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Switchng From Cymbalta To Pristiq


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31 replies to this topic

#1 tina

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Posted 20 June 2008 - 09:07 PM

I have gained TONS of weight on Cymbalta and went to the Doctor today and he gave me samples of Pristiq. Who all has tried this? I will be taking it with Lamitical because of Bipolar? Any advice will be appreciated! I had been cutting back on my cymbalta for the past 2 weeks.

#2 Jkm

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Posted 25 June 2008 - 07:01 AM

Seeing that no one has replied to this, I wanted to say that this is the newest ad out there and hope you let us know how it goes for you!!!!

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#3 justanothermember

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Posted 03 July 2008 - 06:49 AM

I have gained TONS of weight on Cymbalta and went to the Doctor today and he gave me samples of Pristiq. Who all has tried this? I will be taking it with Lamitical because of Bipolar? Any advice will be appreciated! I had been cutting back on my cymbalta for the past 2 weeks.

Hi Tina.

This is great! I have been on Lamictal for years and Cymbalta for 4 months. The Cymbalta has caused weight gain of about 15 pounds in a month or so. Never before have I gained weight with any medication, and whats more is I cannot even get the weight off!

My doctor switched me to Pristiq just yesterday. I forget to ask him how to switch, so this morning I simply replaced a 60-mg tablet of Cymbalta with a 50-mg of Pristiq. Hope I'm still alive in a few hours!

The research I read on Pristiq is not very encouraging. Basically, it is a patent extender for Wyeth. The only difference in Pristiq and Effexor seems to be that the 50-mg dose is the actual therapeutic dose. There is no need for titration, so you will find out faster whether it works or not.

Cymbalta worked better than Effexor for my mood and anxiety but weight gain is something that will end up making me more depressed - something I will not live with. It should be interesting to see if the weight comes off. If it does, maybe the joy I get from losing weight will make up for the lack of efficacy from Pristiq.

Keep posting on this one!

#4 rambler

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Posted 07 July 2008 - 01:43 PM

I recently (2 weeks ago) was switched from Cymbalta to Pristiq. At the same time I was added Wellbutrin (the generic) at 300mg per day. My depression & nerves have been the worst in a long time. But I've heard this can happen with new WB users, so I honestly can't comment on the Pristiq.

#5 justanothermember

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Posted 08 July 2008 - 09:21 AM

Update: Day 6 on Pristiq.

Wow. This seems to be working great. I have more energy and motivation, decreased appetite, and am no longer taking naps during the day. What a difference from what appeared to be a slowed metabolism from the Cymbalta. As far as my mood, it is about the same as on Cymbalta but if my weight is controlled and my energy stays up, that alone will lift my mood.

Loving it so far.

#6 Cymbalta_Survivor

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Posted 20 July 2008 - 07:16 PM

Pristiq is basically a new form of Cymbalta, so be careful!! If you had negative side effects on Cymbalta, you will probably have them on Pristiq as well. The Wellbutrin may mask the negative Pristiq side effects at first, so monitor your feelings and energy level carefully. If you begin to feel tired, lethargic, and/or apathetic, I encourage you to re-evaluate your use of Pristiq. The Pristiq could be making you worse (like Cymbalta does to many people). Pristiq has only been on the market since Feb. 2008, so there is not much public info available yet.

You may only need the Wellbutrin to help you feel better.

#7 maintainin

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Posted 20 July 2008 - 09:32 PM

Pristiq is no way, shape or form related to cymbalta. It is the active metabolite of effexor.

If at first you don't succeed, then skydiving definitely isn't for you!

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#8 Cymbalta_Survivor

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Posted 22 July 2008 - 07:04 PM

Effexor, Cymbalta and Pristiq are all in the same category of anti-depressants: serotonin-norepinephrine reuptake inhibitor (SNRI).

#9 BrokenGrl

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Posted 22 July 2008 - 07:37 PM

I have gained TONS of weight on Cymbalta and went to the Doctor today and he gave me samples of Pristiq. Who all has tried this? I will be taking it with Lamitical because of Bipolar? Any advice will be appreciated! I had been cutting back on my cymbalta for the past 2 weeks.





I am on day 4 of taking Pristiq. I sure hope I dont gain weight. As for my depression, well there is no change but I guess it's too soon to tell. Everything I read on here about medication scares the heck out of me.

#10 4mykids

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Posted 10 July 2009 - 06:11 AM

I have gained TONS of weight on Cymbalta and went to the Doctor today and he gave me samples of Pristiq. Who all has tried this? I will be taking it with Lamitical because of Bipolar? Any advice will be appreciated! I had been cutting back on my cymbalta for the past 2 weeks.


I am looking into making this switch as well. I have gained weight on Cymbalta which is leaving me feel depressed. Have you noticed a loss of the weight you gained while on Cymbalta after the switch?

Edited by 4mykids, 10 July 2009 - 06:12 AM.


#11 Tinkerbell_kal

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Posted 10 July 2009 - 09:00 AM

I have gained TONS of weight on Cymbalta and went to the Doctor today and he gave me samples of Pristiq. Who all has tried this? I will be taking it with Lamitical because of Bipolar? Any advice will be appreciated! I had been cutting back on my cymbalta for the past 2 weeks.


I am looking into making this switch as well. I have gained weight on Cymbalta which is leaving me feel depressed. Have you noticed a loss of the weight you gained while on Cymbalta after the switch?



