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  Nov 3 2007, 11:05 PM
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Member
Group: Member
Posts: 165
Joined: 8-August 07
From: Seattle
Member No.: 18,117
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There's a recent article out about this particle antipsychotic, stating that it's been found to be helpful for treatment-resistent depressives, like myself, and for bi-polar. I'm posting the article below. Has anyone used this drug for any purpose, and found it effective?
Antipsychotic Drug May Help Treat Depression
Study: Drug, Called Risperdal, May Ease Depression In People Who Don't Respond to Antidepressants
By Miranda Hitti
WebMD Medical NewsReviewed by Louise Chang, MDNov. 2, 2007 -- The antipsychotic drug Risperdal may ease depression in patients who don't respond to antidepressants, a new study shows.
The study, published in the Annals of Internal Medicine, included about 274 depressed adults (average age: mid-40s) who had been depressed for nearly 17 years.
At the study's start, the patients took various antidepressants for four weeks. But their depression didn't lift.
The researchers split the patients into two groups. One group took Risperdal for six weeks. The other group took a pill containing no medicine (placebo). All patients continued their regular antidepressant medication.
Six weeks later, depression was in remission for about 24.5% of the Risperdal patients, compared with almost 11% of those taking the placebo.
Patients taking Risperdal were also more likely than those taking the placebo to have their depression symptoms ease to a lesser extent.
The most commonly reported adverse events were:
Headache (nearly 9% of Risperdal patients and about 14% of those taking the placebo)
Sleepiness (5% of the Risperdal patients and almost 2% of those taking the placebo)
Dry mouth (5% of the Risperdal patients and nearly 1% of those taking the placebo)
The study also included a six-month follow-up to see if Risperdal helped prevent depression relapse.
Risperdal isn't approved by the FDA for depression treatment. It's approved for treating three conditions:
Schizophrenia in adults and adolescents aged 13-17
Short-term treatment of manic or mixed episode of bipolar disorder for people who are at least 10 years old
Irritability in autistic children and teens aged 5-16
With regard to Risperdal, "the benefit of continuing longer-term treatment for patients who achieve remission is uncertain but may be limited to those with the least response to their initial antidepressant treatment," write the researchers.
The study was funded, designed, and supervised by Janssen Pharmaceutica, which makes Risperdal. The researchers, who included Ramy Mahmoud, MD, MPH, work for Ortho-McNeil Janssen Scientific Affairs. Ortho-McNeil and Janssen are both subsidiaries of Johnson & Johnson.
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I see in your eyes the same fear that would take the heart of me. A day may come when the courage of men fails, when we forsake our friends and break all bonds of fellowship, but it is not this day. An hour of woes and shattered shields, when the age of men comes crashing down! But it is not this day! This day we fight! By all that you hold dear on this good Earth, I bid you stand, Men of the West!
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Replies
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Nov 4 2007, 11:17 AM
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Advanced Member
Group: Advanced Member
Posts: 255
Joined: 21-September 07
Member No.: 19,158
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QUOTE (May_It_Be @ Nov 3 2007, 11:05 PM)  There's a recent article out about this particle antipsychotic, stating that it's been found to be helpful for treatment-resistent depressives, like myself, and for bi-polar. I'm posting the article below. Has anyone used this drug for any purpose, and found it effective?
Antipsychotic Drug May Help Treat Depression
Study: Drug, Called Risperdal, May Ease Depression In People Who Don't Respond to Antidepressants
By Miranda Hitti
WebMD Medical NewsReviewed by Louise Chang, MDNov. 2, 2007 -- The antipsychotic drug Risperdal may ease depression in patients who don't respond to antidepressants, a new study shows.
The study, published in the Annals of Internal Medicine, included about 274 depressed adults (average age: mid-40s) who had been depressed for nearly 17 years.
At the study's start, the patients took various antidepressants for four weeks. But their depression didn't lift.
The researchers split the patients into two groups. One group took Risperdal for six weeks. The other group took a pill containing no medicine (placebo). All patients continued their regular antidepressant medication.
Six weeks later, depression was in remission for about 24.5% of the Risperdal patients, compared with almost 11% of those taking the placebo.
