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Wellbutrin + Abilify

wellbutrin abilify combo

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9 replies to this topic

#1 floorguy

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Posted 20 January 2012 - 04:07 AM

Hi,

do you know if these two can be taken together? Abilify is metabolized by CYP 2D6, while Wellbutrin inhibits that enzyme.

Thanks.

Edited by floorguy, 20 January 2012 - 04:08 AM.

MDD - recurrent and treatment-resistant, GAD, Social phobia (somewhat under control with clonazepam)

Current meds: mirtazapine 45mg, nortriptyline 150mg, clonazepam 2mg

Previous meds: abilify, zyprexa, seroquel, sertraline, fluoxetine, paroxetine, venlafaxine, milnacipran, reboxetine, bupropion,
nortriptyline, clomipramine, trimipramine, T3, lithium, modafinil, lamotrigine, buspirone, diazepam,
oxazepam, temazepam, chlordiazepoxide, zopiclone, zolpidem

#2 LaurynJcat

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Posted 20 January 2012 - 08:36 AM

Hi floorguy,

I'm not a medical professional and have never tried this combo.  A quick Internet search reveals there is a drug interaction between Wellbutrin and Abilify.  But also that many people take them together without a problem.  Here's what one site said:

Abilify (aripiprazole) and Wellbutrin (bupropion) can be used together, except they both can lower the threshold for having a seizure. The interaction is minor, unless you have a history of seizures, in which case, you should let your doctor know.

Hope that helps.  There may be people on DF who take this combo and hopefully they will speak up to say how it works for them.

Cheers,
Lauryn
"Be gentle with yourself. You are a child of the universe, no less than the trees and the stars;
you have a right to be here."


- excerpt from Desiderata by Max Ehrmann
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#3 Bleedingheart

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Posted 20 January 2012 - 12:19 PM

Hi Floorguy,

I've been taking wellbutrin and abilify for years and it's worked out well. I have never had any seizures in my life but my Psychiatrist told me not to quit it cold turkey as it increases chances of seizures. Always take as directed and follow up with all Dr appts. You may want to talk this out more with your Dr .

I'm one sucess case if your loooking for that kind of support. Good luck

Bleedingheart

#4 lindahurt

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Posted 20 January 2012 - 10:20 PM

Hello floorguy,

I'm currently taking 300XL of Wellbutrin and now 5mgs of Abilify.  I see my doctor on a regular basis and haven't had problems with seizures.  My doctor think its a good mix for my depressive episodes.

Lindahurt

Even in the most horrific of situations, one's attitude has an enormous role in shaping what happens ~ Viktor Frankl
In you lies the power to choose, to commit  - Stephen Convey


The kind of person you want to become is greatly influence by your inner decisions, and not from outside influence alone.  We can even under adverse circumstances, decide what shall become of us ~ Brian C. Stiller



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#5 floorguy

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Posted 21 January 2012 - 06:50 AM

View PostBleedingheart, on 20 January 2012 - 12:19 PM, said:

Hi Floorguy,

I've been taking wellbutrin and abilify for years and it's worked out well. I have never had any seizures in my life but my Psychiatrist told me not to quit it cold turkey as it increases chances of seizures. Always take as directed and follow up with all Dr appts. You may want to talk this out more with your Dr .

I'm one sucess case if your loooking for that kind of support. Good luck

Bleedingheart

What doses of Abilify and Wellbutrin are you on?

Thank you.
MDD - recurrent and treatment-resistant, GAD, Social phobia (somewhat under control with clonazepam)

Current meds: mirtazapine 45mg, nortriptyline 150mg, clonazepam 2mg

Previous meds: abilify, zyprexa, seroquel, sertraline, fluoxetine, paroxetine, venlafaxine, milnacipran, reboxetine, bupropion,
nortriptyline, clomipramine, trimipramine, T3, lithium, modafinil, lamotrigine, buspirone, diazepam,
oxazepam, temazepam, chlordiazepoxide, zopiclone, zolpidem

#6 floorguy

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Posted 21 January 2012 - 06:51 AM

View Postlindahurt, on 20 January 2012 - 10:20 PM, said:

Hello floorguy,

I'm currently taking 300XL of Wellbutrin and now 5mgs of Abilify.  I see my doctor on a regular basis and haven't had problems with seizures.  My doctor think its a good mix for my depressive episodes.