Hi 4MK,

I know what you mean about the weight gain on AD. Years back when I was on Paxil I gained about 40 pounds and was horribly depressed. Eventually I decided to stop taking them because of that. I am now on Cymbalta and have been for about 5 weeks now. I am just now getting my appetite back
(I had none when I first started Cymbalta) and if anything I've lost weight. I'm still scared to death that it may still happen on Cymbalta. How long have you been on it? It's crazy how some people gain, others lose. You just never know. I'm just trying to eat smart these days and hoping for the best.

Thanks!

TTysoon :hearts:

Tink
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"Pain of mind is worse than pain of body"

#12 4mykids

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Posted 10 July 2009 - 09:40 AM

Hi Tink,

I've been on Cymbalta for about 3 months now. It's just been in the last month that I've gained the weight and that's what has me terrified. 10 lbs in one month! I'm hoping the Pristiq will level out this weight thing. Other than the weight, I'm happy with the way it was working. I feel good, a little tired, but good.
You are right when you say it affects people differently. Just hang in there.

#13 Tinkerbell_kal

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Posted 10 July 2009 - 10:26 AM

Hi Tink,

I've been on Cymbalta for about 3 months now. It's just been in the last month that I've gained the weight and that's what has me terrified. 10 lbs in one month! I'm hoping the Pristiq will level out this weight thing. Other than the weight, I'm happy with the way it was working. I feel good, a little tired, but good.
You are right when you say it affects people differently. Just hang in there.



Hi again!

What dose are you on? I'm on the 60mg but I think I need an increase. I don't feel much of anything these days. I'm just at an even keel. Not as bad as I was, but not nearly where I want to be. I'm on it for Anxiety, OCD and severe Depression. I'm going to the doctor's next week and hopefully she will be able to help me and adjust the dose. I have a high tolerance to drugs so who knows. I had my Paxil dose increased many times as well.... so who knows. I just want to feel better, and I'm slowly losing hope :hearts:

Thanks again!
"When I get sad, I stop being sad, and be AWESOME instead!!

"Pain of mind is worse than pain of body"

#14 chel

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Posted 10 July 2009 - 11:36 AM

well after reading your posts i truely dont want to go on cymbalta!! i cant deal with anymore weight gain ! feeling fat and unwanted does nothing for my depression !!! ugh !

#15 4mykids

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Posted 11 July 2009 - 01:36 PM

Hi again!

What dose are you on? I'm on the 60mg but I think I need an increase. I don't feel much of anything these days. I'm just at an even keel. Not as bad as I was, but not nearly where I want to be. I'm on it for Anxiety, OCD and severe Depression. I'm going to the doctor's next week and hopefully she will be able to help me and adjust the dose. I have a high tolerance to drugs so who knows. I had my Paxil dose increased many times as well.... so who knows. I just want to feel better, and I'm slowly losing hope :hearts:

Thanks again!
[/quote]

Hi Tink,
I'm on 60 mg as well. I went back to my doctor after two months to have it increased and apparently the research shows that a higher dose isn't more effective. We waited it out and I am definitely feeling better. I was on 200mg of Zoloft a few years ago. Other than the weight issue, I am feeling much more relaxed, patient and balanced. I wish I could feel this way without taking medicine. The weight thing leaves me feeling too depressed though to continue with this medication, which essentially is counter productive. My pants were tight this morning when I went to put them on and I just started crying. I threw out all my "fat clothes" when I lost the weight because I didn't want going back to that to be an option for me. Don't lose hope though, Tink. Somewhere we'll find the answer we are looking for.

4MK

#16 cece_doe

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Posted 29 July 2009 - 12:12 AM

I'm sorry, I'm new here, but I'm a little baffled by all these people saying they gained all this weight. Every forum I've been to seems to have horror stories about gaining weight, yet no stories about people who HAVEN'T gained weight.

Well. I'm on Cymbalta and I actually lost weight. Crazy huh? When I was depressed I couldn't eat. It only makes sense that now that I'm happy, I would gain happy weight. Fortunately for me though, I was never the type to eat emotionally, whether happy or sad, so I didn't gain any weight. Seriously, weight gain is NOT a direct side effect - the increased appetite is.

Just exercise, and stop this whole I'mgoingtogetfat so Imightaswellgetfat mentality and go outside! Take a walk! Walk your dogs! Life is awesome.

Obviously, Cymbalta is working for me.

Let's here it for the people who are actually doing GREAT on ADs!! Speak up! Life is a helluva lot better than when I was depressed, fat or not!

#17 4mykids

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Posted 30 July 2009 - 05:40 AM

I'm switching back to Cymbalta. Pristiq is not working for me. In fact, I feel awful. I am impatient, irritable and the mood swings have my husband unsure whether he should hold me or run. Cymbalta was working for me mood-wise, better than any drug has ever. It was the weight gain and sexual side effects that bothered me most, but if I am smart with my eating and diligent about exercise, maybe I can combat that, at least the weight. Maybe I'll ask for some Viagra for women! Seriously though, Pristiq is not for me: headaches like I've never experienced, I haven't slept properly since I started taking it and when I am sleeping, I'm having really strange and disturbing dreams.

I got pretty sick making the switch to Pristiq-I hope it isn't as bad when I switch back.

