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seven100

How Long Does It Take To Adjust To Bupropion?

53 posts in this topic

Posted

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My doctor prescribed Bupropion ten days ago, 150mg twice daily. This is the first antidepressant I've taken. I expected it to be a more or less benign experience. I figured the changes would be gradual. That isn't what happened. For the first two days I felt almost like I had taken acid or something. It was extreme. I'm a recovering alcoholic and addict, who hasn't had anything stronger than caffeine for the last four years, maybe that's why it packed such a wallop. I promise you I was almost non-functional. By the third day things had begun to mellow out a bit, enough so that I could work and do the things I need to do. Now it's the tenth day, and I still get that drugged feeling each time I take this medication, and frankly I don"t like it a whole lot. Has anyone had an experience like this. Will the medicated feeling pass? I hope so, because I really am feeling somewhat more positive lately. Is my dose too high?

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Posted

My doctor prescribed Bupropion ten days ago, 150mg twice daily. This is the first antidepressant I've taken. I expected it to be a more or less benign experience. I figured the changes would be gradual. That isn't what happened. For the first two days I felt almost like I had taken acid or something. It was extreme. I'm a recovering alcoholic and addict, who hasn't had anything stronger than caffeine for the last four years, maybe that's why it packed such a wallop. I promise you I was almost non-functional. By the third day things had begun to mellow out a bit, enough so that I could work and do the things I need to do. Now it's the tenth day, and I still get that drugged feeling each time I take this medication, and frankly I don"t like it a whole lot. Has anyone had an experience like this. Will the medicated feeling pass? I hope so, because I really am feeling somewhat more positive lately. Is my dose too high?

I am a recovering alcoholic also. I had the same experience you had. I took a 150 mg XL at work and wished I had waited for a day off. I was wigged out all day and half of the next day. I called my Psy. and told her I'm NOT taking the full dose of this . She changed my script to 100 mg and told me to work up to 3X a day(300)mgs. I still was not able to handle 100mg at a time,so I cut up the pill and took small pieces, a little bit bigger piece a day. (be carefull cutting the XL's it might release it all at once). I like the SL better. Wellbutrin was my first drug in sobriety also. I was kind of scared by the potency of 1 pill. I took it real slow. It took me about 6 weeks to get up to 100mg 3x day.

The good news is it works well and yes, the drugged feeling goes away. I am still taking it, about 2years now. I got really drowsy from it so I took it once a day at bedtime till I did not feel any side effects then worked a second and third dose in on weekends when I could take a nap.

Taking it with food cuts down the punch a lot. Don't wash them down with hot coffee it melts them too fast.

Hope I helped you

Later,

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Posted

I don't think your prior alcohol &/or drug experience has anything to do with the bad reaction. I haven't had a drink in a month (I drink occasionally) and on day 3 of Wellbutrin last week I felt like I was on a really bad drug trip & was having psychotic thoughts, too. My GP told me that some people are just unable to take Wb & if they experience bizarre episodes they should consider a different drug. I'm starting a new med next week.

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Posted

Thanks everyone for the information. Actually, as of today things have evened out quite a bit. It's a huge relief, because I really would like for this to work.

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Posted

Good luck. I hope it works out for you.

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Thanks everyone for the information. Actually, as of today things have evened out quite a bit. It's a huge relief, because I really would like for this to work.

Good to hear that! Let us know how it goes.

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Posted

I to had my doubts about taking Wellbutrin. I went through ups and downs and that "drugged" feeling. After 7 weeks I'll say that nearly all side effects are gone and it's beginning to work like it should.

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Posted

My doctor prescribed Bupropion ten days ago, 150mg twice daily. This is the first antidepressant I've taken. I expected it to be a more or less benign experience. I figured the changes would be gradual. That isn't what happened. For the first two days I felt almost like I had taken acid or something. It was extreme. I'm a recovering alcoholic and addict, who hasn't had anything stronger than caffeine for the last four years, maybe that's why it packed such a wallop. I promise you I was almost non-functional. By the third day things had begun to mellow out a bit, enough so that I could work and do the things I need to do. Now it's the tenth day, and I still get that drugged feeling each time I take this medication, and frankly I don"t like it a whole lot. Has anyone had an experience like this. Will the medicated feeling pass? I hope so, because I really am feeling somewhat more positive lately. Is my dose too high?

