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Do Medication Lose Their Effectiness After A Period Of Time


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10 replies to this topic

#1 Wilo77

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Posted 21 August 2011 - 08:16 AM

Hey all,

I am just curious to know if the medication you are put on can lose its effectiveness over time. My friend has been on Cymbalta for a couple of years now and has varied the dose as required. He now has a new drug that he will start tomorrow (not sure what it is) As his depression is so bad at present so just curious to know if that could happen to someone over a period of time that their body gets used to it and it is no longer effective.

#2 funchas

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Posted 21 August 2011 - 11:42 AM

Hey all,

I am just curious to know if the medication you are put on can lose its effectiveness over time. My friend has been on Cymbalta for a couple of years now and has varied the dose as required. He now has a new drug that he will start tomorrow (not sure what it is) As his depression is so bad at present so just curious to know if that could happen to someone over a period of time that their body gets used to it and it is no longer effective.

Yes, it can happen. That's what people mean when they say their antidepressant's effects "fizzle out" after a while. SSRIs are notorious for that happening in some people. Supposedly the body gets used to the 'extra' serotonin (from it being around longer in the brain) and either stops making it on its own or just stops responding to it. End result is the same: the person stops responding to the medicine they had been on for awhile.

Usually changing the dosage or changing medications helps (with doctor's approval of course). If the person still doesn't respond to at least 2 other antidepressants, the depression is upgraded to treatment-resistant depression (so named due to its resistance to standard treatment protocols of antidepressants), and additional medications can be added to an antidepressant or other forms of treatment are considered. This form of depression is more challenging to treat, but most people will respond to some form of treatment eventually.


I wish the best for your friend! :) Hopefully he'll respond well to his new medication.

Edited by funchas, 21 August 2011 - 11:45 AM.


#3 Velthir

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Posted 21 August 2011 - 11:59 AM

SSRIs and SNRIs are fairly well known to poop out after a random period of time, although normally SNRIs aren't as prone to do so as SSRIs from what I've heard. Not so bad if you've not tried too many meds, can be a pain if you've gone through a lot of meds though. Not sure anyone is really sure why it happens though.

Dx: Bipolar II/III (antidepressant induced mixed states/hypomania)
Rx: 400mg lamotrigine (Lamictal), 800 mg/day of carbamazepine (Tegretol XR), 600 mg/day Zyban (bupropion/Wellbutrin SR)
Failed meds: Cymbalta, citalopram (Celexa), agomelatine (Valdoxan), lofepramine, mirtazapine (Remeron), sertraline (Zoloft), aripiprazole (Abilify), quetiapine (Seroquel), trimipramine (Surmontil)
Partial-success: nortriptyline/Pamelor, moclobemide (Aurorix/Manerix), reboxetine
 
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#4 Wilo77

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Posted 21 August 2011 - 11:24 PM

Thanks for the responses I am so lucky that my meds have been good with treating my PTSD

#5 Spiritual_Wanderer

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Posted 22 August 2011 - 11:22 AM

I have been on Lexapro for over 6 months and it seems to NOT be working as well and I'm wondering if I'm having that infamous "poop out" effect. I hate starting new meds and think I would rather ask to augment with another med than start a brand new one and have to taper off this.

It's unfortunate it happens, but I guess you gotta do what you gotta do. It seems like it's pretty common for psych meds to fizzle out and stop working over time.
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#6 Wilo77

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Posted 23 August 2011 - 12:05 AM

Just thought I'd update on my friend he is now switching to Pristiq from Cymbalta so fingers crossed things get sorted





#7 ja4445

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Posted 23 August 2011 - 03:36 AM

This has happend to me a few times workes gr8 and then quits on you! I took Remeron for about 6mths. I felt good maybe alittle to good for 4mths and then 1 morning it seemed like I was taking nothing @ all!

#8 starr

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Posted 23 August 2011 - 03:29 PM

Hi,

I have been on these meds for 20 years now and for me
they usually last around 5 years before they poop-out and
I have to switch to something else. Thankfully there
has always been something else out there that worked.
I am on a mood stabilizer and abilify along with my
anti-depressant so that may extend their effectiveness-
I dont know.

best wishes,
starr

#9 IsoZeiss

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Posted 23 August 2011 - 11:11 PM

Just thought I'd update on my friend he is now switching to Pristiq from Cymbalta so fingers crossed things get sorted





I used to be on Pristiq for a few months after my wellbutrin pooped out on me, and it worked really well. Pristiq was an awesome AD for me so I hope it works for your friend too.
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#10 KumaTaro

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Posted 14 September 2011 - 10:32 PM

I'm taking the plunge too. I've been on Cymbalta for about 8 years and am looking to switch to Pristiq. Although it has been good at keeping my depression at bay, I've been feeling "flat", experienced some loss of libido and gained weight. Hopefully this will be the change I need

#11 Sheepwoman

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Posted 15 September 2011 - 05:00 PM

I took Prozac and Lithium 14+ years. They both gave out at the same time. Have no clue why and I don't think the doc knew why. So, I've been on a new copmbo of meds 7 years and they're working fine. I hope they'll go over 14 years but one never knows.
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