#18 Krash4882

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Posted 15 August 2009 - 01:22 PM

Hello All -

I just joined today and this is my first post. I was diagnosed with low levels of seratonin back in 2006. I tried Prozac for 6 months, felt much better, went off it for 3 months, and started to get down again. My doctor switched me to Lexapro. I tried it for 1 year, and as I continued feeling pretty good, I tried going off it. Within another few months I started noticing symptoms again. I've always had trouble sleeping, problems with headaches/migraines, and just didn't feel motivated to do much of anything. My doctor said that 50% of people can go on an SSRI and come off in 6 months and be fine - the same thing goes for the 12 month "2nd trial." Since it was clear that I was worse off without the help of the medication, I began taking Cymbalta in the summer of 2007 and have recently been on 120mg a day. Over the last year I've noticed quite a bit of belly fat accumulating and became concerned about weight gain. I revamped my diet and began eating more small meals a day, lots of chicken/fish/fresh fruits/veggies, and maintained an exercise regimen. I even purchased and started the P90x workout program but had to stop around day 50 because I found out I have two herniated discs in my back (unrelated, unknown cause). I generally drink 1 gallon of water a day and focus on fresh/organic foods and low sugar snacks/meal replacements. I drink a lot of smoothies and add Acai, L-glutamine, and creatine supplments as well as take Tonalin-CLA to boost my metabolism's fat burning.

NONE of all the things I tried made a difference. I was shocked that I couldn't get rid of ANY excess body fat while going through the rigorous P90X workout program. Since I've been hurt, I haven't been able to exercise much, but I have maintained eating healthy and drinking plenty of water (avoiding pop and other sugar filled drinks). I didn't gain much more weight, but it feels/looks like I've lost some muscle weight and continue gaining fat weight in my abdominal area. This frustration has KILLED my self esteem and has made me feel more depressed than usual. I talked to my doctor about my weight/body fat % concerns and he told me I look fine and not to worry about it. I couldn't accept that and started researching to see if Cymbalta may be part of the problem. Over the last year or so I've felt in kind of an indifferent "fog" - not so many highs and lows, just an every day average feeling. I've noticed that since I've been on Cymbalta I have battled sugar cravings at various times of the day, and found myself snacking all the time, even into the night. I'm doing all I can now to keep snack foods out of my house and not eating anything before bed.

After looking into Cymbalta, from what I could find, several other people seem to attribute weight gain (specifically fat) to being on Cymbalta. After seeing so many commercials about adding Abilify to help with symptoms, and now seeing Pristiq commercials, I started looking into switching to Pristiq. I have read a lot of people's testimonies who have made the switch and they have noticed a better overall feeling and even dropped weight in a lot of cases. I called my doctor and requested to switch over from Cymbalta to Pristiq. I know going off of Cymbalta has a withdrawl period, but my doctor explained that switching right to Pristiq would not be a problem and I shouldn't experience any problems. Maybe it's just a psychological thing and/or something new we're all looking for hope in, but I'm going to give Pristiq a try and see how my body and mind respond to it. Lately I've remained in a depressed fog, and being stuck at home because I can't do much of any physical activity has not helped. I just want to enjoy more things in life instead of constantly thinking about the things I'm unhappy about. I should look forward to walking my dog, taking care of my house, taking good care of myself, and so many other things. Here's to hoping that Pristiq gives me some assistance in accomplishing my goal. I don't think that Pristiq is going to be some kind of miracle weight loss drug - but maybe by getting rid of the Cymbalta, Pristiq will have positive effects on my seratonin levels and my body will not otherwise have the issues I've been dealing with (low metabolism, belly fat gain). Before being treated for depression/anxiety (I'm also taking Xanax as needed), I was stick thin no matter what I ate (obviously changes with age, but I'm only 26). I don't know what's changed, but I want to get back to being happy about myself and my life.


I was working out 4-5 days a week when I first started noticing my belly sticking out further and further. In August of 2008 I had to have my gall bladder removed. I'm sure this has played a factor in my digestive system. I have to take a pill once or twice a day to absorb some of the bile that just sits in my intestine now that bile just flows directly into my intestines instead of being stored in the gall bladder and pumped out when needed. I believe not having the gall bladder can have some effects on the body's ability to emulsify fats - but my doctors have said that if anything, more fats should just be excreted as waste, not digested and stored. On top of the depression issues, I'm also trying to figure out the effects of not having a gall bladder can be.

Thanks to anyone who reads/replies. Any advice is appreciated. I will be starting Pristiq today - I will post updates as things move along.

Matt

Edited by Krash4882, 15 August 2009 - 01:34 PM.


#19 Bestwishes

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Posted 15 August 2009 - 01:38 PM

Hello,

I am new here also and found this site by searching about Pristiq. I was on 20 mg of lexapro and it never seemed to work that well. After some serious life events my depression got worse so my doctor put me on Pristiq. I am on day 3 and so far am feeling better. At least I want to get out of bed now! I feel a little flat lined but that's ok for me right now.
My depression is much better it seems. Hope this will work. I have cut back my lexapro to 10 mg for 2 weeks then I am supposed to stop it. That scares me a little!

#20 Zoki

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Posted 02 September 2009 - 10:42 AM

Pristiq is basically a new form of Cymbalta, so be careful!! If you had negative side effects on Cymbalta, you will probably have them on Pristiq as well. The Wellbutrin may mask the negative Pristiq side effects at first, so monitor your feelings and energy level carefully. If you begin to feel tired, lethargic, and/or apathetic, I encourage you to re-evaluate your use of Pristiq. The Pristiq could be making you worse (like Cymbalta does to many people). Pristiq has only been on the market since Feb. 2008, so there is not much public info available yet.

You may only need the Wellbutrin to help you feel better.



