Looking at the Mirt/Remeron forum I see a lot of negative threads. I was a little concerned in case a newcomer was to look into the forum for some hope. My story:

About six years ago I started feeling funny. I couldn't think of anything good to do and I felt like I was robbing a bank vault and the cops were coming towards me thru the lobby; serious anxiety. I had no idea what these feelings were and they caused me to really worry, such that I went to the Dr. I explained my problem and he attached a heart monitor to me for a 24 hour period to see why my heart was racing. My new anxiety/depression (unknown at that time) was causing me to worry such that I would hyperventilate and my heart would do strange things. I had NO idea it was happening in the brain. Obviously nothing came from the heart check or the full blood check. After about two weeks of this, with the dep/anx steadily increasing my dr. deduced that I might be suffering from depression. I had been losing large amounts of sleep and could barely function. I thought I would be admitted to an insane asylum for the rest of my life. My attacks would last very long because my reaction would trigger another attack. When I did sleep after exhaustion I would wake up in the middle of a panic attack. Life was not good.

So my dr put me on Remeron. I think around 7.5 or 15. RELIEF!!! Finally some moments of relief. But it didn't fix it all the time, only around night time. Oh the wonder of medication!!! Then he put me on Effexor but that didn't seem to do anything, so I begged to be taken off that. I think I made it to 30 mg of Remeron before he said that he couldn't legally prescribe anything higher and I should go to a psychiatrist. Well that just wasn't going to happen. Not me. I put that off as long as I could but then after I started singing Tiptoe thru the Tulips and liking it, I went. My new psych dr was a no nonsense guy. No compassion on the surface but very knowledgeable and not afraid of the hype. He listened to me telling everything I could, asked brilliant questions. When it was said and done I was on 300 mg of Effexor XR and 50 mg or Remeron and feeling completely like I was used to feeling. I felt so normal that I have often wondered if my dep/anx has left me.

My point is not to write a pamphlet. My intention is to say that Remeron was the med that finally gave me some relief. And as my dr increased it I felt confident that I would sleep peacefully. And I did.

I am to a point that I am coming off Remeron but staying on Effexor.

Please remember, there's always hope and there are combos of meds that should allow you to find relief. Hang in there!!!