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Ronnie

Wellbutrin and SSRI combo

59 posts in this topic

Posted

Hi. I have been on 400mg Wellbutrin and 50 mg Celexa for almost two years. I need the Celexa for my OCD and various anxieties. For me the combo has worked well after trying about 7 other ADs.

Katie

I have been on paxil for the last eight months and have gained 10 pounds. My doc has put me on 100 mg of wellbutrin to see if I can shed a few pounds. Has anyone had good success with this and weight loss?

Newbie

After months of feeling non-sexual on an SSRI, adding the Wellbutrin has helped.  Both with Orgasm and sexual desire.

Ronnie

I started out with Celexa - worked my way up to 40mgs a day and then we added the Wellbutrin SR to help with the binging and other unhealthy impulse reactions (we won't go there!! LOL) The WBSR was a great addition. I still have to make the correct food choices, but the hunger isn't there as much, and things just seem a whole lot more real than it has in the past few years. Currently I'm on 40mgs of Celexa and 400mgs of WBSR.

I'm happy and feel alive.

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Posted

??? Has anyone been on Wellbutrin + Lexapro? WEllbutrin has made me an angry/anxious/mean person. I'm not crying anymore - but I amnot a nice person to be around. My dr added !0mg Lexapro to my 150mgWellbutrin XL. Just wondering if anyone has tried this and if it helped with the side effects. HE actually wanted to double the Wellbutrin! I couldn't do that!

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Posted

I am on both Lexapro and Wellbutrin.  If it wasn't for the Lexapro, there would be no-way I could handle the Wellbutrin's anxiety, aggitation side effects.

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Posted

Ronnie,

Always one to be right on top of things <sound of foghorns in the distance> I missed your post here until I was browsing through just now.

...things just seem a whole lot more real than it has in the past few years... I'm happy and feel alive.
I'm so happy for you!

mccashman,

I hope you find this encouraging. I think you showed good judgement in choosing not to increase the WB at this time. There are lots of people who've done well on combinations of meds, like WB and an SSRI. Adding an anti-anxiety med to help with the start-up effects is another approach. Hang in there - it takes patience to find what works for you, but it's worth it.

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Posted

:) Is it actually possible that after three days with the 10mgs of Lexapro added that I am already feeling better? Happy, laughing, reaching out ot people I have been avoiding and not angry/mean anymore! Hope it's not a placebo effect!

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Posted

Mcashman - it could very well be real effects, not just placebo! Lexapro is supposed to "kick in" faster than the others and many people notice a difference in the first week. (I didn't notice a difference at all after taking it over a month, but I am just not having luck with antidepressants in general!) I'm glad you're feeling better - enjoy it!

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Posted

Are there any SSRI's that are more complimentary as a combo with WB or doesn't it matter? (ie. Whatever works for you.) One I have considered is effexor but would that be bad with the WB because they both lower the seizure threshold?

The reason I ask is because it is likely I may need to add an SSRI to the WBSR I'm currently taking. I want to know which SSRI that overall people have found to have the least weight and sexual s/e's. Those two issues are very imortant to me because my depression is linked to sexual issues and I cannot bear to have a medicine in additional to my pysch makes things worse. I'm trying to get better here. I already suffer from reduced sensation due to dissociation. I don't want anything to make it worse. Weight gain will also be difficult for me because of other/marital issues. I'm so sad. I want to be normal again and I'm afraid I never will be.

Please, anyone who has found a good WB/SSRI combo, share!

(P.S.- I've been on the WB 3 weeks on full dose, a month including the first week at 1/2 dose. I have not had any increase in libido :( and it has not affected my appetite at all. I don't need to lose any weight so that's fine but I definitely don't want to gain.)

I'm just sad and scared about not ever getting better and making things worse trying to treat it. Please advise.

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Posted

mcashman--I also felt better by day 3 on Lexapro.  I started it b/cause I had been on WB for over 2 yrs. and it pooped out.  But I continued to take WB to hopefully deal with the se of sexual disfunction with Lexapro.  I'm feeling better than I have in a long time.  Unfortunately the sexual se's are there.  