Not true for everybody, I'm new to AD's and started taking Cymbalta about 4 months ago, I started feeling good at first, but then had problems sleeping and getting sleepy with low energy all day. I discussed my issues with my Doc, and he suggested I change to Pristiq and WOW!...what a difference. I've never felt so good before, high energy, focused, no sleepiness, no insomnia...just great.

It's been two weeks on the regular 50mg dose and I have not experienced any notable side effects.

Hope this helps anybody debating the switch.

#21 dhermangub

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Posted 02 September 2009 - 04:09 PM

[quote name='BettyNaeini' date='Aug 15 2009, 02:38 PM' post='553678']
Hello,

I am new here also and found this site by searching about Pristiq. I was on 20 mg of lexapro and it never seemed to work that well. After some serious life events my depression got worse so my doctor put me on Pristiq. I am on day 3 and so far am feeling better. At least I want to get out of bed now! I feel a little flat lined but that's ok for me right now.
My depression is much better it seems. Hope this will work. I have cut back my lexapro to 10 mg for 2 weeks then I am supposed to stop it. That scares me a little!
My name is Dave and I started Pristiq 9 days ago. I am still feeling nausea and dizzy..but i will give it a lot more time for it to take affect. I hope it works. I am at my wits end.

#22 gardenhoe

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Posted 11 November 2009 - 11:58 PM

Pristiq is basically a new form of Cymbalta, so be careful!! If you had negative side effects on Cymbalta, you will probably have them on Pristiq as well. The Wellbutrin may mask the negative Pristiq side effects at first, so monitor your feelings and energy level carefully. If you begin to feel tired, lethargic, and/or apathetic, I encourage you to re-evaluate your use of Pristiq. The Pristiq could be making you worse (like Cymbalta does to many people). Pristiq has only been on the market since Feb. 2008, so there is not much public info available yet.

You may only need the Wellbutrin to help you feel better.



Not true for everybody, I'm new to AD's and started taking Cymbalta about 4 months ago, I started feeling good at first, but then had problems sleeping and getting sleepy with low energy all day. I discussed my issues with my Doc, and he suggested I change to Pristiq and WOW!...what a difference. I've never felt so good before, high energy, focused, no sleepiness, no insomnia...just great.

It's been two weeks on the regular 50mg dose and I have not experienced any notable side effects.

Hope this helps anybody debating the switch.


How did you do the switch from Cymbalta to Pristiq? I have been on Cymbalta for 3 months and my doc and pharmacist disagree on how I should do it . . . any guidance would be appreciated. Also, did you get really sick when you started the Cymbalta?

#23 christinalove999

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Posted 13 December 2009 - 02:29 PM

I have gained TONS of weight on Cymbalta and went to the Doctor today and he gave me samples of Pristiq. Who all has tried this? I will be taking it with Lamitical because of Bipolar? Any advice will be appreciated! I had been cutting back on my cymbalta for the past 2 weeks.


that is so weird, i heard cymbalta makes you lose weight, i also have gained. i just got switched today from cymbalta to pristq. Does pristq make yu gain weight??

#24 christinalove999

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Posted 13 December 2009 - 02:33 PM


Hello, I just joined today, I found this sight when i googled pristq. So how has it been working for you?? :snowman1:
I just joined today and this is my first post. I was diagnosed with low levels of seratonin back in 2006. I tried Prozac for 6 months, felt much better, went off it for 3 months, and started to get down again. My doctor switched me to Lexapro. I tried it for 1 year, and as I continued feeling pretty good, I tried going off it. Within another few months I started noticing symptoms again. I've always had trouble sleeping, problems with headaches/migraines, and just didn't feel motivated to do much of anything. My doctor said that 50% of people can go on an SSRI and come off in 6 months and be fine - the same thing goes for the 12 month "2nd trial." Since it was clear that I was worse off without the help of the medication, I began taking Cymbalta in the summer of 2007 and have recently been on 120mg a day. Over the last year I've noticed quite a bit of belly fat accumulating and became concerned about weight gain. I revamped my diet and began eating more small meals a day, lots of chicken/fish/fresh fruits/veggies, and maintained an exercise regimen. I even purchased and started the P90x workout program but had to stop around day 50 because I found out I have two herniated discs in my back (unrelated, unknown cause). I generally drink 1 gallon of water a day and focus on fresh/organic foods and low sugar snacks/meal replacements. I drink a lot of smoothies and add Acai, L-glutamine, and creatine supplments as well as take Tonalin-CLA to boost my metabolism's fat burning.

NONE of all the things I tried made a difference. I was shocked that I couldn't get rid of ANY excess body fat while going through the rigorous P90X workout program. Since I've been hurt, I haven't been able to exercise much, but I have maintained eating healthy and drinking plenty of water (avoiding pop and other sugar filled drinks). I didn't gain much more weight, but it feels/looks like I've lost some muscle weight and continue gaining fat weight in my abdominal area. This frustration has KILLED my self esteem and has made me feel more depressed than usual. I talked to my doctor about my weight/body fat % concerns and he told me I look fine and not to worry about it. I couldn't accept that and started researching to see if Cymbalta may be part of the problem. Over the last year or so I've felt in kind of an indifferent "fog" - not so many highs and lows, just an every day average feeling. I've noticed that since I've been on Cymbalta I have battled sugar cravings at various times of the day, and found myself snacking all the time, even into the night. I'm doing all I can now to keep snack foods out of my house and not eating anything before bed.