Lindahurt

Does it work well for your depression?

Thanks.
MDD - recurrent and treatment-resistant, GAD, Social phobia (somewhat under control with clonazepam)

Current meds: mirtazapine 45mg, nortriptyline 150mg, clonazepam 2mg

Previous meds: abilify, zyprexa, seroquel, sertraline, fluoxetine, paroxetine, venlafaxine, milnacipran, reboxetine, bupropion,
nortriptyline, clomipramine, trimipramine, T3, lithium, modafinil, lamotrigine, buspirone, diazepam,
oxazepam, temazepam, chlordiazepoxide, zopiclone, zolpidem

#7 floorguy

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Posted 21 January 2012 - 06:52 AM

Thanks guys for your input, really appreciate it!
MDD - recurrent and treatment-resistant, GAD, Social phobia (somewhat under control with clonazepam)

Current meds: mirtazapine 45mg, nortriptyline 150mg, clonazepam 2mg

Previous meds: abilify, zyprexa, seroquel, sertraline, fluoxetine, paroxetine, venlafaxine, milnacipran, reboxetine, bupropion,
nortriptyline, clomipramine, trimipramine, T3, lithium, modafinil, lamotrigine, buspirone, diazepam,
oxazepam, temazepam, chlordiazepoxide, zopiclone, zolpidem

#8 lindahurt

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Posted 21 January 2012 - 07:21 AM

View Postfloorguy, on 21 January 2012 - 06:51 AM, said:

View Postlindahurt, on 20 January 2012 - 10:20 PM, said:

Hello floorguy,

I'm currently taking 300XL of Wellbutrin and now 5mgs of Abilify.  I see my doctor on a regular basis and haven't had problems with seizures.  My doctor think its a good mix for my depressive episodes.

Lindahurt

Does it work well for your depression?

Thanks.

Yes, they are working for me.  I'm improving and having good success.  I hope it works out for you too.
Lindahurt

Even in the most horrific of situations, one's attitude has an enormous role in shaping what happens ~ Viktor Frankl
In you lies the power to choose, to commit  - Stephen Convey


The kind of person you want to become is greatly influence by your inner decisions, and not from outside influence alone.  We can even under adverse circumstances, decide what shall become of us ~ Brian C. Stiller



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#9 Bleedingheart

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Posted 21 January 2012 - 12:23 PM

View Postfloorguy, on 21 January 2012 - 06:50 AM, said:

View PostBleedingheart, on 20 January 2012 - 12:19 PM, said:

Hi Floorguy,

I've been taking wellbutrin and abilify for years and it's worked out well. I have never had any seizures in my life but my Psychiatrist told me not to quit it cold turkey as it increases chances of seizures. Always take as directed and follow up with all Dr appts. You may want to talk this out more with your Dr .

I'm one sucess case if your loooking for that kind of support. Good luck

Bleedingheart

What doses of Abilify and Wellbutrin are you on?

Thank you.


I was taking 300mg Wellbutrin and 10mg Abilify,,, was on that for years,, New Doc now so my meds have changed a bit ,take 200 Wellbutrin 10mg Abilify and 40mg Cymbalta. I am feeling almost normal,,if there is such a thing.

Bleedingheart

#10 ladysmurf

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Posted 29 January 2012 - 11:46 AM

View Postlindahurt, on 20 January 2012 - 10:20 PM, said:

Hello floorguy,

I'm currently taking 300XL of Wellbutrin and now 5mgs of Abilify.  I see my doctor on a regular basis and haven't had problems with seizures.  My doctor think its a good mix for my depressive episodes.

Lindahurt

I take the same thing as well. It helps for anxiety, but not for depression. Go figure
Major depression, GAD, OCD, -trying to find my combination for the past 3 years with no luck.





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