Advertisement
|
|
 |
|
 |
 |
|
|
|
|
|
|
|
|
 Aug 18 2008, 12:40 AM
|
Silver Member
Group: Silver Member
Posts: 948
Joined: 19-March 08
From: South Africa
Member No.: 23,704
|
Remeron is not a selective serotonergic antidepressant, It is a serotonergic - noradrenergic reuptake inhibitor. It does work on selective serotonin and noradrenalin receptors. In addition it acts on other receptors as well, blocking some of them
It's extremely difficult to determine that "serotonin is the problem" as other things can also be a problem, there are knock-on effects, and many receptors involved. If only we had tests that could say 'You have a problem with receptors x, y, and z - this is the med you need" ... well... that would be utopia.
--------------------
"Out of the night that covers me,
Black as the Pit from pole to pole,
I thank whatever gods may be
For my unconquerable soul.
.....
It matters not how strait the gate,
How charged with punishments the scroll,
I am the master of my fate;
I am the captain of my soul." - "Invictus" (abbreviated), William Ernest Henley, 1875
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 18 2008, 04:39 AM
|
Silver Member
Group: Silver Member
Posts: 957
Joined: 3-September 07
From: Wales
Member No.: 18,703
|
QUOTE (moonlightress @ Aug 18 2008, 06:40 AM)  Remeron is not a selective serotonergic antidepressant, It is a serotonergic - noradrenergic reuptake inhibitor. It does work on selective serotonin and noradrenalin receptors. In addition it acts on other receptors as well, blocking some of them
It's extremely difficult to determine that "serotonin is the problem" as other things can also be a problem, there are knock-on effects, and many receptors involved. If only we had tests that could say 'You have a problem with receptors x, y, and z - this is the med you need" ... well... that would be utopia. How cool would that be? Blood test to see what your problem was and then med to fix it. Even better, one that worked within a day !!!!! :-)
--------------------
"Every day when I wake up I thank the Lord I'm Welsh" - Catatonia
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 18 2008, 11:21 AM
|
Junior Member
Group: Junior Member
Posts: 108
Joined: 28-May 08
From: India
Member No.: 25,593
|
QUOTE (moonlightress @ Aug 18 2008, 11:10 AM) Remeron is not a selective serotonergic antidepressant, It is a serotonergic - noradrenergic reuptake inhibitor. Noooooooooooooooooo.  Mitz. is not a SRI. It blocks the channels that inhibit the production of serotinin (and nonadrenaline). Thus more serotin is generated. Although the end results of Mitz. and a SRI are the same, they both work from opposite ends. This is one of the reasons why Mitz. is considered in treatment resistant depression where SSRI's have failed.
This post has been edited by Rahul: Aug 18 2008, 11:43 AM
--------------------
I'm not a doctor or a health professional and any advice in my post is purely my personal opinion.
Dx: MDD
Rx: 10 mg escitalopram + 15mg mitrazapine + 0.5mg clonazepam at bedtime
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 18 2008, 11:31 AM
|
Junior Member
Group: Junior Member
Posts: 108
Joined: 28-May 08
From: India
Member No.: 25,593
|
QUOTE (Robert123 @ Aug 18 2008, 09:06 AM) Remeron is a specific serotonergic antidepressant. Remeron releases serotonin and it has the unique ability to block two specific serotonin receptors. I personally don't know if that's a good thing or bad. If serotonin is the problem/answer is Remeron serotonin actions be as effective as a ssri?Thanks What follows is a layman's analysis. If your problem lies in the production of serotinin -- say the serotinin-production inhibitors are working overtime -- then blocking their reuptake will not be so effective as there is anyway too little serotinin in circulation. Consider that maybe because of the less serotin in circulation, your body has already regulated serotin reuptake to be minimum, thus rendering SSRIs redundant. If you can release/produce more serotinin (as Mitz. does), that would make a difference. So if one doesn't work, it's worth trying the other with these two classes of meds.
This post has been edited by Rahul: Aug 18 2008, 11:44 AM
--------------------
I'm not a doctor or a health professional and any advice in my post is purely my personal opinion.