After looking into Cymbalta, from what I could find, several other people seem to attribute weight gain (specifically fat) to being on Cymbalta. After seeing so many commercials about adding Abilify to help with symptoms, and now seeing Pristiq commercials, I started looking into switching to Pristiq. I have read a lot of people's testimonies who have made the switch and they have noticed a better overall feeling and even dropped weight in a lot of cases. I called my doctor and requested to switch over from Cymbalta to Pristiq. I know going off of Cymbalta has a withdrawl period, but my doctor explained that switching right to Pristiq would not be a problem and I shouldn't experience any problems. Maybe it's just a psychological thing and/or something new we're all looking for hope in, but I'm going to give Pristiq a try and see how my body and mind respond to it. Lately I've remained in a depressed fog, and being stuck at home because I can't do much of any physical activity has not helped. I just want to enjoy more things in life instead of constantly thinking about the things I'm unhappy about. I should look forward to walking my dog, taking care of my house, taking good care of myself, and so many other things. Here's to hoping that Pristiq gives me some assistance in accomplishing my goal. I don't think that Pristiq is going to be some kind of miracle weight loss drug - but maybe by getting rid of the Cymbalta, Pristiq will have positive effects on my seratonin levels and my body will not otherwise have the issues I've been dealing with (low metabolism, belly fat gain). Before being treated for depression/anxiety (I'm also taking Xanax as needed), I was stick thin no matter what I ate (obviously changes with age, but I'm only 26). I don't know what's changed, but I want to get back to being happy about myself and my life.


I was working out 4-5 days a week when I first started noticing my belly sticking out further and further. In August of 2008 I had to have my gall bladder removed. I'm sure this has played a factor in my digestive system. I have to take a pill once or twice a day to absorb some of the bile that just sits in my intestine now that bile just flows directly into my intestines instead of being stored in the gall bladder and pumped out when needed. I believe not having the gall bladder can have some effects on the body's ability to emulsify fats - but my doctors have said that if anything, more fats should just be excreted as waste, not digested and stored. On top of the depression issues, I'm also trying to figure out the effects of not having a gall bladder can be.

Thanks to anyone who reads/replies. Any advice is appreciated. I will be starting Pristiq today - I will post updates as things move along.

Matt
[/quote]


#25 marylander

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Posted 18 December 2009 - 05:08 PM

Hi Matt--

How did the switch from Cymbalta to Pristiq go, now that a few more months have passed? Have any others had weight loss after switching?

I have been on Cymbalta for 4 years now and have gained 50 lbs.! First my psychiatrist made it seem like my fault, then my doctor: I was trying to "protect myself" from having contact from others, it was because I wasn't eating well or exercising enough, it was because my metabolism is different because I've entered my 30s, etc. I couldn't understand it because I've always been a healthy eater and had a slim body and small frame before starting Cymbalta. And dieting and doing strenuous workouts have done little to reverse the weight gain. I can't bear to look at photos of myself anymore! For years Cymbalta denied the weight gain side effect, only now it seems doctors have changed their tune. Was glad to read that others had a similar experience of weight gain-- now I know it's not my fault.

I would like to try Pristiq, if others have had luck with weight loss while on it. Cymbalta was working well for 2-3 years, but now it seems like my old irritability and bad temper is returning, and I'm constantly tired in the afternoon and am prone to napping. Could be time to try a new prescription.

--M





Hello, I just joined today, I found this sight when i googled pristq. So how has it been working for you?? :snowman1:
I just joined today and this is my first post. I was diagnosed with low levels of seratonin back in 2006. I tried Prozac for 6 months, felt much better, went off it for 3 months, and started to get down again. My doctor switched me to Lexapro. I tried it for 1 year, and as I continued feeling pretty good, I tried going off it. Within another few months I started noticing symptoms again. I've always had trouble sleeping, problems with headaches/migraines, and just didn't feel motivated to do much of anything. My doctor said that 50% of people can go on an SSRI and come off in 6 months and be fine - the same thing goes for the 12 month "2nd trial." Since it was clear that I was worse off without the help of the medication, I began taking Cymbalta in the summer of 2007 and have recently been on 120mg a day. Over the last year I've noticed quite a bit of belly fat accumulating and became concerned about weight gain. I revamped my diet and began eating more small meals a day, lots of chicken/fish/fresh fruits/veggies, and maintained an exercise regimen. I even purchased and started the P90x workout program but had to stop around day 50 because I found out I have two herniated discs in my back (unrelated, unknown cause). I generally drink 1 gallon of water a day and focus on fresh/organic foods and low sugar snacks/meal replacements. I drink a lot of smoothies and add Acai, L-glutamine, and creatine supplments as well as take Tonalin-CLA to boost my metabolism's fat burning.

NONE of all the things I tried made a difference. I was shocked that I couldn't get rid of ANY excess body fat while going through the rigorous P90X workout program. Since I've been hurt, I haven't been able to exercise much, but I have maintained eating healthy and drinking plenty of water (avoiding pop and other sugar filled drinks). I didn't gain much more weight, but it feels/looks like I've lost some muscle weight and continue gaining fat weight in my abdominal area. This frustration has KILLED my self esteem and has made me feel more depressed than usual. I talked to my doctor about my weight/body fat % concerns and he told me I look fine and not to worry about it. I couldn't accept that and started researching to see if Cymbalta may be part of the problem. Over the last year or so I've felt in kind of an indifferent "fog" - not so many highs and lows, just an every day average feeling. I've noticed that since I've been on Cymbalta I have battled sugar cravings at various times of the day, and found myself snacking all the time, even into the night. I'm doing all I can now to keep snack foods out of my house and not eating anything before bed.

