I was on Valdoxan for a year. Initially, I had nightmares and kept waking up every 1-2 hrs overnight however this eventually settled and I just had vivid dreams (this seemed to coincide with increasing my dosage from 25mg to 50mg). Within the first week I felt happier and less anxious and I thought I had FINALLY found THE miracle drug. However, over the next few months I started to experience migraines regularly and didn't have 1 day where I was headache free. My liver enzymes went up and I felt very fatigued - I slept half the day away. I reduced from 50mg to 25mg but the migraines persisted so I have now discontinued the drug. This is the first drug (of many!) where I actually felt some positive changes to my mood and anxiety but due to the side effects I had to stop. The last few weeks since coming off have been awful :( My mood is low and i'm extremely irritable.