Modest cognitive benefit with
antipsychotics in schizophrenia
July 06 2010
MedWire News: Schizophrenia patients treated with
antipsychotics over a 2-year period show modest improvement in
cognitive test performance, study results show.
to prevailing opinion, there was no difference
between conventional and atypical psychotics in cognitive
improvement, and the researchers say that a decision to switch to
the latter medication should not be taken solely based on
"Atypical antipsychotics provide better control of the
and affective symptoms of schizophrenia when compared with
conventional neuroleptics; nevertheless, their heightened ability
to improve cognitive dysfunction remains a matter of debate," write
Gabriel Selva-Vera (University of Valencia, Spain) and colleagues
in the journal BMC Psychiatry.
In the current study, the
researchers recruited a sample of
schizophrenia patients taking either conventional (n=13) or
atypical antipsychotics (n=26). They performed a battery of
neuropsychological at baseline and at 2 years of follow-up.