Jaded--I've actually had less of an appetite since adding Lexapro.  I feel real good but unfortunately have sexual se's.  It's so hard to have everything perfect.  But as some here have said, after a long time it might go away.  I've only been on Lexapro for 5 weeks.  So I'm going to wait it out.  You have to weigh the benefits against the se's sometimes.  I've been told that Effexor also has sexual se's.  We all act differently so it's hard to say how each person will be.

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Posted

Jaded,

Try to be patient - you may not feel the full effect of the WB for a while, sometimes for up to 12 weeks.

If you do need to add an SSRI, there are lots of different combinations that have been successful for others. It takes some trial and error. But in combo with the WB, you might not experience the side-effects of weight gain or sexual problems - everyone responds differently.

Let us know how you're doing, and post here for support.

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Posted

I am still doing well on my combo of Wellbutrin and Celexa.  I had a severe manic episode this spring which made me have to discontinue the Celexa temporarily.  Now I am just taking a small pinch, 20 mgs with the normal 400 Wellbutrin SR.  The Wellbutrin helps with the sluggishness and increased appetite from Celexa.  Just thought I would update.

Katie :;):

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Posted

I am wondering how long people usually wait before discontinuing the WB or adding an SSRI. I keep reading "up to 12 weeks" for WB to take effect. I am entering week 5, and feel horrible. The SEs (anger, insomnia) have gotten better, but am still crying almost daily, and feel worthless/hopeless, no sex drive. Am seeing new doc next week, and not sure if I should try to wait out the WB alone, or ask for her to add SSRI. I am also terrified of weight gain, and unfortunately have not had the side effect of decreased apetite with WB. Would appreciate any suggestions..Thanks!

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Posted

Just got back from my pdoc appt.  We've decided to drop back down to 150mg of Wellbutrin (also down to 10mg Lexapro from 15mg).  Had some continued side effects after increasing it to 300mg about 5-6 months ago.  I figured this was long enough to see if the benefits outweighed the side effects.  Got to disorientated on that dosage.

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Posted

Jaded,

Try to be patient - you may not feel the full effect of the WB for a while, sometimes for up to 12 weeks.

If you do need to add an SSRI, there are lots of different combinations that have been successful for others. It takes some trial and error. But in combo with the WB, you might not experience the side-effects of weight gain or sexual problems - everyone responds differently.

Let us know how you're doing, and post here for support.

Thank You Lizard. I need all the advice and support I can get...

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Posted

I just started Wellbutrin SR this week. I'm on 150mgs of the wellbutrin, 12.5mgs of paxil cr, 10mgs of lexapro...down from 20mgs I'm not sure if my pdoc is taking lexapro away or not, and 100mgs of geodon going down to 80mgs soon...she also took away my 75mgs of nortriptyline. I just started the paxil cr when I started the wellbutrin and I decreased my other meds at the same time so I don't know if I'm having side effects from the new pills or if it's from decreasing the other ones.  I got a new pdoc and she's changing everything. lol. I have panic disorder and so far I haven't noticed any extra anxiety so that's a plus. I'm hoping the wellbutrin will help me lose some weight and give me some extra energy. I'm pretty sure she's going to increase my dosage of wellbutrin and was wondering if any of you thought that might cause the anxiety SE to pop up. Like I said I don't have it yet so I'm crossing my fingers it won't be a problem.

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Posted

Whew, Tanha, that's a lot of changes!

Hopefully, you and your new doc will have found the right meds for you to feel well.

If your doc suggests upping the dosage of WB, talk to her about your concerns. There are lots of options for tweaking the medications.

I'm glad you're not having increased anxiety, and I'll keep my fingers crossed along with yours, that it continues to go well.

Let us know how you're doing...

