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post Aug 4 2006, 07:07 PM
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QUOTE
Genetic Findings Shed Light on OCD
08.03.06, 12:00 AM ET

THURSDAY, Aug. 3 (HealthDay News) -- A newly identified genetic factor may explain how and why obsessive-compulsive disorder (OCD) runs in families, two new studies conclude.

Close relatives of people with OCD are up to nine times more likely than other people to develop OCD.

The two studies, published in the current issue of the Archives of General Psychiatry, found an association between OCD and a glutamate transporter gene called SLC1A1. The gene encodes a protein called EAAC1 that regulates the flow of glutamate in and out of brain cells. Variations in the SLC1A1 gene may cause changes in the flow of glutamate, which may put a person at increased risk of developing OCD, the researchers suggested.

One study was conducted by researchers from the University of Michigan, the University of Illinois at Chicago, and the University of Chicago. That study included 71 OCD patients (children and adults) and their parents.

The other study, by University of Toronto researchers, included 157 OCD patients and 319 of their first-degree relatives.

"Taken together, these findings suggest that SLC1A1 is a strong candidate gene for OCD, which if confirmed could lead to improvements in understanding and treating this condition, and screening those with an elevated risk," Dr. Gregory Hanna, senior author on one of the studies and an associate professor of psychiatry at the University of Michigan Medical School, said in a prepared statement.

"It's possible that altered glutamate activity in some brain regions may contribute to the obsessions and compulsions that are the hallmark of OCD," Hanna said.

More information
SOURCE:- University of Michigan Medical School, Forbes
The American Medical Association has more about OCD.


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Lost74
post Apr 16 2007, 12:13 AM
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OCD runs rampant in my family. We even participated in a research study because of this. My dad, sister, aunts, and uncles all have it. So I strongly believe in a genetic connection.


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fem 32 uk
post Jun 18 2007, 06:01 AM
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QUOTE(Lost74 @ Apr 16 2007, 12:13 AM) *
OCD runs rampant in my family. We even participated in a research study because of this. My dad, sister, aunts, and uncles all have it. So I strongly believe in a genetic connection.

hi yes in my familly too differents sorts,me and my sisters have had harm thoughts towards love ones which is soul destroying!!
my uncle as it the way he as to put things all in a certain way or it drives him mad.
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Niobe
post Aug 5 2007, 01:49 PM
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I fully believe it is a genetic and biological disease. I have it, and my dad and one of his brothers were very rigid, compulsive-type people--not full-blown-OCD like me but it's like they had it in an attenuated form. I think it definitely comes from my dad's side of the family--and their mom (my paternal grandmother) suffered life-long depression and was very obsessive about her health and some other things. So yes, I think it runs in families. Oddly, my dad's other brother and his sister don't seem to have it. I guess they got lucky!!! :)

My dad also seems to have a mild form of Tourette's--clearing his throat, making involuntary gestures, twitching, grimacing, mild things like that. So I think that's a part of it too.

Very interesting info, thanks for posting it--it only reinforces my own family observations!!


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blueboy101
post Nov 5 2007, 01:31 PM
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Hi guys my name is kieran and this is my first post on this forum. The article posted is very intirguing indeed. I was diagnosed with a mild form of ocd about 5 years ago. My ocd mainfests itself all in my mind and is so frustrating. I often have obsessive thoughts that I'm not good enough and that I may harm myself or others. I had another episode in the summer as i was working as an accounting intern and got so obsessed that I was always making mistakes and was not good enough - this then took me into a depression which i am still in just now.I am now in my 4th year of university and find it so hard to concentrate and am thinking about dropping out because my confidence is so low. My father and grandfather had clinical depression and i think the gene has been passed onto me. I have been clinically depressed 3 times in my life( this being my third) and am trying to desperately get a system for dealing with it. I have been on and off 40mg of citalopram since i was first diagnosed with ocd and from speaking to my father i now realise that i need to stay on this drug otherwise i will get obsessive about things again which will lead to depression. I am also seeing a therapist although recently have been so desperate to get a 'cure' that i have been going to phychics/ hypnotherapists etc - none have worked. Can i ask how you guys deal with you ocd? My father has not actually been disgnosed with ocd but has had depression - he tells me to excercise etc and just now i am doing all these things but find it difficult to get a grip and get on with things.

p.s. apologies for the long post and for me gushing my heart. Myt intention in the next couple of posts is to reply to others suffering not just bleat on about mine but i thought this would be a good starting point.

cheers
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Digging Fool
post Aug 18 2009, 10:50 PM
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QUOTE (Lost74 @ Apr 16 2007, 12:13 AM) *
OCD runs rampant in my family. We even participated in a research study because of this. My dad, sister, aunts, and uncles all have it. So I strongly believe in a genetic connection.
My father and an uncle have it, but I think I got the worst case of it.........


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