Late-life Anxiety Is Treatable with Cognitive Behavior Therapy;
Improves Mental Health

Older adults with generalized anxiety disorder who received
cognitive behavior therapy had greater improvement on measures of
worry, depression and mental health than patients who received usual
care, according to a study in the April 8 issue of
JAMA.
Generalized anxiety disorder (GAD) is common in late life, with
prevalence up to 7.3 percent in the community and 11.2 percent in
primary care. Late-life anxiety predicts increased physical disability,
memory difficulties and decreased quality of life, according to
background information in the article. Late-life anxiety is usually
treated with medication, but associated risks (e.g., falls, hip
fractures, memory problems) with some drugs and patient fears of
adverse effects limit their usefulness. Two previous studies suggested
benefits of cognitive behavior therapy (CBT) in primary care for
late-life GAD, but the studies were small and the conclusions were
limited. Older adults most often seek treatment for GAD in primary
care.
Melinda A. Stanley, Ph.D., of the Baylor College of Medicine, Houston,
and colleagues conducted the first randomized clinical trial of CBT for
late-life GAD in primary care to examine whether CBT would improve
outcomes relative to enhanced usual care (EUC). The trial included 134
older adults (average age, 67 years) in two primary care settings, with
treatment provided for 3 months. Assessments were conducted at the
beginning of the trial, posttreatment (3 months), and over 12 months of
follow-up, with assessments at 6, 9, 12 and 15 months. Patients were
randomized to either CBT (n = 70), which included education and
awareness, relaxation training, cognitive therapy, problem-solving
skills training and behavioral sleep management; or EUC (n = 64), in
which patients were telephoned biweekly during the first 3 months of
the study by the same therapists to provide support and ensure patient
safety. Therapists reminded patients to call project staff if symptoms
worsened.
Levels of anxiety, worry, depression and physical/mental health quality
of life were measured via various tests or surveys. The researchers
found that CBT, compared with EUC, significantly improved worry
severity, depressive symptoms and general mental health. In
intention-to-treat analyses, response rates defined according to worry
severity were higher following CBT compared with EUC at 3 months (40.0
percent vs. 21.9 percent).
"This study is the first to suggest that CBT can be useful for managing
worry and associated symptoms among older patients in primary care,"
the authors write. "This study paves the way for future research to
test sustainable models of care in more demographically heterogeneous
groups."
JAMA 2009;301[14]:1460-1467.