Patients taking Risperdal were also more likely than those taking the placebo to have their depression symptoms ease to a lesser extent.
The most commonly reported adverse events were:
Headache (nearly 9% of Risperdal patients and about 14% of those taking the placebo)
Sleepiness (5% of the Risperdal patients and almost 2% of those taking the placebo)
Dry mouth (5% of the Risperdal patients and nearly 1% of those taking the placebo)
The study also included a six-month follow-up to see if Risperdal helped prevent depression relapse.
Risperdal isn't approved by the FDA for depression treatment. It's approved for treating three conditions:
Schizophrenia in adults and adolescents aged 13-17
Short-term treatment of manic or mixed episode of bipolar disorder for people who are at least 10 years old
Irritability in autistic children and teens aged 5-16
With regard to Risperdal, "the benefit of continuing longer-term treatment for patients who achieve remission is uncertain but may be limited to those with the least response to their initial antidepressant treatment," write the researchers.
The study was funded, designed, and supervised by Janssen Pharmaceutica, which makes Risperdal. The researchers, who included Ramy Mahmoud, MD, MPH, work for Ortho-McNeil Janssen Scientific Affairs. Ortho-McNeil and Janssen are both subsidiaries of Johnson & Johnson. Well, i do not know anything about Risperidone...  i just wanted to tell you i love your signature.
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Nov 4 2007, 04:14 PM
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Member
Group: Member
Posts: 165
Joined: 8-August 07
From: Seattle
Member No.: 18,117
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QUOTE (Christopher @ Nov 4 2007, 09:17 AM) Well, i do not know anything about Risperidone... i just wanted to tell you i love your signature. LOL. Well, thanks anyway! 
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I see in your eyes the same fear that would take the heart of me. A day may come when the courage of men fails, when we forsake our friends and break all bonds of fellowship, but it is not this day. An hour of woes and shattered shields, when the age of men comes crashing down! But it is not this day! This day we fight! By all that you hold dear on this good Earth, I bid you stand, Men of the West!
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Nov 5 2007, 01:41 AM
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Member
Group: Member
Posts: 165
Joined: 8-August 07
From: Seattle
Member No.: 18,117
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QUOTE (May_It_Be @ Nov 4 2007, 01:14 PM) QUOTE (Christopher @ Nov 4 2007, 09:17 AM) Well, i do not know anything about Risperidone... i just wanted to tell you i love your signature. LOL. Well, thanks anyway! Come now, someone must have some info! Please?
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I see in your eyes the same fear that would take the heart of me. A day may come when the courage of men fails, when we forsake our friends and break all bonds of fellowship, but it is not this day. An hour of woes and shattered shields, when the age of men comes crashing down! But it is not this day! This day we fight! By all that you hold dear on this good Earth, I bid you stand, Men of the West!
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Nov 12 2007, 01:53 PM
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Newbie
Group: Newbie
Posts: 14
Joined: 10-November 07
Member No.: 20,417
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QUOTE (May_It_Be @ Nov 5 2007, 01:41 AM) QUOTE (May_It_Be @ Nov 4 2007, 01:14 PM) QUOTE (Christopher @ Nov 4 2007, 09:17 AM) Well, i do not know anything about Risperidone... i just wanted to tell you i love your signature. LOL. Well, thanks anyway! Come now, someone must have some info! Please? Yes, my doctor gave it to me with Zoloft. I was really depressed and tried two other antidepressants which were not working. The moment I switched to Zoloft and Risperdal I noticed a change. However, I am not taking that combination anymore. I am not sure if it is still working and dont want to increase because I want to go off of it. My problem with Risperdal is that it has decreased my interest in everything as well as my motivation to do anything. But that's just me as for an add on to Zoloft it really helped my depression at the time. It also calmed down my crazy side, which I really miss! Being bipolar you might understand that manic high. I dont know if everyone likes it but I did. Good Luck
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Risperdal (risperidone), Anyone have experience with this med? |
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Depression Forums - A Depression & Mental Health Community Support Group > DEPRESSION & ANXIETY MEDICATIONS - LOOKING FOR ANSWERS > OTHER DEPRESSION & ANXIETY MEDICATIONS
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