After looking into Cymbalta, from what I could find, several other people seem to attribute weight gain (specifically fat) to being on Cymbalta. After seeing so many commercials about adding Abilify to help with symptoms, and now seeing Pristiq commercials, I started looking into switching to Pristiq. I have read a lot of people's testimonies who have made the switch and they have noticed a better overall feeling and even dropped weight in a lot of cases. I called my doctor and requested to switch over from Cymbalta to Pristiq. I know going off of Cymbalta has a withdrawl period, but my doctor explained that switching right to Pristiq would not be a problem and I shouldn't experience any problems. Maybe it's just a psychological thing and/or something new we're all looking for hope in, but I'm going to give Pristiq a try and see how my body and mind respond to it. Lately I've remained in a depressed fog, and being stuck at home because I can't do much of any physical activity has not helped. I just want to enjoy more things in life instead of constantly thinking about the things I'm unhappy about. I should look forward to walking my dog, taking care of my house, taking good care of myself, and so many other things. Here's to hoping that Pristiq gives me some assistance in accomplishing my goal. I don't think that Pristiq is going to be some kind of miracle weight loss drug - but maybe by getting rid of the Cymbalta, Pristiq will have positive effects on my seratonin levels and my body will not otherwise have the issues I've been dealing with (low metabolism, belly fat gain). Before being treated for depression/anxiety (I'm also taking Xanax as needed), I was stick thin no matter what I ate (obviously changes with age, but I'm only 26). I don't know what's changed, but I want to get back to being happy about myself and my life.


I was working out 4-5 days a week when I first started noticing my belly sticking out further and further. In August of 2008 I had to have my gall bladder removed. I'm sure this has played a factor in my digestive system. I have to take a pill once or twice a day to absorb some of the bile that just sits in my intestine now that bile just flows directly into my intestines instead of being stored in the gall bladder and pumped out when needed. I believe not having the gall bladder can have some effects on the body's ability to emulsify fats - but my doctors have said that if anything, more fats should just be excreted as waste, not digested and stored. On top of the depression issues, I'm also trying to figure out the effects of not having a gall bladder can be.

Thanks to anyone who reads/replies. Any advice is appreciated. I will be starting Pristiq today - I will post updates as things move along.

Matt



#26 hope2bhappier

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Posted 04 January 2010 - 11:48 PM

I have been taking Pristiq for about 9 months and love it except for some side effects. It makes me grind my teeth all the time so bad and I now have cholesterol issues. I will actually be switching from Pristiq to Cymbalta next week. That is too bad about the weight gain. I am really worried about that. I heard that it decreases appetite though. Pristiq doesn't really affect your appetite at all. For me anyway. I didn't gain or lose weight. It took awhile for it to work (about 6 weeks to feel normal) but it really helped my anxiety alot. I wouldn't say that I was on top of the world happy but it definitly took the edge off of life.

#27 cingqueen

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Posted 06 January 2010 - 02:03 PM

I have gained TONS of weight on Cymbalta and went to the Doctor today and he gave me samples of Pristiq. Who all has tried this? I will be taking it with Lamitical because of Bipolar? Any advice will be appreciated! I had been cutting back on my cymbalta for the past 2 weeks.



Tina,
i was on Cymbalta for over 5 years...over the last year it has decreased in working for me so my dr decreased me from 60 mg to 30 mg and then changed me to 50 mg of Pristiq...this is day 4 on Pristiq and i am still having withdrawal side effects from the Cymbalta...last night, i thought i was going nuts...the "brain zaps" and the "eye twitches" have drove me insane...can you share any withdraw symptoms that you may of had?
Thanks...
Cingqueen

#28 annamac

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Posted 14 January 2010 - 09:06 PM

I was given Pristiq after taking Effexor XR 150mg for about 12 years. The Effexor had begun to cause headaches. Pristiq did nothing for me at all. I gave it a good try, about 6 months or so and nothing. Just blah. I will tell you that the switch from Effexor to Pristiq was seamless, no side effects. I am now taking Cymbalta and I am plumper than ever, thank you Cymbalta!

Edited by annamac, 14 January 2010 - 09:09 PM.


#29 cingqueen

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Posted 14 January 2010 - 09:23 PM

I was given Pristiq after taking Effexor XR 150mg for about 12 years. The Effexor had begun to cause headaches. Pristiq did nothing for me at all. I gave it a good try, about 6 months or so and nothing. Just blah. I will tell you that the switch from Effexor to Pristiq was seamless, no side effects. I am now taking Cymbalta and I am plumper than ever, thank you Cymbalta!





I would seriously rethink the Cymbalta.....i have now been off of it almost 2 weeks and i am still having the "brain zaps"....they are getting better with each day but they actually make you think you are going crazy...made me really wanna pull my hair out...i have been a nurse for many years and seen many patients come through the ER that was having withdraws from illegal drugs and the Cymbalta made me feel like i was going through the same thing...let me know how you do....