Dx: MDD
Rx: 10 mg escitalopram + 15mg mitrazapine + 0.5mg clonazepam at bedtime
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 20 2008, 10:51 AM
|
Silver Member
Group: Silver Member
Posts: 948
Joined: 19-March 08
From: South Africa
Member No.: 23,704
|
QUOTE (Rahul @ Aug 18 2008, 06:21 PM) Noooooooooooooooooo. Mitz. is not a SRI. It blocks the channels that inhibit the production of serotinin (and nonadrenaline). Thus more serotin is generated. I apologise. You're right, Robert and Rahul. It's classified as an adrenergic agonist which is not the same as a reuptake inhibitor. Well, I learned something new!
--------------------
"Out of the night that covers me,
Black as the Pit from pole to pole,
I thank whatever gods may be
For my unconquerable soul.
.....
It matters not how strait the gate,
How charged with punishments the scroll,
I am the master of my fate;
I am the captain of my soul." - "Invictus" (abbreviated), William Ernest Henley, 1875
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 20 2008, 12:13 PM
|
Junior Member
Group: Junior Member
Posts: 60
Joined: 27-December 06
Member No.: 12,865
|
QUOTE (moonlightress @ Aug 20 2008, 10:51 AM) QUOTE (Rahul @ Aug 18 2008, 06:21 PM) Noooooooooooooooooo. Mitz. is not a SRI. It blocks the channels that inhibit the production of serotinin (and nonadrenaline). Thus more serotin is generated. I apologise. You're right, Robert and Rahul. It's classified as an adrenergic agonist which is not the same as a reuptake inhibitor. Well, I learned something new! It's cool moonlightress. I just don't know if i should up the dosage or change. I sleep still around 12 hours a day and spend the whole day, fatigued and awkward.
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 20 2008, 12:49 PM
|
Junior Member
Group: Junior Member
Posts: 108
Joined: 28-May 08
From: India
Member No.: 25,593
|
QUOTE (Robert123 @ Aug 20 2008, 10:43 PM) I just don't know if i should up the dosage or change. I sleep still around 12 hours a day and spend the whole day, fatigued and awkward. What other meds. are/were you on and what's your diagnosis (depressive, anxiety related et al). I've been on mitz. for over two months now and still sleep 9 to 10 hrs. a day. I would still not trade it for anything else for the quality of sleep is amazing and I feel really good whole day. The feeling of tiredness does wear off. Now I don't feel sleepy or groggy after taking mitz. -- I just fall asleep whenever I decide to. It would not be a lie to say I live to sleep -- I look forward to sleeping.
--------------------
I'm not a doctor or a health professional and any advice in my post is purely my personal opinion.
Dx: MDD
Rx: 10 mg escitalopram + 15mg mitrazapine + 0.5mg clonazepam at bedtime
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 21 2008, 01:46 AM
|
Silver Member
Group: Silver Member
Posts: 948
Joined: 19-March 08
From: South Africa
Member No.: 23,704
|
QUOTE (Robert123 @ Aug 20 2008, 07:13 PM) It's cool moonlightress. I just don't know if i should up the dosage or change. I sleep still around 12 hours a day and spend the whole day, fatigued and awkward. Robert - What dose are you on? It's said to be less fatigueing at 45-60mg. I was only ever at 15mg and I was an eating-sleeping machine. I felt good, though! (Until I got back on a scale, that is.)
--------------------
"Out of the night that covers me,
Black as the Pit from pole to pole,
I thank whatever gods may be
For my unconquerable soul.
.....
It matters not how strait the gate,
How charged with punishments the scroll,
I am the master of my fate;
I am the captain of my soul." - "Invictus" (abbreviated), William Ernest Henley, 1875
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 21 2008, 03:29 AM
|
Junior Member
Group: Junior Member
Posts: 108
Joined: 28-May 08
From: India
Member No.: 25,593
|
QUOTE (moonlightress @ Aug 21 2008, 12:16 PM) I was only ever at 15mg and I was an eating-sleeping machine. I felt good, though! A user at another site has this to say about Mitz. CODE This stuff is nothing more than legal marijuana, and if I knew crap about biochemistry I could probably prove that crazy statement. From a purely molecular-chemical perspective THC and mirtazapine are nothing alike. But there's just something about how the two drugs work that is really close. And people who have self-medicated with pot respond really well to meds that really push the norepinephrine, and hard. Strattera, reboxetine, Cymbalta, and the more potent TCAs. And Remeron.
