuroscience, brain chemestry, psycology, psychiatry, orthomolecular, hormonal replacement therapy, and many other topics. I guess also had problems with pornography, since, according to some recent findings, firing dopamine excessively downregulates reward circuitry, due to Delta-FosB protein action. Here is what I would like to discuss: Now, I friend of mine related me that he had great success on his long date depression using low-dose naltrexone (LDN) and low-dose selegiline (LDS). Although all articles and reviews about naltrexone show excelent results, I'm not convinced about selegiline, since raising dopamine seems to inherently cause downregulation on its receptors, what leads to tolerance, thus long term use problems. Since opiate addiction could lead to low sex drive, LDN seems to be a valuable aid in this issue. Thus, had anyone here tried naltrexone? In relation to dopamine system, does anyone here ever tried to use selegiline at low doses (1 to 5mg)? Some extra points: A. I'm now on an Ericksonian therapist, which is helping me to cope with some problems, but I feel it is not bringing me to my "normal". B. Now I understand that I have also "enviromental" problems. Because when I was young I barely stayed at home and I perceived that the more I become recluse, the more symptoms strengthen. C. I'm a 31 years brazilian man and straight. D. I'm sorry for the long post Best regards.