I felt pretty stoned on my first week of Bupropion, too. I'd say after about ten days, the stoned-feeling got less severe, and by day 15 it was pretty much gone. :hearts:

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This is just a follow-up to my original post, and more questions. I'm now beginning my 6th week on Wellbutrin, actually Budeprion. Almost all of the side effects I experienced in the beginning have ceased. I no longer have that strange drugged feeling that I did in the beginning. The only thing that remains is a buzzing sound in my ears, but it's tolerable.

Unfortuneately some of the pleasant side effects have ceased as well. I would say that I definitely feel better emotionally. My friends and family have noticed a huge improvement, but for the last week or so I find that I'm exhausted once again. That much needed spurt of energy that the med gave me in the beginning is just gone. I take 150mg twice a day. The first dose I take in the morning, and I feel fine until about eight hours later, then I crash. If I take the second dose at this time, then no problems I'm back in business again. If I wait, and try to leave twelve hours between doses, I crash for those last four hours. I'm so tired I can't keep my eyes open, and I get a constant dull headache.

One would think this isn't such a problem. Why not just take the second dose eight hours later, and that works to some extent. The problem is that now there's a long gap between doses overnight. It's nearly impossible to wake up in the morning, and usually it's the pounding headache that finally gets me up.

Does anyone have any suggestions for how to take this more successfully? Would it be better if I took the med three times a day? I could ask the doc for a lower mg tablet, and then take it every eight hours. Would a higher dosage help? Any suggestions would be appreciated.

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Posted

Hi seven100,

Are you taking the SR or the XL version of the med? If you are taking SR, you may want to ask your doc about switching to the XL since this releases more gradually than the SR. Then, if you take it every 12 hours it may smooth things out a bit for you. Hope this helps!

Guru

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Hey~ I'm new to the board but I've been lurking for 2-3 days. I wanted to ask the same question. I'm done with the so-called "Honeymoon Phase" which I loved and now that's over, I'm back to how I was before. I am sleeping all the time and eating a lot of junk food to fill that hole in my heart <3 Am I suppose to progress from that state or do I have to wait a few weeks. What happened to each of you after the first few energetic days passed?

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Hey~ I'm new to the board but I've been lurking for 2-3 days. I wanted to ask the same question. I'm done with the so-called "Honeymoon Phase" which I loved and now that's over, I'm back to how I was before. I am sleeping all the time and eating a lot of junk food to fill that hole in my heart <3 Am I suppose to progress from that state or do I have to wait a few weeks. What happened to each of you after the first few energetic days passed?

I felt pretty low after the honeymoon nearly 5 weeks ago, then went up slightly, then back down, then hovered somewhere in between low and average. Someone in this forum referred to it as a roller coaster, and that's absolutely what it felt like. For me, there was no noticeable improvement until about a week ago. Some improve sooner, others later, but the rule of thumb is 4-8 weeks. Hopefully you see it sooner :hearts:

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I've been on it for just a week now. The first couple of days my brain felt blinky, like it was having power surges or something. Since then I've had intermittent headaches and poor sleep, neither of which were an issue before I started taking it. I'm not noticing any changes, but the past couple of days I've felt worse, but I wonder if that's related to PMS because it is a familiar feeling, but I'm a bit more um, outspoken about my mood much to my husband's dismay. :hearts: :hearts:

I know it's only been a week and I need to give it a chance, but I'm really not liking it right now.

A few years back I had been on it and don't remember these side effects, though I was on the SR version. I did have night sweats and vivid dreams, but at least I was sleeping. :flowers:

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Posted

I've been on it for just a week now. The first couple of days my brain felt blinky, like it was having power surges or something. Since then I've had intermittent headaches and poor sleep, neither of which were an issue before I started taking it. I'm not noticing any changes, but the past couple of days I've felt worse, but I wonder if that's related to PMS because it is a familiar feeling, but I'm a bit more um, outspoken about my mood much to my husband's dismay. :hearts: :hearts:

I know it's only been a week and I need to give it a chance, but I'm really not liking it right now.

A few years back I had been on it and don't remember these side effects, though I was on the SR version. I did have night sweats and vivid dreams, but at least I was sleeping. :flowers:

An hour and a half after posting this (maybe 2.5 hours since taking the med) I feel like I am going to fly out of my skin. I'm going to call my dr office and talk with her nurse, I don't think I want to continue taking this. I have xanax for the anxiety for my trip... I'll take that and deal with it, but I just don't know if I want to be feeling this way and being so far from home. I don't know if I will be feeling like this in 3 weeks, but honestly, I don't want to wait around to find out! I don't know what to do.