When it works it makes people feel really good. I mean really good. Remeron is the closest thing to a happy pill on the market. Until you get all bummed out about how much weight you've put on and how little you do because you're sleeping all the time. I found the comments interesting and I have to say I agree with them; even though they sound awful scary. What do others think about the comments -- agree/disagree? I wonder what Lambvet would have to say?
This post has been edited by Rahul: Aug 21 2008, 03:30 AM
--------------------
I'm not a doctor or a health professional and any advice in my post is purely my personal opinion.
Dx: MDD
Rx: 10 mg escitalopram + 15mg mitrazapine + 0.5mg clonazepam at bedtime
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 24 2008, 07:30 AM
|
Junior Member
Group: Junior Member
Posts: 108
Joined: 28-May 08
From: India
Member No.: 25,593
|
QUOTE (Mimen @ Aug 24 2008, 11:37 AM) I dont agree with the post. For me it works really well. The sleepiness stopped after about day 4 and the cravings took about 3 weeks to subside. I was hoping someone would disagree. I don't have sleepiness anymore and the hours I sleep are also gradually reducing. As far as the cravings are concerned, I think it's only my normal appetite. BTW what dosage are you on and for how long?
--------------------
I'm not a doctor or a health professional and any advice in my post is purely my personal opinion.
Dx: MDD
Rx: 10 mg escitalopram + 15mg mitrazapine + 0.5mg clonazepam at bedtime
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 Aug 25 2008, 01:02 PM
|
Junior Member
Group: Junior Member
Posts: 121
Joined: 18-February 08
From: South Africa
Member No.: 22,830
|
30 mg for about 3-4 months and loving it. Espescially for my anxiety. QUOTE (Rahul @ Aug 24 2008, 07:30 AM) QUOTE (Mimen @ Aug 24 2008, 11:37 AM) I dont agree with the post. For me it works really well. The sleepiness stopped after about day 4 and the cravings took about 3 weeks to subside. I was hoping someone would disagree. I don't have sleepiness anymore and the hours I sleep are also gradually reducing. As far as the cravings are concerned, I think it's only my normal appetite. BTW what dosage are you on and for how long? |
|
|
|
|
|
|
|
|
|
|
|
|
Aug 25 2008, 06:13 PM
|
Silver Member
Group: Silver Member
Posts: 957
Joined: 3-September 07
From: Wales
Member No.: 18,703
|
QUOTE (Rahul @ Aug 21 2008, 09:29 AM) QUOTE (moonlightress @ Aug 21 2008, 12:16 PM) I was only ever at 15mg and I was an eating-sleeping machine. I felt good, though! A user at another site has this to say about Mitz. CODE This stuff is nothing more than legal marijuana, and if I knew crap about biochemistry I could probably prove that crazy statement. From a purely molecular-chemical perspective THC and mirtazapine are nothing alike. But there's just something about how the two drugs work that is really close. And people who have self-medicated with pot respond really well to meds that really push the norepinephrine, and hard. Strattera, reboxetine, Cymbalta, and the more potent TCAs. And Remeron.
When it works it makes people feel really good. I mean really good. Remeron is the closest thing to a happy pill on the market. Until you get all bummed out about how much weight you've put on and how little you do because you're sleeping all the time. I found the comments interesting and I have to say I agree with them; even though they sound awful scary. What do others think about the comments -- agree/disagree? I wonder what Lambvet would have to say? Rahul, crazymeds.us ???
--------------------
"Every day when I wake up I thank the Lord I'm Welsh" - Catatonia
|
|
|
|
|
|
|
|
|
|
|
|
|
Aug 26 2008, 02:45 AM
Post
| |
If Serotonin Is The Problem/answer Is Remeron Serotonin Actions Be As Effective As A Ssri |
Add To Bookmarks
Depression Forums - A Depression & Mental Health Community Support Group > DEPRESSION & ANXIETY MEDICATIONS - LOOKING FOR ANSWERS > Remeron® - (Mirtazapine, Zispin)
·
·
·
·
·
·
·
·
·
·
·
·
