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New Antidepressants On The Market!

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I've been researching this due to my treatment resistant condition lately. Here's some info I found, Mirapex is an off label drug for parkinsons which is supposed to work for depression by increasing dopamine. Reboxetine(norepinephrine), pristiq(cleaner effexor), Emsam, and Tramadol. Tramadol is one that really caught my attention as I've been on this for years for a back injury. I have noticed when I'm not in a lot of pain that it seems to help. I just wonder what Doctors think about prescribing this on a permanent basis when nothing else is working. I also wonder if it would wear out or cause stomach problems,etc. if taken on a regular basis??

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Posted

I've been researching this due to my treatment resistant condition lately. Here's some info I found, Mirapex is an off label drug for parkinsons which is supposed to work for depression by increasing dopamine. Reboxetine(norepinephrine), pristiq(cleaner effexor), Emsam, and Tramadol. Tramadol is one that really caught my attention as I've been on this for years for a back injury. I have noticed when I'm not in a lot of pain that it seems to help. I just wonder what Doctors think about prescribing this on a permanent basis when nothing else is working. I also wonder if it would wear out or cause stomach problems,etc. if taken on a regular basis??

I took Tramadol for about 1 1/2 years for severe cramps from IUD birth control. I don't know if it helped depression, as I was not severly depressed at the time. But it did give me a lot of stomach problems... in fact, it got to the point where I would get voilently sick about an hour after taking it. So my doc switched me to Darvacet, and about 6 months ago I had the IUD removed due to side effects.

Anyway... yes, Tramadol can cause stomach problems from long term use... at least for me.

Good luck finding something that will work for you, I know how difficult it can be.

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Tramadol does kind of make sense if you think about it. You aren't supposed to take tramadol with an SSRI, due to the possiblity or seretonin syndrome. So it does have some effect on seretonin, although I don't pretend to know how. Thank God science continues.

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Posted

Most of the meds used to treat Parkinsons do work on dopamine levels. I don't know if they're FDA approved for treatment of depression or other MI's. You'd have to look at what they're used to treat illnesses/conditions or ask your pdoc for feedback and advice.

Tramadol/Ultrem is an analgesic used primarily for pain relief similar to Vicodin, Darvocet, Percocet, etc. and may cause dependency or addiction (takes higher doses for effective pain relief.) It did nothing for my pain. It did increase my depression. I usually take these types of meds with a bit of food as I'm prone to bleeding ulcers.

Serotonin, dopamine and norepinephrine levels can effect depression. Have no clue regarding how or which one(s) pdocs determine to treat. Researchers are still trying to find out how the brain transmits and assimilates information.

Sheepwoman

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Posted

i came across an article in NWS&T magazine, seems norepinephrine actually plays a bigger role than once thought with dopamine and the action of opiates [naturally occurrng in the body and otherwise].

this article is about a test done with mice and can be found w/google.

i found it very interesting

i know synthetic opiates relieve my depression and make me enjoy things like socializing, reading, smiling...

but the cons are plentiful..... can't get a script, tough on your kidneys in the long run and its an expensive thing to upkeep.

i think its glaxo that's working on a triple-reuptake drug... something that works on dopamine, NE and seratonin.. still in trials, though.

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Posted

Tried the tramadol with success at first but it weened out quick(a week) and the depression/social anxiety came back along with stomach pain. $^%$&^$&^$!%@##^$! I am getting so tired of this!!! I sometimes wonder if life is even worth living anymore if you can't interact with people and have some form of relationship on top of feeling atleast OK. My parents tell me often that there are people a lot worse off than me (true) such as people in Darfur among many others and atleast I have a caring family and a roof over my head. She does have a point and it helps a little to think in this manner but sometimes I wish I could be worse off in one way to be happy and interact with people and have the motivation to live life and keep trying. Not to put meds down or anything but I think after trying 90% of the psych meds out there you start to feel empty, I feel like my brain just won't function anymore even with simple daily activities. :flowers::hearts:

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