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Posted

I have a question:  Since St John's Wort acts like an SSRI, is it safe to take with Wellbutrin?  I had good results on SJW about a year ago and am considering additing it to WB and eventually switching since it's much cheaper and I'm out of work.  :confused:    However I've read elsewhere that you shouldn't mix SJW with prescription anti-depressants including SSRI's and WB.  Any thoughts on this?  I will of course talk to my doctor about this as well.  :suspect:

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Posted

St. Johns wort has been proven to be somewhat effective.  And even prescribed in Europe. I think it acts like a MAOI, but not sure.  

Although, since there are different brands out there and you never know how much of the real stuff is actually in the pill.... i'd use caution.  GNC has a brand that is taken once a day (500mg I think).  i've never heard of anyone taking it with Wellbutrin.  Talking to your doc would be good, but most doc's won't know much about them.  Talk to a herbologist or Health food herbal person or someone like that if you can.  But they will also tell you not to mix it, especially with an SSRI since most labels will say the same thing.

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Posted

Hello All ..I'm new here. Need some help.

I've been on Lexapro for 8 months for anxiety and panic attacks, it's worked great for me. I also take Ativan as needed. Lex is the only anti-depressant I could stay on for longer than 3-4 days. I was getting concerned because I've gained about 25 pounds in 8 months. I started at 5'8 120. I have always been thin. So I've never even thought of dieting. I've tried that AND exercise- NOTHING... I feel fat . I want my body back.. And I have 0 sex drive UGH.

I went to my MD today and she said I should try adding Wellbutrin to the Lex. it's supposed to help lose weight and improve sex drive!! I am afraid to take ANOTHER med on top of Lex!?!?!? Plus she gave me "regular" Wellbutrin 75 mg not the SR or XL, because she only wants me to take it in the morning and hopefully it will wear off at night so I can sleep... Anyone have any advice??? I'm not sure what to do?????

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Posted

Lexapro and Wellbutrin is a good combination.... a lot of us are on it (including myself).  It should help with the weight and definitely help with your sex drive if your a female.

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Posted

Ronnie,

It's been a while since I posted.

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Posted

gryphon,

I know you addressed your question to Ronnie, but I thought you might want to peek in on 2 archived links to PMS/PMDD:

http://www.depressionforums.com/forum....102;hl=

http://www.depressionforums.com/forum....403;hl=

I'm aware of Prozac being prescribed on occasion for PMS for just one week of each month, but I don't have personal experience with this and don't know how effective it is.

I found the WB had very hormonal side-effects for me, and worsened my PMS. A little anti-anxiety med, like a benzo, on an as-needed basis helped a bit with the agitation.

Good luck!

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Posted

gryphon,

I know people who take a low dose of Paxil as needed for anxiety and/or stop for a day or two if they want to have an "O".  I'd think Zoloft would be able to work this way due to its short half life.  I'd definitely talk to your doc about trying Zoloft only during the PMS phases each month, the only problem is possible start up and withdrawal side effects each time.

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Posted

I have a couple questions....

I started on Zoloft a week and a half ago. Am up to 50mg a day now and moving up to 100mg in a week. So far I have actually felt a small increase in libido since starting Z and no increase in appetite. I am also at this time weaning off WBSR. I was on it for 9 weeks with no improvement...even more breakdowns if that's possible...and no positive effects from the WB. No increase in sex drive and no appetite decrease.

My first question is if I didn't experience those positive effects on the WB and I have weight/sex s/e issues develop on an SSRI will adding WB back do anything for me? Seems like if it didn't help with any of that by itself I shouldn't expect it to have any effect countering something else.

Second question - How long after starting an SSRI would I notice sex/weight s/e's developing?

What are your thoughts?

(p.s. I am feeling more even after 1 1/2 weeks on Z than I did in 9 weeks on WB. I still have a LONG way to go before I feel truly good but haven't had a single breakdown and just feeling overall more emotionally even. :)

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Posted

Gryphon, I am not sure that taking an SSRI for a week every month would be worth it.  Since most of these meds only work after many weeks, they may not have an impact for just that week.  The next month would be like starting over.  I had an ob/gyn once suggest I increase my Celexa dosage just for that week and then return to the normal dose.  I never tried it, but I thought it would be a bumpy transition going up and coming down.

Katie :)

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Posted

Hi,

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