#30 psfws11

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Posted 11 August 2010 - 09:11 PM

I started taking anti-depressants one year ago after years of struggling and trying to hide this disease...clinical depression. I just found out I was vitamin D deficient - more than the average person who lives in a place where seeing the sun is a rarity. I recently started taking 2000mg of vit D as directed by my doctor. This has helped my overall mood tremendously. My craving for certain foods has diminished. As for the meds:

1-From Cylexa - which left me with zero libido but it was incredible to start feeling back to my old self (it'd been a LONG time).
2-To Lexapro - the weight gain began and I felt like Lexapro stopped working after 4 months and felt those old familiar feelings again.
3-My family doctor then added Wellbutrin to Lexapro. The weight seemed to slide off over the first couple weeks, then I started to feel jittery and anxious...literally jumping out of my skin. I was constantly having heart palpatations and for the first time in my life (I'm in my early 30s) I had high blood pressure. I finally went to a psychiatry office, where I saw a physician's assistant. I highly recommend going straight to a highly respected professional if you are going to need medication. When I first went to the Psychiatry office the PA said the dose was too high.
4-So we tried Prozak. Talk about brain zaps. It was like being plugged into an electrical outlet. I cried - a lot.
5-So we tried Cymbalta. It worked! I felt amazing! Completely right. Except....the weight. I have weighed about 130 lbs my whole life. Now I weigh 150. That scale won't budge. I finally started counting calories which helps. But my metabolism is slow and I don't even recognize myself in pictures. Nothing busted more than a pound or two from the scale. My clothes are tight. And I now have cellulite on my arms and my belly. It's like a nightmare...anyone who has been fit their whole life with tight abs and arms who wakes up heavier each day would feel like a different person. This isn't me! It's so uncomfortable. I asked what my options are.
6-So we are trying Pristiq starting tomorrow. Anyone who has recently gone through this please let me know how you are making out.

I wasn't going to post but this site has helped me so much that I wanted to contribute. I don't feel as alone. Many people still think clinical depression is not real. I've heard people say they think it is a weakness. And you know what? Let them talk. I don't ever want anyone to know what it's like. I'd rather hear them criticize me for being on medication, seeing a therapist and being sensitive and overreacting than have them experience this. It's that bad for me...the struggling...the abuse of our bodies - whatever your indulgent pleasure may be - alcohol, smoking, drinking excessive caffeinated/energy drinks everyday or extreme exercising/dieting...it is a lonely, self-loathing, stuck in the past place to be. I am so thankful for these medications and my therapist. You can change. I did.

Edited by psfws11, 11 August 2010 - 09:17 PM.


#31 KayBee01

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Posted 17 August 2011 - 08:12 PM

I started taking anti-depressants one year ago after years of struggling and trying to hide this disease...clinical depression. I just found out I was vitamin D deficient - more than the average person who lives in a place where seeing the sun is a rarity. I recently started taking 2000mg of vit D as directed by my doctor. This has helped my overall mood tremendously. My craving for certain foods has diminished. As for the meds:

1-From Cylexa - which left me with zero libido but it was incredible to start feeling back to my old self (it'd been a LONG time).
2-To Lexapro - the weight gain began and I felt like Lexapro stopped working after 4 months and felt those old familiar feelings again.
3-My family doctor then added Wellbutrin to Lexapro. The weight seemed to slide off over the first couple weeks, then I started to feel jittery and anxious...literally jumping out of my skin. I was constantly having heart palpatations and for the first time in my life (I'm in my early 30s) I had high blood pressure. I finally went to a psychiatry office, where I saw a physician's assistant. I highly recommend going straight to a highly respected professional if you are going to need medication. When I first went to the Psychiatry office the PA said the dose was too high.
4-So we tried Prozak. Talk about brain zaps. It was like being plugged into an electrical outlet. I cried - a lot.
5-So we tried Cymbalta. It worked! I felt amazing! Completely right. Except....the weight. I have weighed about 130 lbs my whole life. Now I weigh 150. That scale won't budge. I finally started counting calories which helps. But my metabolism is slow and I don't even recognize myself in pictures. Nothing busted more than a pound or two from the scale. My clothes are tight. And I now have cellulite on my arms and my belly. It's like a nightmare...anyone who has been fit their whole life with tight abs and arms who wakes up heavier each day would feel like a different person. This isn't me! It's so uncomfortable. I asked what my options are.
6-So we are trying Pristiq starting tomorrow. Anyone who has recently gone through this please let me know how you are making out.

I wasn't going to post but this site has helped me so much that I wanted to contribute. I don't feel as alone. Many people still think clinical depression is not real. I've heard people say they think it is a weakness. And you know what? Let them talk. I don't ever want anyone to know what it's like. I'd rather hear them criticize me for being on medication, seeing a therapist and being sensitive and overreacting than have them experience this. It's that bad for me...the struggling...the abuse of our bodies - whatever your indulgent pleasure may be - alcohol, smoking, drinking excessive caffeinated/energy drinks everyday or extreme exercising/dieting...it is a lonely, self-loathing, stuck in the past place to be. I am so thankful for these medications and my therapist. You can change. I did.