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Posted

I've been on it for just a week now. The first couple of days my brain felt blinky, like it was having power surges or something. Since then I've had intermittent headaches and poor sleep, neither of which were an issue before I started taking it. I'm not noticing any changes, but the past couple of days I've felt worse, but I wonder if that's related to PMS because it is a familiar feeling, but I'm a bit more um, outspoken about my mood much to my husband's dismay. :hearts: :hearts:

I know it's only been a week and I need to give it a chance, but I'm really not liking it right now.

A few years back I had been on it and don't remember these side effects, though I was on the SR version. I did have night sweats and vivid dreams, but at least I was sleeping. :flowers:

Eieio,

I'm not a doctor so I can't tell you what is right for you, but I will say that Wellbutrin does have a 'difficult' startup phase...it certainly requires the most patience of any of the AD's and more often then not people give up before they can get any benefit to the medication. I'm sure you know about the 6-8 weeks of feeling benefits..but also during this time your adjusting to the medicine so things can get kind of crazy to be sure...I found it was worth the struggles and have noticed a huge AD benefit after settling in...unfortuantely the first few weeks were a tough road.

If you can my adice is to hang in there...but if its too much then don't force it as its not for everyone..

Good Luck and keep us posted

Darken

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Posted

Eieio,

I'm not a doctor so I can't tell you what is right for you, but I will say that Wellbutrin does have a 'difficult' startup phase...it certainly requires the most patience of any of the AD's and more often then not people give up before they can get any benefit to the medication. I'm sure you know about the 6-8 weeks of feeling benefits..but also during this time your adjusting to the medicine so things can get kind of crazy to be sure...I found it was worth the struggles and have noticed a huge AD benefit after settling in...unfortuantely the first few weeks were a tough road.

If you can my adice is to hang in there...but if its too much then don't force it as its not for everyone..

Good Luck and keep us posted

Darken

I bet you're right. But I am leaving in less than 3 weeks on a trip abroad with 30 or so other people. I am having enough anxiety about this trip because of my high need of being alone and not wanting to be around people 24/7. I'm afraid by continuing the meds at this time, still during the adjustment period that I'm going to have a total meltdown there. TBPH, the thought of feeling this way, so far away from the familiar and comfortable is scarier to me than going on the trip feeling somewhat depressed, if that makes any sense. So maybe this is the right med for me, but I do believe this is the wrong time to be starting it. I wish I had realised that before I took my first dose last week. :-(

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I bet you're right. But I am leaving in less than 3 weeks on a trip abroad with 30 or so other people. I am having enough anxiety about this trip because of my high need of being alone and not wanting to be around people 24/7. I'm afraid by continuing the meds at this time, still during the adjustment period that I'm going to have a total meltdown there. TBPH, the thought of feeling this way, so far away from the familiar and comfortable is scarier to me than going on the trip feeling somewhat depressed, if that makes any sense. So maybe this is the right med for me, but I do believe this is the wrong time to be starting it. I wish I had realised that before I took my first dose last week. :-(

I'm inclined to agree with you that this may not have been the right time to start up with the Wellbutrin. I'm also a little puzzled as to why your doc would suggest it when you were having so much anxiety about your trip. Wellbutrin can be known to increase anxiety so it doesn't seem like the best choice if you were already anxious.

Perhaps when you get back you can give it another shot...I'm sorry you had so many problems so early on, keep us posted on how your doing if you can.

Darken

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Posted

I'm inclined to agree with you that this may not have been the right time to start up with the Wellbutrin. I'm also a little puzzled as to why your doc would suggest it when you were having so much anxiety about your trip. Wellbutrin can be known to increase anxiety so it doesn't seem like the best choice if you were already anxious.

Perhaps when you get back you can give it another shot...I'm sorry you had so many problems so early on, keep us posted on how your doing if you can.

Darken

It was rx'd to me because I had such good luck with it the last time I was on it (over 2 yrs ago); after trying zoloft, paxil, celexa and effexor with no long term or positive improvement. I think the effexor I was on for just a few weeks and that was just scary to me, I felt so ragey and like a screaming mimi. It was awful. I don't know what else to try, or if I should even bother.

What is really frustrating to me today, is I called my Dr's office to talk to someone there about it yesterday morning and no one has called me back. I've got another appt scheduled in a couple of weeks, I'm going to be sure to let her know that no one called back. I will try again on Monday, jsut to make the effort. This is a new practice to me and I don't like how the office is managed at all. The doctors are lovely, but it's not managed well and that's unfortunate.

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My doctor prescribed Bupropion ten days ago, 150mg twice daily. This is the first antidepressant I've taken. I expected it to be a more or less benign experience. I figured the changes would be gradual. That isn't what happened. For the first two days I felt almost like I had taken acid or something. It was extreme. I'm a recovering alcoholic and addict, who hasn't had anything stronger than caffeine for the last four years, maybe that's why it packed such a wallop. I promise you I was almost non-functional. By the third day things had begun to mellow out a bit, enough so that I could work and do the things I need to do. Now it's the tenth day, and I still get that drugged feeling each time I take this medication, and frankly I don"t like it a whole lot. Has anyone had an experience like this. Will the medicated feeling pass? I hope so, because I really am feeling somewhat more positive lately. Is my dose too high?

hi i have been on bupropion for bout 3 yrs n i felt the same way it does pass, but to be safe maybe ask ur doctor if u need to start on a lower dose. i started low n im now takin 300mg. This is the only medication that works for me so i would just give it a month n if u still feel drugged i would ask ur doctor.

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I've been on Budeprion XL 150 mg for 2 months, and 300 mg for 1 month. I haven't been feeling any consistent effects, so is it time to jump ship?

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Good Question...one way to know if Wellbutrin may work in the longterm is to ask yourself did you feel any effects whe starting up? Many people who have success with the medicine enjoy a brief period at the very beginning where they feel almost euphoric. As absurd as it sounds this can be a hint that you wil see improvement in the later stages of taking the med. After three months I would think you should start to see some improvement with your depression...but different meds affect people in different ways.

Have you had any side effects? This can be another sign the medicine is donig something..with me as my depression decreased my side effects remained constant...most of them eventually went away...but it was frustrating to experience so many of them during the course of startup.

In the end you are the best person to determine if you are going to benefit from this particular med...discuss it with your doctor, and think about if you have had ANY improvement...if not it may be time to move on to somethng else.

Darken

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My Opinion....I would probably stick with it a while longer. The 150mg is basically a starter dose. I was on that for a month, then went to the 300mg XL. I would say it took a good 4-5 months at the 300mg dose to have its full effect, in my case. Greg

I've been on Budeprion XL 150 mg for 2 months, and 300 mg for 1 month. I haven't been feeling any consistent effects, so is it time to jump ship?

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I am so spaced out it took me a while to figure out how to write a reply! That's not like me at all!

I started taking Wellbutrin 5 days ago and today I started having some sever side effects, so a googled it and found this forum! It has been so helpful...I feel like I am not alone!

So, today I had chest pains and I took a NitroQuick...I have mild angina. It knocked me for a loop. I was lying down and I thougt a few minutes had passed but it was over an hour before I managed to get up. The Nitro has never done that before. My chest pain did impove though. Not the dizziness or my general confusion...

I have been very restless and unable to focus to the extreem since I have taken Wellbutrin. Last night I was up until 3AM (I usually fall asleep by 11) and then I was unable to sleep. I took a 3 mg Melatonin and fell into a very restless sleep. This am I woke up to a phone call at 9am and could hardly put words together.

I have had sever Migraine headache the past few months, worse then any in the past. These were accompanied by thoughts of suicide. My neurologist became concerned and call a psychiatrist I have seen in the past and after 2 sessions he decided to try me on 75MG in the morning of Wellbutrin. AFter some blood tests he discovered that I am vitamin B6 deficient (we are waiting for other tests to come back) He said B6 deficiency may make one depressed. Insteed of waiting for a suppliment to kick in I wanted more instant relief.

But now I feel terrible...the doctor said it can take a while to work. I do not drink, smoke or do drugs, so this kind of tampering with my brain is not something I am not used to. I have tried various meds for headache/depression before all with negative results, Cymbalta and Effexor.

My question is this. Have any of you had a hard time "getting used to" Wellbutrin?

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:hearts: I also exercise every other day...but today I am so spacy I just can't do it. Much to myown regret I am not going to drive through the snow and ice to the health club. That make me feel awful.

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Hi Motownmom

Welcome to DF. Starting a new anti-depressant can be so rough. I recently started Celexa and have been feeling worse rather than better. I have taken Wellbutrin in the past and it is the only AD I didn't have any side effects with. I guess everyone is so different. I had horrible side effects with other meds though. Make sure you keep your doctor updated about how you're feeling. It does usually get better after a few weeks. Sorry I can't be of more help except to say that you're definitely not alone in this. I hope you feel better soon.

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