Your post is very informative and I hope you will post how you're doing with the Pristiq. I'm on Celexa and have been for well over a year. Its not helping at all anymore and I think it actually increases my anxiety. I have a lot of agitation. When I first started AD's I was put on Prozac and it was wonderful but over the years it stopped working. I gained 40 lbs taking Prozac and its taken me 10 yrs to get rid of it. I don't want to put it all back on so I understand completely how you feel.
Thanks

#32 justme4689

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Posted 09 September 2011 - 08:58 AM

I have never posted to a forum like this before. To give you some background on myself, I am 32 years old, single mom (divorced three years ago), full time college student (majoring in special education). I graduated HS in 97, and decided not to go to school right away, ended up married, then had my daughter, and thought I would wait to go to school until she was older and in school, the year she was to start K my son was born, so I made the same decision. Finally last October I enrolled in online classes, full time, while also working 50+ hours per week, and maintaining my children's schedules because I refuse to do anything that takes away from their childhood. This was very stressful and created the problem of no sleep for me, because I would only work on my school work when they were sleeping at night. I maintained perfect grades and all that. I should also include that upon moving back to my home state of Arkansas after my divorce I soon began datiing my best friend's younger brother, we have been together for a little over two years. Obviously having known his family my entire life I have always been very close with them. His father passed away March 2010 of pancreatic cancer, which devasted not only him and his family, but also my children and I (as they had gotten very attatched to him). Then December of 2010, his grandmother also passed away, which further depressed me, then February of this year my grandmother passed away, I assisted in her care during her final days at home... as if all of that wasn't enough, I lost my job in April, had to move into a tiny apartment, and figure out how to make it with very little income. The first week of June my children left to spend the summer with their father who lives in another state. I had never been away from them longer than Christmas Break and sank further into depression. My daughter had a very hard time being away from me, and decided at the end of July to come home. My son (who is 6) told me after she came home that he wanted to live with his dad. I had always promised both of them that if they ever decided that is what they wanted to do, that I would let them. I never wanted them to feel that they were "stuck" with me, or that they were caught in the middle. My son had no memories of his father since he was so young when we separated, and didn't have a "real" bond with him. I was totally destroyed by his decision, but I did not let him know that, I didn't want to make him feel bad, so I told him that if that's what he wanted, then I would let him, that I wanted him to be where he felt he would be happiest, and that I would love him the same no matter where he lived. I pushed everyone away, except my daughter (11) whom I clung to, I didn't want to be away from her for a second. I would go days without leaving the house, or speaking to anyone other than her (not even my boyfriend). I would make up excuses to not have people come to my house, I didn't eat, didn't sleep, didn't do anything, I just wanted to stay in my bedroom and hide from the world. I cried nonstop, I couldn't sleep for all of the anxiety over things that might happen if I weren't with my son. I was consumed by my depression and by my anxiety. I finally realized that it was time to see the doctor.

My doctor put me on cymbalta for the depression and an anxiety medication to use at night so that I would sleep. The cymbalta gave me a headache for the first week or so, caused hot flashes, nausea, and all of those other nasty side effects. After two weeks I went back for my follow up, he decided to increase the dosage and since I still wasn't sleeping, he took out the anxiety medication and placed me on ambien, and told me to come back in a month. After the initial side effects from the cymbalta subsided, I did stop crying all of the time, and I lost about 15 pounds. However, I still wasn't me. I would go places if I were forced to, and talk if someone MADE me speak, otherwise, I still sat trapped inside my head with my thoughts, and instead of feeling sad, I just felt blank. I had no mood at all. I still made excuses to keep people from coming over, and still had to force myself to get up, take a shower, and still would generally just put pajamas back on. Finally it was time for another follow up, which was good because I was also sick.

Tuesday (the day after Labor Day) I went back to the doctor with a horrible sinus and ear infection (which I am very prone to) this was the worst ear infection I have ever had, the pain was off the charts. I told him about my mood, and that I still wasn't sleeping (even taking benadryl with ambien didn't allow more than 2-3 hours per night). He said it was time to try something different, that he WAS going to make me feel better, and that I WOULD be me again.

He gave me samples of Pristiq and of Lunesta (along with a Zpack for the infection). I started taking Pristiq that day (I had forgotten to take my cymbalta that morning). I took it around 1 PM that day. I got a horrible headache, my ears were ******* me (to the point that as I layed in bed I prayed for my ear drums to rupture just to get some relief) and I guess due to the combo of pain and taking the Pristiq that late in the day, even with nighttime cold medication, and the lunesta I did not sleep at all that night. The following day I still had the same problems with headache and ear pain, but I took the Pristiq at 6 AM when I got my daughter up for school. I was still in a great deal of pain that night, but took the Lunesta and only tylenol and motrin for the pain and was able to sleep, and I slept ALL night.

Yesterday was day 3 on Pristiq, and I felt much better, no headache, and the antibiotics were finally working their magic on the infection. I actually got up, took a shower, got dressed and went "window shopping" because I WANTED to be out of the house. I also had conversations with people, and had company over to my house.

Today, day 4... I must say I feel AMAZING! I woke up after a full nights sleep, went outside and talked to neighbors, I've talked to people more today than I have in months, and I feel... brace yourself.... HAPPY, and GOOD. I am so excited about how well this medication is working for me, I hope that it continues, I am ready to be ME again, and for the first time in a very long time, I can see that it is very possible.

I am hoping that the weight loss continues on Pristiq like with the cymbalta. But I am just so excited about all of this. Yes, there were side effects from coming off of cymbalta (I believe that's what the headache was from) but I am just thrilled with how I feel now. I am even going on vacation! I leave to go to the beach for 4 days tomorrow, and I'm excited! Not just that, I'm excited about being excited LOL.

I know that things can happen and medications stop working. I was misdiagnosed as being Bipolar when my son was an infant and was placed on lots of various medications, in reality I have ADHD, but the other medications (the wrong ones) that I had taken in the past killed my thyroid, so now my daily medications include Synthroid, Adderall, Pristiq, Lunesta, and Cingulair. I know that I will get better, I also know that there will still be bad days, but I finally feel like I can handle it.





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